Increased adhesiveness of granulocytes in rabbit ear-chamber blood vessels perfused with neuraminidase

Görög, P.; Born, G. V. R.

doi:10.1016/s0026-2862(82)80010-1

Cited by 18 publications

(2 citation statements)

References 6 publications

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“…Furthermore, heparanase inhibitors have been demonstrated to prevent the endotoxemia associated loss of the glycocalyx on the vascular endothelium and neutrophil attachment (Schmidt et al, 2012). These effects of the heparanase inhibitors led to an attenuation of sepsis-induced acute lung injury and mortality in mice (Schmidt et al, 2012) and reinforce the important regulatory role played by the endothelial glycocalyx in leukocyte trafficking, first suggested many years earlier after the seminal experiments of Görög and Born (1982), whereby removal of sialic acid residues from the endothelial surface with neuraminidase led to massive leukocyte adhesion to the endothelium.…”

Section: Effects On Heparanase In Inflammationmentioning

confidence: 92%

Pharmacology of Heparin and Related Drugs

et al. 2015

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Section: Effects On Heparanase In Inflammationmentioning

confidence: 92%

Pharmacology of Heparin and Related Drugs

et al. 2015

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“…43 Born was also a pioneer in the use of intravital microscopy to explore the interaction of leukocytes with the vasculature in the microcirculation. [44][45][46][47][48] With his focus on neutrophils and their role in atherothrombosis, a today's 'hot topic', he was decades ahead of current research. Nowadays, Born's experiments are even more striking, when considering that, in the pre-digital era, the records had to be captured in pitch darkness on 16mm cine film.…”

Section: Platelet Imaging and Leukocyte Biologymentioning

confidence: 99%

The Prominent Pioneering ‘Plateleteer’: Reflections on and Personal Reminiscences of Gustav V. R. Born (1921–2018)

Scharf

2019

Hamostaseologie

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Among the pioneers in platelet research, Gustav Born was perhaps the most prominent representative, just a real “plateleteer”. He achieved scientific fame for the invention and application of light transmission aggregometry. Importantly, he paved the way for contemporary antiplatelet therapy. Integrating his fundamental knowledge of platelet biology into the pathology of vascular disorders, Born provided seminal contributions to the understanding of atherogenesis and thrombogenesis. He also generated visions for pharmacological strategies that, nowadays, are translated into reality. Inside and outside of science, Born was a great man. He had a deeply held belief in humanity. In this article, his life, scientific career and achievements are appreciated together with personal reminiscences of this outstanding personality.

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Platelet activating factor and inflammation in atherogenesis: Targets for drug development

Handley¹,

Saunders²

1986

Drug Development Research

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There is substantial evidence that the pathogenesis of atherosclerosis has one or more inflammatory components. As arterial injury is a primary event in the disease initiation and progression, inflammatory agents which injure and thus increase permeability of the arterial endothelium may lead to the development of atherosclerosis. The actions of circulatory mediators of inflammation to increase endothelial permeability may consequently accelerate entry or infiltration of lipid and other plasma macromolecules into the vessel wall. Reviewed are the biological properties of platelet activating factor (PAF), a potent lipid mediator believed to play a role in such disease states as allergic asthma, inflammation, systemic shock, myocardial ischemia, and allograph rejection. Emphasized are the actions of PAF related to increased endothelial permeability, cardiovascular actions and pathological profiles which indicate a role in the development of atherosclerosis and heart disease.

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Increased adhesiveness of granulocytes in rabbit ear-chamber blood vessels perfused with neuraminidase

Cited by 18 publications

References 6 publications

Pharmacology of Heparin and Related Drugs

Pharmacology of Heparin and Related Drugs

The Prominent Pioneering ‘Plateleteer’: Reflections on and Personal Reminiscences of Gustav V. R. Born (1921–2018)

Platelet activating factor and inflammation in atherogenesis: Targets for drug development

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