2015
DOI: 10.1038/pr.2015.90
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Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure

Abstract: Background Continuous positive airway pressure (CPAP) is a primary form of respiratory support used in the intensive care of preterm infants, but its long-term effects on airway (AW) function are unknown. Methods We developed a neonatal mouse model of CPAP treatment to determine whether it modifies later AW reactivity. Un-anesthetized spontaneously breathing mice were fitted with a mask to deliver CPAP (6cmH2O, 3hrs/day) for 7 consecutive days starting at postnatal day 1. Airway reactivity to methacholine wa… Show more

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Cited by 21 publications
(22 citation statements)
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“…We have previously documented an increase in airway reactivity in an in vitro lung slice model after neonatal mice were exposed to CPAP under normoxic conditions [16]. Unlike our current in vivo study, the lung slices did not allow measurement of baseline respiratory mechanics.…”
Section: Discussionmentioning
confidence: 86%
See 2 more Smart Citations
“…We have previously documented an increase in airway reactivity in an in vitro lung slice model after neonatal mice were exposed to CPAP under normoxic conditions [16]. Unlike our current in vivo study, the lung slices did not allow measurement of baseline respiratory mechanics.…”
Section: Discussionmentioning
confidence: 86%
“…Therefore, there is a need for an animal model of BPD that simulates current clinical practice in the human preterm infant. We have previously reported the ability to successfully administer CPAP to a neonatal mouse [16]. This is the first report of in vivo respiratory function data following CPAP administration to a small rodent and the model has the ability for longer-term follow-up experiments of respiratory function.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Table 1). The majority randomized animals to intervention groups [3,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and reported temperature control [3,[17][18][19][20][21][22][27][28][29][30][31][32][33][34]. Weaknesses include few studies which blinded all outcome measures [3,16,24], or avoided anesthesia with intrinsic…”
Section: Quality Appraisalmentioning
confidence: 99%
“…Rabbit and mouse Unventilated: Mayer et al [20] Hyperoxia-induced lung injury: Reyburn et al [21], Gie et al [22] Lung structure No disruption of alveolar development [21,22], reduced radial alveolar count [20] Limited hyperoxia-induced respiratory epithelial thickening and muscularization of pulmonary arteries [22] Gas exchange None…”
Section: Small Animalmentioning
confidence: 99%