Increased antibiotic use in Norwegian hospitals despite a low antibiotic resistance rate

Haug, Jon Birger; Berild, Dag; Walberg, Mette; Reikvam, Åsmund

doi:10.1093/jac/dkr361

Cited by 22 publications

(19 citation statements)

References 7 publications

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“…The significant increase in carbapenem and third‐generation cephalosporin consumption shown in the present study was consistent with reports from Norway, Denmark, Sweden and the Netherlands . The increased consumption of imidazole derivatives was in line with national data from Denmark, whereas a decrease has been observed in Sweden.…”

Section: Discussionsupporting

confidence: 92%

A worrying trend in weight‐adjusted paediatric antibiotic use in a Norwegian tertiary care hospital

et al. 2015

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Section: Discussionsupporting

confidence: 92%

A worrying trend in weight‐adjusted paediatric antibiotic use in a Norwegian tertiary care hospital

et al. 2015

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“…If atypical bacteria are suspected, addition of a macrolide should be considered . However, newly published data indicate an increase in the use of broad‐spectrum antibiotics in hospitals in Norway . The resistance pattern and absence of MRSA cases, combined with the low frequency of atypical agents in our study indicate that, in the case of uncomplicated CAP, the Norwegian guidelines are appropriate to the bacterial aetiology presented here.…”

Section: Discussionmentioning

confidence: 50%

Aetiology and risk factors of community‐acquired pneumonia in hospitalized patients in Norway

Røysted

Simonsen

Jenkins

et al. 2015

Clinical Respiratory J

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“…However, a considerable gap exists between theory and clinical practice [7]. Antibiotic use is increasing even in some countries such as Norwegian with a low antibiotic resistance rate [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Antimicrobial stewardship of Chinese ministry of health reduces multidrug-resistant organism isolates in critically ill patients: a pre-post study from a single center

Xie

Yang

et al. 2016

BMC Infect Dis

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BackgroundChina’s Ministry of Health (MOH) has established a policy about the antimicrobial stewardship. To date, the effects of this policy on multidrug-resistant organism (MDRO) in critically ill patients are unknown.MethodsA pre-post study was conducted on intensive care unit (ICU) patients from June 2010 to May 2011 and from June 2012 to May 2013. Bacterial cultures were conducted at ICU admission and discharge. In June 2011, our hospital started to administer the antimicrobial stewardship program of Chinese MOH. We collected the data on antimicrobial consumption during the 3-year period in all hospital and individual department every month, and analyzed the correlation between the proportion of critically patients colonized or infected with MDRO and antimicrobial consumption.ResultsA total of 978 patients were involved in the present study. With the intervention, the monthly mean Defined Daily Dose (DDD) per 100 occupied bed-days throughout the hospital decreased from 96 ± 7 to 65 ± 6 (p < 0.001), and the proportion of patients colonized or infected with MDRO decreased from 36 to 13% at the time of ICU admission and declined from 48 to 29% at the time of ICU discharge (both p < 0.001). There was a significant positive relationship between the proportion of all critically ill patients colonized or infected with MDRO at ICU admission and the DDD of the entire hospital (R2 = 0.7858, p < 0.001).ConclusionThe antimicrobial stewardship program of Chinese MOH reduced the consumption of antibiotics. Moreover, the proportion of patients colonized or infected with MDRO decreased along with reduced consumption of antibiotics.Trial registrationRetrospectively registered: NCT02128399; Date of registration: 22 APR 2014; Detail information web link: https://clinicaltrials.gov/ct2/show/NCT02128399?term=NCT02128399&rank=1 Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2051-8) contains supplementary material, which is available to authorized users.

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Increased antibiotic use in Norwegian hospitals despite a low antibiotic resistance rate

Abstract: There was a substantial increase in total antibiotic use, and an even more pronounced increase in the use of broad-spectrum antibiotics, which seems unjustified considering the current low antibiotic resistance in Norway.

Cited by 22 publications

References 7 publications

A worrying trend in weight‐adjusted paediatric antibiotic use in a Norwegian tertiary care hospital

A worrying trend in weight‐adjusted paediatric antibiotic use in a Norwegian tertiary care hospital

Aetiology and risk factors of community‐acquired pneumonia in hospitalized patients in Norway

Antimicrobial stewardship of Chinese ministry of health reduces multidrug-resistant organism isolates in critically ill patients: a pre-post study from a single center

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