Increased antibodies for the α7 subunit of the nicotinic receptor in schizophrenia

Chandley, Michelle J.; Miller, Merry N.; Kwasigroch, Christine Newell; Wilson, Tracy D.; Miller, Barney E.

doi:10.1016/j.schres.2009.01.023

Cited by 39 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, patients with schizophrenia have elevated levels of autoantibodies against many neurotransmitter receptors (i.e. nAChRs) (Margutti et al, 2006;Chandley et al, 2009). Post-mortem autoradiographic studies have revealed disturbances in the expression levels of a7 and a4b2 nAChRs in various cerebral areas of patients with schizophrenia.…”

Section: Alterations Of the Cholinergic System In Schizophreniamentioning

confidence: 99%

Smoking, nicotine and neuropsychiatric disorders

Döme

Lazáry

Kalapos³

et al. 2010

Neuroscience & Biobehavioral Reviews

199

140

View full text Add to dashboard Cite

Section: Alterations Of the Cholinergic System In Schizophreniamentioning

confidence: 99%

Smoking, nicotine and neuropsychiatric disorders

Döme

Lazáry

Kalapos³

et al. 2010

Neuroscience & Biobehavioral Reviews

199

140

View full text Add to dashboard Cite

“…Examples of this pattern include: RHD and GYPA, autoantigens in autoimmune hemolytic anemia; AMY2A, an autoantigen in autoimmune pancreatitis and fulminant T1D, and a binding partner of the CD autoantigen GP2 [118]; CES1 and PDIA3, autoantigens in type-2 autoimmune hepatitis; TYR, an autoantigen in vitiligo; and CHRNA7, an autoantigen observed in schizophrenia (Tables 1 and 2, [154]). The genomic structure of TYR makes it particularly susceptible to gene conversion and deletion (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Coherent Somatic Mutation in Autoimmune Disease

Ross

2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundMany aspects of autoimmune disease are not well understood, including the specificities of autoimmune targets, and patterns of co-morbidity and cross-heritability across diseases. Prior work has provided evidence that somatic mutation caused by gene conversion and deletion at segmentally duplicated loci is relevant to several diseases. Simple tandem repeat (STR) sequence is highly mutable, both somatically and in the germ-line, and somatic STR mutations are observed under inflammation.ResultsProtein-coding genes spanning STRs having markers of mutability, including germ-line variability, high total length, repeat count and/or repeat similarity, are evaluated in the context of autoimmunity. For the initiation of autoimmune disease, antigens whose autoantibodies are the first observed in a disease, termed primary autoantigens, are informative. Three primary autoantigens, thyroid peroxidase (TPO), phogrin (PTPRN2) and filaggrin (FLG), include STRs that are among the eleven longest STRs spanned by protein-coding genes. This association of primary autoantigens with long STR sequence is highly significant (). Long STRs occur within twenty genes that are associated with sixteen common autoimmune diseases and atherosclerosis. The repeat within the TTC34 gene is an outlier in terms of length and a link with systemic lupus erythematosus is proposed.ConclusionsThe results support the hypothesis that many autoimmune diseases are triggered by immune responses to proteins whose DNA sequence mutates somatically in a coherent, consistent fashion. Other autoimmune diseases may be caused by coherent somatic mutations in immune cells. The coherent somatic mutation hypothesis has the potential to be a comprehensive explanation for the initiation of many autoimmune diseases.

show abstract

“…Similarly, autoantibodies against the α7 adult subunit of the nicotinic AChR (nAChR) were found in five out of 21 (23%) schizophrenia patients [149].…”

Section: Psychotic Disordersmentioning

confidence: 99%

“…Presumably, a number of antigens involved in neuropsychiatric disorders are still not well understood demanding further work to identify novel autoantibody targets and help to better diagnose autoimmune patients' subgroups and understand disease mechanisms. n/a n/a HTR-1A + [148] n/a n/a n/a mAChR + [147,148] + [147,164] n/a n/a nAChR + [149] n/a n/a n/a GAD +/´ [144,154]´ [99] n/a + [154] FR + [202,212] n/a n/a n/a…”

Section: Conclusion/future Directionsmentioning

confidence: 99%

Autoantibodies in Neuropsychiatric Disorders

et al. 2016

View full text Add to dashboard Cite

Abstract:Little is known about the etiology of neuropsychiatric disorders. The identification of autoantibodies targeting the N-methyl-D-aspartate receptor (NMDA-R), which causes neurological and psychiatric symptoms, has reinvigorated the hypothesis that other patient subgroups may also suffer from an underlying autoimmune condition. In recent years, a wide range of neuropsychiatric diseases and autoantibodies targeting ion-channels or neuronal receptors including NMDA-R, voltage gated potassium channel complex (VGKC complex), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R), γ-aminobutyric acid receptor (GABA-R) and dopamine receptor (DR) were studied and conflicting reports have been published regarding the seroprevalence of these autoantibodies. A clear causative role of autoantibodies on psychiatric symptoms has as yet only been shown for the NMDA-R. Several other autoantibodies have been related to the presence of certain symptoms and antibody effector mechanisms have been proposed. However, extensive clinical studies with large multicenter efforts to standardize diagnostic procedures for autoimmune etiology and animal studies are needed to confirm the pathogenicity of these autoantibodies. In this review, we discuss the current knowledge of neuronal autoantibodies in the major neuropsychiatric disorders: psychotic, major depression, autism spectrum, obsessive-compulsive and attention-deficit/hyperactivity disorders.

show abstract

Increased antibodies for the α7 subunit of the nicotinic receptor in schizophrenia

Cited by 39 publications

References 19 publications

Smoking, nicotine and neuropsychiatric disorders

Smoking, nicotine and neuropsychiatric disorders

Coherent Somatic Mutation in Autoimmune Disease

Autoantibodies in Neuropsychiatric Disorders

Contact Info

Product

Resources

About