Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation

Abstract

Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis.

Serum biomarkers for diagnosis and assessment of severity in psoriasis

“…The findings of present study correlate well with findings of previous studies -Pereira et al (2004) [5], Coimbra et al (2009) [15], Yiu et al (2011) [16] and Lucy Piper et al (2012) [4].…”

Biochemical markers of psoriasis as a metabolic disease

“…It has been suggested that the inflammatory process in psoriasis, which is characterized by elevated levels of CRP, is connected to increased arterial stiffness and premature development of atherosclerosis. These findings provide further evidence of a link between inflammation and cardiovascular diseases in patients with psoriasis [220]. This study is consistent with the research published by Ludwig et al [221], which reported an increased prevalence and severity of coronary artery calcification as an indicator for cardiovascular disease in patients with psoriasis.…”

“…Considering these results, the authors suggested that in psoriasis there might be an inflammatory process which persists even after the therapy, and may lead to the development of atherogenic changes [219]. A positive correlation between elevated serum levels of high sensitivity of CRP (hs-CRP) and the degree of arterial stiffness in patients with psoriasis was reported in another study [220]. Moreover, increased concentration of hs-CRP seems to be an independent predictor of arterial stiffness.…”

Psoríase e Doença Cardiovascular: Impacto da Terapêutica com Inibidores do TNF-alfa

“…23,24 Uma das técnicas utilizadas para a sua avaliação é a medição da velocidade da onda de pulso (VOP) arterial, definida pela distância percorrida pelo fluxo sanguíneo dividida pelo tempo que esta leva a percorrer essa distância (m/s). 23 Yiu et al 25 verificaram que a VOP braquial-tornozelo (VOP b-t ) nos doentes com psoríase estava significativamente aumentada quando comparada com a dos indivíduos saudáveis do mesmo sexo e idade. Para além disso mostraram que, nos doentes psoriáticos, existia uma correlação positiva entre a VOP b-t e a idade.…”