Increased ASF1B Expression Correlates With Poor Prognosis in Patients With Gliomas

Zhu, Huaxin; Ouyang, Hengyang; Pan, Xinyi; Zhang, Zhixiong; Tan, Jiacong; Yu, Nianzu; Li, Meihua; Zhao, Yue

doi:10.3389/fonc.2022.912101

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…Moreover, ASF1A and ASF1B interact with other histone chaperone proteins, fostering the chromatin regulation processes [ 38 ]. Over-expression or depletion of the ASF1A and ASF1B proteins is reported to be associated with carcinogenesis and tumorigenesis through interaction with other histone chaperone proteins [ 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity

Lee,

Bao

2024

IJMS

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Histone chaperones are integral to chromatin dynamics, facilitating the assembly and disassembly of nucleosomes, thereby playing a crucial role in regulating gene expression and maintaining genomic stability. Moreover, they prevent aberrant histone interactions prior to chromatin assembly. Disruption in histone chaperone function may result in genomic instability, which is implicated in pathogenesis. This review aims to elucidate the role of histone chaperones in cancer pathologies and explore their potential as therapeutic targets. Histone chaperones have been found to be dysregulated in various cancers, with alterations in expression levels, mutations, or aberrant interactions leading to tumorigenesis and cancer progression. In addition, this review intends to highlight the molecular mechanisms of interactions between histone chaperones and oncogenic factors, underscoring their roles in cancer cell survival and proliferation. The dysregulation of histone chaperones is significantly correlated with cancer development, establishing them as active contributors to cancer pathology and viable targets for therapeutic intervention. This review advocates for continued research into histone chaperone-targeted therapies, which hold potential for precision medicine in oncology. Future advancements in understanding chaperone functions and interactions are anticipated to lead to novel cancer treatments, enhancing patient care and outcomes.

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Section: Resultsmentioning

confidence: 99%

Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity

Lee,

Bao

2024

IJMS

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Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats

Tello‐Palencia,

Yang,

Sularz

et al. 2024

Molecular Nutrition Food Res

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ScopePolyphenols from the phytoestrogen group, including pterostilbene (PTS), are known for their antioxidant, anti‐inflammatory, and anti‐cancer effects. In recent reports, phytoestrogens attenuate age‐related diseases; however, their pro‐longevity effects in healthy models in mammals remain unknown. As longevity research demonstrates age‐related transcriptomic signatures in human blood, the current study hypothesizes that phytoestrogen‐supplemented diet may induce changes in gene expression that ultimately confer pro‐longevity benefits.Methods and resultsIn the present study, RNA sequencing is conducted to determine transcriptome‐wide changes in gene expression in whole blood of healthy rats consuming diets supplemented with phytoestrogens. Ortholog cell deconvolution is applied to analyze the omics data. The study discovered that PTS leads to changes in the gene expression landscape and PTS‐target genes are associated with functions counteracting hallmarks of aging, including genomic instability, epigenetic alterations, compromised autophagy, mitochondrial dysfunction, deregulated nutrient sensing, altered intercellular interaction, and loss of proteostasis. These functions bridge together under anti‐inflammatory effects through multiple pathways, including immunometabolism, where changes in cellular metabolism (e.g., ribosome biogenesis) impact the immune system.ConclusionThe findings provide a rationale for pre‐clinical and clinical longevity studies and encourage investigations on PTS in maintaining cellular homeostasis, decelerating the process of aging, and improving conditions with chronic inflammation.

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The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma

Zhang

Liu

2023

Annals of Medicine

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Aim Low-grade glioma (LGG), which is the second most frequent adult brain malignancy, severely threatens patients’ health and has a high recurrence rate. Histone H3/H4 chaperone anti-silencing function 1 B ( ASF1B ) has a tight association with the initiation and development of tumours. The expression and regulation mechanism of ASF1B in LGG were discussed. Methods ASF1B expression in LGG patients as well as the association of ASF1B with overall survival and disease-free survival of LGG patients were predicted by GEPIA database. The independent prognostic value of ASF1B in LGG patients was investigated by TCGA database. RT-qPCR, together with western blot was applied for the assessment of ASF1B in LGG cell lines. After ASF1B expression was inhibited, CCK8 and colony formation assays judged cell proliferation. Flow cytometry analysis and TUNEL assay appraised cell cycle as well as apoptosis. Cell migratory and invasive capacities were measured by wound healing as well as Transwell assays. Western blot tested the expression of proliferation-, cycle-, apoptosis-, and metastasis-associated proteins. STRING and GeneMANIA database predicted the relationship between ASF1B and tousled-like kinase 1 ( TLK1) . ChIP assay testified the affinity of ASF1B with TLK1. Subsequently, TLK1 was overexpressed and ASF1B expression interfered, and the functional assays were executed. Results ASF1B was discovered to be increased in LGG tissues and cells and indicates an unfavourable prognosis for LGG patients. ASF1B was not an independent prognostic factor for LGG. ASF1B deficiency obstructed the proliferation, cell cycle as well as metastasis of LGG cells, and induced cell death, which might be realized through the interaction with TLK1 . Conclusion The interaction between ASF1B and TLK1 promoted the malignant progression of LGG. Key messages TLK1 interacts with ASF1B. Interference with ASF1B inhibits the proliferative, invasive and migratory capabilities and induces the cycle arrest, along with the apoptosis of LGG cells. The interaction between ASF1B and TLK1 promotes the malignant progression of LGG.

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Increased ASF1B Expression Correlates With Poor Prognosis in Patients With Gliomas

Cited by 4 publications

References 42 publications

Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity

Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity

Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats

The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma

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