Increased association of ovarian cancer in women with histological proven endosalpingiosis

Hermens, Marjolein; Altena, Anne M. van; Bulten, Johan; Siebers, Albert G.; Bekkers, Ruud L.M.

doi:10.1016/j.canep.2020.101700

Cited by 16 publications

(16 citation statements)

References 23 publications

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“…Recent studies have reported a prevalence of ES at 1.5%[1] -3.5% [20], and a significant association with gynecologic cancers, particularly after menopause [1], raising the question whether ES could be a malignant precursor lesion. Another nationwide registry cohort study subsequently also reported an association of ES with ovarian cancer [21]. We also found ES (9/ 19), as well as OIC (10/19) present in menopausal patients with cancer approximately 50% of the time.…”

Section: Discussionsupporting

confidence: 76%

Prevalence of endosalpingiosis and other benign gynecologic lesions

et al. 2020

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Endosalpingiosis, traditionally regarded as an incidental pathological finding, was recently reported to have an association with gynecologic malignancies. To determine the prevalence of endosalpingiosis, we evaluated all benign appearing adnexal lesions using the Sectioning and Extensively Examining-Fimbria (SEE-Fim) protocol, and queried the pathology database for the presence of endosalpingiosis, gynecologic malignancy, endometriosis, Walthard nests, and paratubal cysts. Using the SEE-Fim protocol, the prevalence of endosalpingiosis, endometriosis, Walthard nests, and paratubal cysts were 22%, 45%, 33%, and 42% respectively, substantially higher than previously reported. All lesions were observed to increase with age except endometriosis which increased until menopause then decreased dramatically. Among specimens including ovarian tissue, the prevalence of implantation of at least one lesion type was ubiquitous in patients age 51 and older (93%). The clinical significance of endosalpingiosis should be a continued area of research with larger trials assessing prevalence, factors affecting incidence, and association with malignancy. Our findings contribute to elucidating the origin of ectopic lesions and gynecologic disease risk.

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Section: Discussionsupporting

confidence: 76%

Prevalence of endosalpingiosis and other benign gynecologic lesions

et al. 2020

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“…It is most commonly discovered as an incidental finding upon histopathological examination of tissue from gastrointestinal or gynecologic surgery. Occasionally gross changes can be identified intra-operatively as multiple, punctate fluid-filled small cysts [ 7 ]. Reported prevalence of endosalpingiosis within the literature varies from 1 to 22% [ 6 , 8 , 10 ] from pathological analyses of varying populations of patients undergoing gynecologic surgery.…”

Section: Discussionmentioning

confidence: 99%

Appendiceal endosalpingiosis: a case report of a rare finding from appendicectomy

Nayak

Karpes

Stewart

2022

Journal of Surgical Case Reports

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Endosalpingiosis is occasionally incidentally found on histopathologic examination of gynecologic or gastrointestinal specimen, most commonly in the ovary, fallopian tube, omentum and uterus. Recently an association between endosalpingiosis and, ovarian and uterine cancer has been described. Here, we describe a rare case of appendiceal endosalpingiosis mimicking appendicitis. Further prospective studies are required to elucidate the clinical significance of appendiceal endosalpingiosis, the potential association with gynecologic malignancy and implications for management.

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“…This second theory explains the presence of ES in women only and that the most common localization of ES is in the ovaries. Relevant clinical data about ES are scarce, although recent studies show its association with gynaecological malignancies [13]. A significant relationship between ES and borderline ovarian carcinoma (BOC) has been observed.…”

Section: Endosalpingiosismentioning

confidence: 99%

Ovarian Cancer Tumour Biology: Genesis

Varga¹

2021

Ovarian Cancer - Updates in Tumour Biology and Therapeutics [Working Title]

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Ovarian cancer (OC) is the fifth leading cause of cancer deaths among women, thus early diagnosis is of paramount importance to survival. A clear OC etiopathogenesis is not yet fully understood. Large histopathological variability predicts more initial tissue for carcinogenesis. Many connections of biologically different tissue as locus minoris resistentiae for carcinogenesis have been confirmed. Expansion of knowledge about OC etiopathogenesis may help to construct an algorithm for early diagnosis. Ovarian surface epithelium, ectopic Müllerian epithelium, and fallopian tubes, along with endometriosis, are significant in the process of OC development. An oxidative microenvironment caused by recurrent ovulation or arising due to a degradative process in ectopic endometrium, mainly endometriomas, play a prominent role in the development of OC.

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Increased association of ovarian cancer in women with histological proven endosalpingiosis

Cited by 16 publications

References 23 publications

Prevalence of endosalpingiosis and other benign gynecologic lesions

Prevalence of endosalpingiosis and other benign gynecologic lesions

Appendiceal endosalpingiosis: a case report of a rare finding from appendicectomy

Ovarian Cancer Tumour Biology: Genesis

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