Increased blood-brain barrier permeability of neuroprotective drug by colloidal serum albumin carriers

Hornok, Viktória; Amin, Keristina Wagdi K.; Kovács, Alexandra N.; Juhász, Ádám; Katona, Gábor; Balogh, György Tibor; Csapó, Edit

doi:10.1016/j.colsurfb.2022.112935

Cited by 9 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies have emphasized the function of the blood–brain barrier (BBB) in safeguarding the brain from exogenous, neurotoxic, and other substances in the blood, thereby impeding the passage of nearly 98% of small-molecule drugs. Therefore, the ability to traverse the BBB and target particular regions of the brain tissue is an essential property of chemicals or molecules that exhibit neuroprotective effects ( Hornok et al, 2022 ; Katila et al, 2022 ). As previously stated, there is compelling evidence that all the aforementioned predicted Q-markers described could cross the BBB and provide varying degrees of neuroprotection ( Li, 2007 ; Zhang et al, 2011 ; Wang et al, 2013 ; Zhu et al, 2013 ; Yang, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS/MS

Wu,

Ou,

Wang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Background: The Jiawei Kongsheng Zhenzhong pill (JKZP), a Chinese herbal prescription comprised of eight Chinese crude drugs, has been historically employed to treat neurological and psychological disorders. Nevertheless, the ambiguous material basis severely hindered its progress and application.Purpose: The current study aimed to establish a rapid analytical method for identifying the chemical components of the JKZP aqueous extract and the components absorbed into the rat serum to investigate the quality markers (Q-markers) responsible for the neuroprotective effects of JKZP.Methods: The qualitative detection of the chemical components, prototype components, and metabolites of the aqueous extracts of JKZP, as well as the serum samples of rats that were administered the drug, was performed using the ultra-performance liquid chromatography- quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) technology. This analysis combined information from literature reports and database comparisons. Moreover, the study was conducted to anticipate the potential Q-markers for the neuroprotective effects of JKZP based on the “five principles” of Q-marker determination.Results: A total of 67 compounds and 111 serum components (comprising 33 prototypes and 78 metabolites) were detected and identified. Combining the principles of quality transmission and traceability, compound compatibility environment, component specificity, effectiveness, and measurability, the study predicted that five key compounds, namely, senkyunolide H, danshensu, echinacoside, loganin, and 3,6′-disinapoyl sucrose, may serve as potential pharmacological bases for the neuroprotective effects of JKZP.Conclusion: To summarize, the UPLC-Q-TOF-MS/MS technique can be employed to rapidly and accurately identify compounds in JKZP. Five active compounds have been predicted to be the Q-markers for the neuroprotective effects of JKZP. This discovery serves as a reference for improving quality, advancing further research and development, and utilizing Chinese herbal prescriptions.

show abstract

Section: Discussionmentioning

confidence: 99%

Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS/MS

Wu,

Ou,

Wang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Albumin nanoparticles, known for their accessibility, effective drug binding, and stability against denaturation, serve as a notable drug carrier . With the aid of transport proteins on the BBB, they facilitate brain delivery, making them a potential strategy for targeting glioma stem cells . Therefore, Lu et al used a combination treatment with albumin nanoparticles delivering the antitumor drug paclitaxel (PTX) and the autophagy inhibitor CQ, and modified it with folic acid to enhance BBB penetration and cellular uptake .…”

Section: Nanodelivery Systems For Sniping Cscsmentioning

confidence: 99%

“…389 With the aid of transport proteins on the BBB, they facilitate brain delivery, making them a potential strategy for targeting glioma stem cells. 390 Therefore, Lu et al used a combination treatment with albumin nanoparticles delivering the antitumor drug paclitaxel (PTX) and the autophagy inhibitor CQ, and modified it with folic acid to enhance BBB penetration and cellular uptake. 391 The results showed increased sensitivity of PTX treatment to glioma stem cells and improved therapeutic efficacy in glioma.…”

Section: Liposome-based Nanomaterials For Targetingmentioning

confidence: 99%

Sniping Cancer Stem Cells with Nanomaterials

Wang,

Guo,

Yang

et al. 2023

ACS Nano

View full text Add to dashboard Cite

“…Albumin is synthesized by liver parenchymal cells, and its half-life in plasma is about 15–19 days. Albumin is the most abundant protein in plasma, accounting for 40%−60% of the total plasma proteins ( 10 ). Although albumin synthesis rate is affected by dietary protein intake, it is mainly regulated by the plasma protein level.…”

Section: Introductionmentioning

confidence: 99%

“…Prealbumin, also known as transthyretin, has a half-life in plasma of 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status (9). Albumin is synthesized by liver parenchymal cells, and its half-life in plasma is about 15-19 days.…”

Section: Introductionmentioning

confidence: 99%

Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study

Wang,

Xin,

Tang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundPostoperative delirium (POD) is a common postoperative neurological complication that can lead to a variety of postoperative complications. At present, the pathogenesis of POD is unclear. This study aims to explore the relationship between serum prealbumin and serum albumin and POD and whether serum prealbumin and serum albumin influence POD through POD core pathology.ObjectiveWe enrolled 500 Chinese Han patients between September 2020 to January 2023. We analyzed the risk and protective factors of POD using the multivariate logistic regression. We also assessed the predictive power of serum prealbumin, serum albumin, and both in combination with CSF POD biomarkers. We used Stata MP16.0. to examine whether the association between serum prealbumin and serum albumin and POD was mediated by CSF POD biomarkers, and conducted an internal validation study to verify the accuracy of the combination of serum prealbumin + serum albumin + CSF POD biomarkers for predicting POD. The model was visualized using ROC curve and decision curve analysis (DCA). DynNom and Shiny packages were used to create an online calculator. Ten patients who had POD occurring from February 2023 to October 2023 were selected for internal verification.ResultsFinally, a total of 364 patients were included in our study. Levels of serum prealbumin, serum albumin in the POD group were lower than those in the NPOD group. The lever of serum prealbumin, serum albumin were protective factors for POD. The relationship between serum prealbumin, serum albumin and POD was partially mediated by T-tau (12.28%) and P-tau (20.61%). The model combining serum prealbumin and serum albumin and POD biomarkers exhibited a relatively better discriminatory ability to predict POD. DCA also showed that the combination of serum prealbumin and serum albumin and POD biomarkers brought high predictive benefits to patients. The dynamic online calculator can accurately predict the occurrence of POD in the internal validation study.ConclusionPreoperative low serum prealbumin and serum albumin levels were the preoperative risk factors for POD, which is partly mediated by T-tau and P-tau. The model combining serum prealbumin and serum albumin and CSF POD biomarkers can accurately predict the occurrence of POD.Clinical trial registrationhttp://www.clinicaltrials.gov, identifier ChiCTR2000033439.

show abstract

Increased blood-brain barrier permeability of neuroprotective drug by colloidal serum albumin carriers

Cited by 9 publications

References 24 publications

Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS/MS

Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS/MS

Sniping Cancer Stem Cells with Nanomaterials

Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study

Contact Info

Product

Resources

About