Increased brain glucose metabolism in chronic severe traumatic brain injury as determined by longitudinal 18F-FDG PET/CT

Yamaki, Tomohiro; Uchino, Yuichi; Henmi, Haruko; Kamezawa, Mizuho; Hayakawa, Miyoko; Uchida, Tomoki; Ozaki, Yoshihiro; Onodera, Shinji; Oka, Naoki; Odaki, Masaru; Itou, Daisuke; Kobayashi, Shigeki

doi:10.1016/j.jocn.2018.08.052

Cited by 13 publications

(8 citation statements)

References 18 publications

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“…Decreased CBF may result from a lower metabolic demand from injured tissue, resulting in an appropriately matched reduction in blood flow. However, studies using fluorodeoxyglucose positron emission tomography (FDG-PET) have suggested that glucose metabolism is disrupted following TBI but can be increased, decreased, or unchanged in ways that do not clearly correlate with structural abnormalities (Ito et al, 2016;Yamaki et al, 2018).…”

Section: Evidence From Human Patientsmentioning

confidence: 99%

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Sandsmark

Bashir

Wellington

et al. 2019

Neuron

121

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Section: Evidence From Human Patientsmentioning

confidence: 99%

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Sandsmark

Bashir

Wellington

et al. 2019

Neuron

121

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“…As reported in Table 1 , other studies developed new behavioral tools to more specifically assess language abilities in post-comatose patients. For example, Yamaki et al 21 included an estimation of residual language based on the patient's bedside observation in their “Chiba score.” This scale comprises 11 items: level of wakefulness, motor activity, language comprehension (from no evidence to ability to understand language adequately for use in normal daily life), language expression (from no evidence to ability to communicate using sentences in normal daily life), visual cognition (from no eye movement following a moving object to evidence that the patient can communicate using visual information), auditory cognition (from no blink in response to a loud sound to evidence of verbal comprehension such as following verbal commands), nutrition, facial expression of emotion, excretion, position change, and movement. Another tool is the Cognitive Assessment by Visual Election (CAVE), 22 23 which is composed of six subscales evaluating recognition of objects, pictures, numbers, letters, written words, and colors.…”

Section: Language Assessment Tools In Post-comatose Patientsmentioning

confidence: 99%

Language Assessment in Patients with Disorders of Consciousness

2022

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The assessment of residual language abilities in patients with disorders of consciousness (DoC) after severe brain injury is particularly challenging due to their limited behavioral repertoire. Moreover, associated language impairment such as receptive aphasia may lead to an underestimation of actual consciousness levels. In this review, we examine past research on the assessment of residual language processing in DoC patients, and we discuss currently available tools for identifying language-specific abilities and their prognostic value. We first highlight the need for validated and sensitive bedside behavioral assessment tools for residual language abilities in DoC patients. As regards neuroimaging and electrophysiological methods, the tasks involving higher level linguistic commands appear to be the most informative about level of consciousness and have the best prognostic value. Neuroimaging methods should be combined with the most appropriate behavioral tools in multimodal assessment protocols to assess receptive language abilities in DoC patients in the most complete and sensitive manner.

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“…Notably, the PET data showed that CMRglc in VS/UWS, a severe type of disorders of consciousness (DOC), was reduced to 40–50% (Laureys et al, 2004 ). In patients with chronic severe TBI, those with a higher glucose uptake are associated with a higher level of wakefulness and better neurological outcomes (Yamaki et al, 2018 ). Furthermore, energy consumption levels in VS/UWS extract no more than 34% of the normal average; in contrast, the minimal conscious state (MCS), a less severe type of DOC extracts close to 50% of the normal average (Garcia-Panach et al, 2011 ).…”

Section: Brain Metabolism and Loss Of Consciousnessmentioning

confidence: 99%

How Energy Supports Our Brain to Yield Consciousness: Insights From Neuroimaging Based on the Neuroenergetics Hypothesis

Chen

Zhang

2021

Front. Syst. Neurosci.

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Consciousness is considered a result of specific neuronal processes and mechanisms in the brain. Various suggested neuronal mechanisms, including the information integration theory (IIT), global neuronal workspace theory (GNWS), and neuronal construction of time and space as in the context of the temporospatial theory of consciousness (TTC), have been laid forth. However, despite their focus on different neuronal mechanisms, these theories neglect the energetic-metabolic basis of the neuronal mechanisms that are supposed to yield consciousness. Based on the findings of physiology-induced (sleep), pharmacology-induced (general anesthesia), and pathology-induced [vegetative state/unresponsive wakeful syndrome (VS/UWS)] loss of consciousness in both human subjects and animals, we, in this study, suggest that the energetic-metabolic processes focusing on ATP, glucose, and γ-aminobutyrate/glutamate are indispensable for functional connectivity (FC) of normal brain networks that renders consciousness possible. Therefore, we describe the energetic-metabolic predispositions of consciousness (EPC) that complement the current theories focused on the neural correlates of consciousness (NCC).

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Increased brain glucose metabolism in chronic severe traumatic brain injury as determined by longitudinal 18F-FDG PET/CT

Cited by 13 publications

References 18 publications

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Language Assessment in Patients with Disorders of Consciousness

How Energy Supports Our Brain to Yield Consciousness: Insights From Neuroimaging Based on the Neuroenergetics Hypothesis

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