Increased C-Reactive Protein in Young Adult Patients with Migraine

Abstract

Interictal serum C-reactive protein (CRP) was measured in 50 young adult patients with migraine and compared with 50 controls. The median CRP level was 1.42 mg/l in patients with migraine and 0.90 mg/l in controls (P = 0.03). This finding supports the role of inflammation in migraine, but needs confirmation in larger controlled studies. Prospective studies may establish whether measurements of CRP can identify patients with migraine at risk for cardiovascular events.

Cardiovascular Disease Risk Profile in Japanese Midlife Migraineurs

“…In contrast, previous Belgian study addressed that BP and serum levels of TC and LDL-C did not differ in young migraineurs (n = 50) and controls (n = 50) without CVD risk factors. Only high sensitivity CRP was increased in interictal sera of migraineurs [20]. Thus, the present and previous studies advocated that unfavorable serum lipid profile was the most common CVD risk profile of migraineurs among many ethnics, including Europe, North American and Japan.…”

“…In addition, latelife migraineurs had no statistical changes of BP [13]. Other European studies mentioned the controversial result of CVD risk factors [18][19][20]. An Italian populationbased study (age ≥ 45 years) showed that serum levels of TC and LDL-C were increased significantly in migraineurs (n = 151) more than nonmigraineurs (n = 1658) [18].…”

“…Potential mechanisms of increased risk for ischemic stroke and CVD have been postulated in migraineurs [5,9,[14][15][16]. Distinct backgrounds of CVD risk profile were highlighted in European and North American migraineurs [10,13,[17][18][19][20]. However, little is known about CVD risk factors in large number of Asian migraineurs.…”

The role of the endothelium in migraine

“…In a study of endothelial activation, Tietjen et al found that compared to controls, women with migraine had evidence of oxidative stress (lower nitrate/nitrite levels) and of both a procoaguable (higher levels of von Willebrand factor [vWF] activity and tissue plasminogen activator [tPA] antigen) and pro-inflammatory (higher levels of C-reactive protein [CRP]) milieu during the interictal period (18). The finding of elevated CRP in migraine has been reported in a number of other studies as well (12,(19)(20)(21). Recent reports of migraine-associated elevation of endothelin-1 (ET-1) (12), a vasoconstrictive peptide produced by (VSMCs), calls to mind earlier findings from an in vivo rat model showing ET-1 to be a potent inducer of cortical spreading depression, the neurophysiological correlate of migraine aura (22).…”

The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

“…Likewise, substance P which has been expressed in fat cells, may lead to adipocytes fat pool enlargement of and so the pro-inflammatory status accompanied with severe obesity (51). Moreover, the high concentration of pro-inflammatory adipocytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), which is together with excessive levels of adiposity (52), are increased with the begin of migraine headache attacks (53). Also the excessive amount of C-reactive protein (CRP) in systemic inflammation are further increased in both migraine and obese patients (54).…”