Increased Cell Apoptosis of Urothelium Mediated by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome

Shie, Jia-Heng; Liu, Hsin-Tzu; Kuo, Hann‐Chorng

doi:10.1016/j.urology.2011.09.049

Cited by 97 publications

(111 citation statements)

References 29 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…P38 mitogen-activated protein kinase might be an important mediator of the antiproliferative factor in the bladder urothelial cells [23]. Increased levels of the apoptotic signaling molecules, including Bax, cleaved caspase-3, and Bad were elevated in the IC/BPS bladder tissues [24]. The apoptosis in IC/BPS bladders might be due to upregulation of inflammatory signals.…”

Section: Chronic Inflammation and Apoptosismentioning

confidence: 99%

Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

Jhang

Kuo

2016

Int Neurourol J

Self Cite

View full text Add to dashboard Cite

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a heterogeneous syndrome which is usually characterized by urinary frequency, nocturia, and bladder pain. Several pathomechanisms have been proposed, including uroepithelial dysfunction, mast cell activation, neurogenic inflammation, autoimmunity, and occult urinary tract infections. It is possible that an inflammatory process alters regulation of urothelial homeostasis and results in dysfunction of the bladder epithelium. Different phenotypes of IC/BPS have been explored including Hunner and non-Hunner type IC, hypersensitive bladder, and bladder pain both with and without functional somatic syndrome. Different gene expressions have also been found in different IC phenotypes. Abnormal expressions of uroplakin, chondroitin sulfate and adhesive protein E-cadherin, tight junction protein zonula occludens-1 in IC/BPS bladder suggest abnormal epithelial differentiation in this bladder disease. Analysis of inflammatory proteins, or cytokines in the urine or serum provides another diagnostic foundation forIC/BPS subtypes. The involvement of IC/BPS in systemic functional somatic syndrome and other pelvic organ diseases might also subdivide subtypes of IC/BPS. Chronic inflammation, increased urothelial apoptosis, and abnormal urothelial function are closely associated in IC bladders. This article reviews recent research on the pathomechanisms of IC, which might help us in mapping the heterogeneity of the disease.

show abstract

Section: Chronic Inflammation and Apoptosismentioning

confidence: 99%

Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

Jhang

Kuo

2016

Int Neurourol J

Self Cite

View full text Add to dashboard Cite

show abstract

“…We found that BPS/IC was significantly associated with previous statin use, and the Although there is no consensus on a mechanism to explain the underlying cause of BPS/IC, several pathophysiologic mechanisms have been proposed, including epithelial dysfunction, mast cell activation, and neurogenic inflammation [19][20][21] . In addition, many recent studies reported that a higher level of cell apoptosis in the urothelium was associated with inflammation in patients with BPS/IC [22][23][24][25] . We proposed 3 possible explanations for the association between statin use and BPS/IC detected in this study.…”

Section: Discussionmentioning

confidence: 99%

Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study

Huang

Chung

Lin³

et al. 2015

Urol Int

View full text Add to dashboard Cite

Introduction: Statin may induce epithelial dysfunction of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. Subjects and Methods: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. Results: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for diabetes, hypertension, coronary heart disease, obesity, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. Conclusion: We concluded that there was an association between statin use and BPS/IC.

show abstract

“…Tryptase and tumor necrosis factor a induced endothelial expression of intracellular adhesion molecules, suggesting mast cells play an important role in blood vessel permeability and glomerulations in patients with IC/BPS. 18,19 In preliminary studies, we found that the angiogenesis marker interleukin-8 and VEGF were suppressed under onabotulinumtoxinA therapy. 20 According to our preliminary results (protein array and western blotting), we found that the degree of glomerulations and angiogenic factors could be reduced because of the inflammatory suppression by repeated onabotulinumtoxinA injections in some patients with IC/BPS.…”

Section: Commentmentioning

confidence: 98%

“…19 Moreover, the molecular mechanism of apoptosis in IC/BPS bladders was tumor necrosis factor-a and p38 MAPK mediated. p38 MAPK is a protein kinase that coordinates the cellular responses to many types of stresses, including those that trigger oxidative stress.…”

Section: Commentmentioning

confidence: 99%

Down Regulation of Vascular Endothelial Growth Factor Is Associated With Decreased Inflammation After Intravesical OnabotulinumtoxinA Injections Combined With Hydrodistention for Patients With Interstitial Cystitis—Clinical Results and Immunohistochemistry Analysis

Peng

Jhang

Shie

et al. 2013

Urology

Self Cite

View full text Add to dashboard Cite

Increased Cell Apoptosis of Urothelium Mediated by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome

Cited by 97 publications

References 29 publications

Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study

Down Regulation of Vascular Endothelial Growth Factor Is Associated With Decreased Inflammation After Intravesical OnabotulinumtoxinA Injections Combined With Hydrodistention for Patients With Interstitial Cystitis—Clinical Results and Immunohistochemistry Analysis

Contact Info

Product

Resources

About