Increased chromium and nickel content in lung tissue

Kollmeier, H.; Witting, Ch.; Seemann, J.; Wittig, Peter; Rothe, R.E.

doi:10.1007/bf00402735

Cited by 33 publications

(15 citation statements)

References 8 publications

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“…Cigarette smoking might increase the pulmonary levels of these metals through the inhalation of metals contained in cigarette smoke, through a reduction in mucociliary clearance and in the function of macrophages in the lungs, and by causing emphysema (PaÈ aÈ kkoÈ et al 1989). Although the in¯uence of smoking on pulmonary Cd and Cr contents has been well established (Lewis et al 1972;Baumgardt et al 1986;PaÈ aÈ kkoÈ et al 1989;Kollmeier et al 1990a,b), its eect on pulmonary Ni and Pb contents remains a matter of controversy (Zielhuis et al 1977;Kollmeier et al 1985Kollmeier et al , 1990a. Nonetheless, the present results suggest that smoking might to some extent be responsible for the pulmonary Ni and Pb content.…”

Section: Discussioncontrasting

confidence: 41%

Pulmonary metal distribution in urban dwellers

Tsuchiyama

Hisanaga²,

Shibata

et al. 1997

International Archives of Occupational and Environmental Health

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To clarify the factors influencing the concentrations and distribution of metal elements in the lung, we analyzed the following 8 metals in the 5 lung lobes of 17 autopsied urban dwellers by flame or flameless atomic absorption spectrometry: aluminum (Al), cadmium (Cd), chromium (Cr), nickel (Ni), lead (Pb), manganese (Mn), copper (Cu), and Zinc (Zn). The arithmetic mean value (in micrograms of metal per gram of dry weight) calculated for five lobar metal concentrations in each subject ranged from 80 to 681 for Al, from 0.34 to 3.41 for Cd, from 0.41 to 12.7 for Cr, from 0.22 to 1.93 for Ni, from 0.15 to 1.47 for Pb, from 0.64 to 2.36 for Mn, from 2.84 to 7.24 for Cu, and from 40.7 to 77.6 for Zn. The eight metals were classifiable into two groups on the basis of the interindividual and interlobar concentration variations. The first group, consisting of Cu and Zn, was characterized by smaller interindividual variations (co-efficient of variation, CV < 30%) and smaller inter lobar variations (mean CV < 15%). Their levels were not affected significantly by sex, smoking habits, or possible occupational exposure to metal-containing dust. In contrast, the second group, consisting of Al, Cd, Cr, Ni, Pb, and Mn, exhibited larger interindividual variations (CV > 45%) and larger interlobar variations (mean CV > 25%). Concentrations of these metals, except for Cd, tended to be higher in the upper lobes than in the lower lobes. The concentrations of Al and Cr were significantly higher in men than in women. Smoking significantly elevated the levels of Cr, Cd, Ni, and Pb, and the concentrations of Al, Cr, Ni, and Mn were higher in subjects with possible occupational exposure to metal-containing dust than in those without such exposure. However, the interlobar distribution patterns of the metals did not seem to be influenced by sex, smoking habits, or occupational exposure to metal-containing dust.

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Section: Discussioncontrasting

confidence: 41%

Pulmonary metal distribution in urban dwellers

Tsuchiyama

Hisanaga²,

Shibata

et al. 1997

International Archives of Occupational and Environmental Health

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“…Because the latency period between occupational exposure and manifestation of malignant disease is generally many years, it is often For the evaluation of the precision and the accuracy of the analytical methods animal as well as human lung tissue homogenates were used. Kollmeier et al [1985], and Baumgardt et al [1986] have also pointed out the importance of such determinations. Since Cr and Ni must be regarded as metals of ubiquitous occurrence today, particularly owing to increasing industrialization, the evaluation of norm values and ranges is an important precondition for the appraisal of Cr and Ni accumulation in pulmonary tissue that may be related to occupational exposure.…”

Section: Discussionmentioning

confidence: 96%

“…Quantitative determination of Cr and Ni in pulmonary tissue can provide important additional information. Zober et al [1984], Turhan et a1 [1985], Kollmeier et al [1985], and Baumgardt et al [1986] have also pointed out the importance of such determinations.…”

Section: Discussionmentioning

confidence: 99%

Problems in establishing norm values for nickel and chromium concentrations in human pulmonary tissue

Raithel¹,

Ebner²,

Schaller³

et al. 1987

American J Industrial Med

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In 15 random autopsies, nickel (Ni) and chromium (Cr) were determined quantitatively by atomic absorption spectrometry (AAS) in human lung tissue to evaluate norm values. None of the deceased persons had had an occupational exposure to Cr or Ni or their compounds. In all, 22 tissue samples were taken from each lung at specific topographical anatomical locations. The analytical procedure is described in detail. The results showed substantial variation in concentrations both within a single lung and also between individuals. Median values found were 204 ng/g for Cr and 25.6 ng/g for Ni. Topographical concentrations of Cr and Ni were 1.3-1.9 times higher in the upper lung areas. In view of the variability in metal concentration, analysis of only one part of lung tissue is not sufficient for determining the content of the entire lung. The evaluation of norm values is an important precondition for appraisal of Cr and Ni accumulation in human pulmonary tissue that may be due to occupational exposure.

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“…102 The concentrations of carcinogenic metals, including oxides of chromium, nickel and cadmium, increase with age. 103,104 Exogenous carbonaceous particles also appear to accumulate progressively with age, but accurate quantification of their numbers has not been achieved.…”

Section: Deposition Retention and Clearance Of Particulatesmentioning

confidence: 99%