Increased circulating levels of α<sub>1</sub>-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

Welle, Ida; Bakke, Per; Eide, Geir Egil; Fagerhol, Magne K.; Omenaas, Ernst; Gulsvik, Amund

doi:10.1183/09031936.01.00067501

Cited by 17 publications

(14 citation statements)

References 33 publications

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“…A number of hypotheses have been suggested. It has been reported that Alfa -1 antitrypsin is inversely associated with an alteration of gas exchange in the lungs [76]. As the pro inflammatory IL-6 is largely implicated in the synthesis of CRP and also alfa-1 antitrypsin, fibrinogen, and haptoglobin, IL-6 may play a particularly important role in the mechanisms leading to reduced pulmonary function.…”

Section: Discussionmentioning

confidence: 99%

Association Between C Reactive Protein and Asthma

Obaidi¹,

Samarai²,

Jawad³

2010

Tur Toraks Der

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Amaç: Yapılan çalışmalar sistemik inflamasyon belirteçleri ve akciğer fonksiyonları arasında ters bir orantı olduğunu göstermekte-dir. Bu çalışmada C-reaktif proteinin (CRP) serum düzeyi, vücut kitle indeksi ve astım arasındaki ilişkiyi belirlemeyi hedefledik. Gereç ve Yöntem:Bu çalışmada 178 astım hastasında ve 50 sağlıklı kontrol grubunda CRP düzeyi belirlendi. Astım hastaları-nın 126'sı stabil evrede ve 52'si ise atak dönemindeydi. Bulgular:Astım hastalarında kontrol grubuna göre CRP düzeyi-nin istatistiksel düzeyde anlamlı derecede (p<0.05) daha yüksek olduğu görüldü. Atak dönemindeki astım hastalarında ise serum CRP düzeylerinin stabil devredeki astım hastalarından anlamlı derecede daha yüksek olduğu görüldü (p<0.05). Astım hastalarında FEV1 değeri serum CRP düzeyi ile ters bir orantı gösteri-yordu. Astım hastalarında, serum CRP düzeyi ve vücut kitle indeksi arasında istatistiksel düzeyde anlamlı bir ilişki vardı (p<0.0001). Ayrıca ortalama vücut kitle indeksinin astım hastalarında kontrol gruba göre daha yüksek olduğu görüldü. Material and Method:In the present study, CRP was determined in 178 patients with asthma and 50 healthy control subjects. Of all asthmatics, 126 had stable asthma and 52 had asthma during exacerbation.Results: CRP was significantly higher (p<0.05) in asthmatic patients as compared to the control group. In asthmatics with exacerbation, serum CRP was significantly higher than in stable asthmatic patients and control subjects. FEV1 was significantly inversely correlated with serum CRP in asthmatic patients. In asthmatic patients there was a significant (p<0.0001) association between serum level of CRP and body mass index. Furthermore, the mean BMI was significantly higher in asthmatic patients than that in control subjects. Conclusion:Serum CRP may be a non specific marker of asthma and its exacerbation. In addition, obesity could be a risk factor for asthma. (Tur Toraks Der 2010; 11: 98-104)

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Section: Discussionmentioning

confidence: 99%

Association Between C Reactive Protein and Asthma

Obaidi¹,

Samarai²,

Jawad³

2010

Tur Toraks Der

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“…Single-breath diffusing capacity of carbon monoxide (TL,CO), a marker of gas diffusion in the lungs, is reduced in a 1 -AT deficient patients [17]. WELLE et al [18] examined the relationship between TL,CO and serum levels of a 1 -AT and calprotectin, a plasma marker for neutrophil activation, in a stratified sample (n=1,121) from the Norwegian population. An inverse relationship was found between a 1 -AT and FEV1 % pred, and between a 1 -AT and TL,CO, though only significant in females.…”

Section: Markers Of Systemic Inflammation In Chronic Obstructive Pulmmentioning

confidence: 99%

Chronic obstructive pulmonary disease as a systemic disease: an epidemiological perspective: Fig. 1.—

Andreassen

Vestbo²

2003

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) has been increasingly recognised as a systemic disease. The hormonal, metabolic and musculoskeletal implications of the generalised processes involving oxidative stress, inflammatory mediators, cytokines, and endocrine hormones have only begun to be understood.Only a few studies have looked into the epidemiology of inflammatory markers in patients with chronic obstructive pulmonary disease. Common extrapulmonary effects of chronic obstructive pulmonary disease include skeletal muscle dysfunction, wasting and osteoporosis. The resulting effects of a systemic inflammation can be measured at specific extrapulmonary organs such as skeletal muscle or in more general terms using body composition, body weight or derived measures, and only a few studies have set the parameters in an epidemiological context. Nevertheless, these studies indicate an association between inflammatory markers and forced expiratory volume in one second not only in subjects with severe chronic obstructive pulmonary disease. Also, it is increasingly clear that systemic markers in chronic obstructive pulmonary disease have important effects on prognosis. Eur Respir J 2003; 22: Suppl. 46, 2s-4s.

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“…79 As it is the case in other systemic markers, blood levels of alpha 1 -AT have been directly related to the degree of the lung function impairment. 100 Homocysteine (Hcys) is a thiol with high reactivity to proteins. Because it degrades the lysine and cysteine components, protein function becomes impaired.…”

Section: Il-1mentioning

confidence: 99%

Systemic Inflammation in COPD

Gea

Barreiro

Orozco-Levi

2009

Clinical Pulmonary Medicine

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Chronic obstructive pulmonary disease (COPD) has classically been considered to be an intrathoracic condition characterized by nonfully reversible airway obstruction. However, COPD has been recently recognized as a multicomponent disorder, associated with systemic inflammation and extrapulmonary manifestations. The present review analyzes current evidence on systemic inflammation concomitant with COPD, and discusses its possible biologic and clinical implications as well as possible therapeutic approaches. Some degree of systemic inflammation appears to be present in most of COPD patients, being characterized by the presence of increased plasma levels of proinflammatory mediators and/or markers (such as C-reactive protein, fibrinogen, different cytokines, and white cells). Many of these biomarkers further increase during exacerbations, and can be modulated by exercise, smoking habit, and different drugs. Moreover, patients with COPD frequently exhibit extrapulmonary manifestations. This includes nutritional-body composition abnormalities, skeletal muscle dysfunction, osteoporosis, cardiovascular events, hemostatic disorders, renal dysfunction, and hormonal dysregulation. Further studies are needed to elucidate the mechanisms and consequences of the systemic inflammatory response and extrapulmonary manifestations associated with COPD, thus contributing to the development of novel therapeutic strategies.

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Increased circulating levels of α₁-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

Cited by 17 publications

References 33 publications

Association Between C Reactive Protein and Asthma

Association Between C Reactive Protein and Asthma

Chronic obstructive pulmonary disease as a systemic disease: an epidemiological perspective: Fig. 1.—

Systemic Inflammation in COPD

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Increased circulating levels of α1-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

Cited by 17 publications

References 33 publications

Association Between C Reactive Protein and Asthma

Association Between C Reactive Protein and Asthma

Chronic obstructive pulmonary disease as a systemic disease: an epidemiological perspective: Fig. 1.—

Systemic Inflammation in COPD

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Increased circulating levels of α₁-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs