Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome

Temür, Muzaffer; Yılmaz, Özgür; Aksun, Saliha; Özbay, Pelin Özün; Çalan, Mehmet; Küme, Tuncay; Karakulak, Murat; Korkmaz, Hüseyin Anıl

doi:10.1530/endoabs.37.ep139

Cited by 3 publications

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“…In a previous study, UCN3 levels were investigated in subjects with PCOS, which is a metabolic disorder associated with insulin resistance. Although, the results showed that UCN3 levels were elevated in subjects with PCOS, UCN3 levels were not in association with insulin resistance . Additionally, it was reported that UCN3 did not display any link with body weight and lipid profiles, but it was only positively correlated with the inflammatory marker hs‐CRP in subjects with PCOS.…”

Section: Discussionmentioning

confidence: 77%

Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus

Alarslan

Kocabaş

Demir

et al. 2020

Journal of Diabetes

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Background: Urocortin 3 (UCN3) is a peptide hormone playing a pivotal role in glucose and lipid metabolisms. However, its clinical implications remain unclear. Our aims were to investigate the altered levels of UCN3 in newly diagnosed type 2 diabetes mellitus (nT2DM) patients in comparison to subjects with normal glucose tolerance (NGT) and to determine the presence of any possible link between UCN3 levels and metabolic parameters.Methods: Eighty nT2DM and 80 age-, body mass index (BMI)-, and gendermatched NGT subjects were enrolled into this case-control study. The circulating UCN3 levels were measured using the enzyme-linked immunoabsorbent assay (ELISA). Metabolic parameters of enrolled subjects were also determined. A standard 75-g 2-hour oral glucose tolerance test was used for diagnosis of type 2 diabetes mellitus (T2DM). Results: UCN3 levels were higher in subjects with nT2DM than in controls (115.64 ± 39.26 vs 86.16 ± 22.81 pg/mL, P < .001). UCN3 levels were increased in subjects with metabolic syndrome compared to subjects without metabolic syndrome in both nT2DM and NGT groups. UCN3 levels showed a positive correlation with BMI in both groups. Moreover, UCN3 levels were positively and independently associated with insulin, fasting blood glucose, insulin resistance, 2-hour plasma glucose, glycosylated hemoglobin, and triglycerides, whereas UCN3 levels were negatively and independently associated with high-density lipoprotein cholesterol. According to logistic regression analysis, increased risk of T2DM and metabolic syndrome were parallel with the highest elevated levels of UCN3.Conclusions: Increased levels of UCN3 are associated with unfavorable metabolic profiles in T2DM, indicating a potential role of UCN3 in glucose and lipid metabolisms in T2DM. Highlights• Urocortin 3 (UCN3) may play a crucial role in glucose and lipid metabolisms.

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Section: Discussionmentioning

confidence: 77%

Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus

Alarslan

Kocabaş

Demir

et al. 2020

Journal of Diabetes

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“…CRH family members are involved in the regulation of various physiological processes through autocrine/paracrine mechanisms (8,16), including food intake and energy balance (5,6,13‐15), inflammation (9,30), and stress response (5). The present study demonstrated an altered pattern of UCNs in children associated with children’s body weight.…”

Section: Discussionmentioning

confidence: 99%

Circulating levels of urocortin neuropeptides are impaired in children with overweight

Kavalakatt

Khadir

Madhu

et al. 2022

Obesity

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The rise in the prevalence of childhood obesity is an increasing public health problem worldwide, particularly in societies that have witnessed a profound change in lifestyle associated with higher food intake and decreased physical activity during the past few decades (1). The number of children aged 5 to 19 years old living with obesity in 2019 is estimated to be 158 million worldwide and is expected to reach approximately 254 million by 2030 (2). These changes are accompanied by a rise in obesity-related metabolic disorders, including insulin resistance, dyslipidemia, and hormonal dysregulation (3). More alarmingly, nearly 80% of children and

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“…21,39,42,43 Interestingly, we did not find remarkable differences among Ucn types and in their association with specific cardiovascular diseases. Moreover, blood Ucn levels appear to increase in a number of other general systemic challenges, including metabolic syndrome, 49 PCOS, 53,54 or type 2 diabetes mellitus. 48,49 Thus, increases in Ucn levels may not even be specific for cardiovascular disorders or HF.…”

Section: Discussionmentioning

confidence: 99%

Assessment of clinical data on urocortins and their therapeutic potential in cardiovascular diseases: A systematic review and meta‐analysis

Kovács

Farkas

Soós

et al. 2021

Clinical Translational Sci

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Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome

Cited by 3 publications

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Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus

Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus

Circulating levels of urocortin neuropeptides are impaired in children with overweight

Assessment of clinical data on urocortins and their therapeutic potential in cardiovascular diseases: A systematic review and meta‐analysis

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