Increased Colonic Permeability in Patients with Ulcerative Colitis: An in Vitro Study

Nejdfors, Pernilla; Wang, Q.; Ekelund, Mats; Weström, Björn; Jansson, Ove; Lindstrom, C.; Karlsson, Börje W.; Jeppsson, Bengt

doi:10.1080/00365529850171701

Cited by 35 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A reduced epithelial barrier function leading to abrogation of immunological tolerance against normally innocuous antigens, including dietary proteins and components of the indigenous bacterial flora, appears to be a significant immunopathogenic mechanism in several important mucosal disorders such as gluten-sensitive enteropathy (celiac disease) 30 and IBD 3132. One marker of this untoward development is lack of mucosal integrity 33 and increased production of IgA and IgG antibodies to normally encountered luminal antigens, particularly against gluten in celiac disease 30 and E . coli in IBD 3134.…”

Section: Resultsmentioning

confidence: 99%

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

Johansen

Pekna

Norderhaug

et al. 1999

The Journal of Experimental Medicine

372

307

View full text Add to dashboard Cite

Mucosal surfaces are protected specifically by secretory immunoglobulin A (SIgA) and SIgM generated through external translocation of locally produced dimeric IgA and pentameric IgM. Their active transport is mediated by the epithelial polymeric Ig receptor (pIgR), also called the transmembrane secretory component. Paracellular passive external transfer of systemic and locally produced antibodies also provides mucosal protection, making the biological importance of secretory immunity difficult to assess. Here we report complete lack of active external IgA and IgM translocation in pIgR knockout mice, indicating no redundancy in epithelial transport mechanisms. The knockout mice were of normal size and fertility but had increased serum IgG levels, including antibodies to Escherichia coli, suggesting undue triggering of systemic immunity. Deterioration of their epithelial barrier function in the absence of SIgA (and SIgM) was further attested to by elevated levels of albumin in their saliva and feces, reflecting leakage of serum proteins. Thus, SIgA did not appear to be essential for health under the antigen exposure conditions of these experimental animals. Nevertheless, our results showed that SIgA contributes to maintenance of mucosal homeostasis. Production of SIgA might therefore be a variable in the initiation of human immunopathology such as inflammatory bowel disease or gluten-sensitive enteropathy.

show abstract

Section: Resultsmentioning

confidence: 99%

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

Johansen

Pekna

Norderhaug

et al. 1999

The Journal of Experimental Medicine

372

307

View full text Add to dashboard Cite

show abstract

“…Mannitol is passively transported along a concentration gradient by paracellular and transcellular pathways in the colonic mucosa of dogs. 16 Because there is no active transport of mannitol in the colonic mucosa of dogs, increased permeability to mannitol is likely a result of compromised functional integrity of intercellular tight junctions of the colonic mucosa. Oral administration of indomethacin, an NSAID, uncouples oxidative phosphorylation in the mitochondria of epithelial cells of the intestinal mucosa of rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of carprofen on the integrity and barrier function of canine colonic mucosa

Briere

Hosgood²,

Morgan³

et al. 2008

ajvr

View full text Add to dashboard Cite

show abstract

“…Patients with ulcerative colitis have increased intestinal permeability, which is most likely caused by the ulcerations observed in ulcerative colitis, causing diarrhea, a primary exudate of the disease [79]. The annual incidence of ulcerative colitis in the United States during the period 1996-2002 was 12 cases per 100,000 and has risen in recent decades [80].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of nicotine in obesity and ulcerative colitis

2011

View full text Add to dashboard Cite

Cigarette smoke is a major risk factor for a number of diseases including lung cancer and respiratory infections. Paradoxically, it also contains nicotine, an anti-inflammatory alkaloid. There is increasing evidence that smokers have a lower incidence of some inflammatory diseases, including ulcerative colitis, and the protective effect involves the activation of a cholinergic anti-inflammatory pathway that requires the α7 nicotinic acetylcholine receptor (α7nAChR) on immune cells. Obesity is characterized by chronic low-grade inflammation, which contributes to insulin resistance. Nicotine significantly improves glucose homeostasis and insulin sensitivity in genetically obese and diet-induced obese mice, which is associated with suppressed adipose tissue inflammation. Inflammation that results in disruption of the epithelial barrier is a hallmark of inflammatory bowel disease, and nicotine is protective in ulcerative colitis. This article summarizes current evidence for the anti-inflammatory effects of nicotine in obesity and ulcerative colitis. Selective agonists for the α7nAChR could represent a promising pharmacological strategy for the treatment of inflammation in obesity and ulcerative colitis. Nevertheless, we should keep in mind that the anti-inflammatory effects of nicotine could be mediated via the expression of several nAChRs on a particular target cell.

show abstract

Increased Colonic Permeability in Patients with Ulcerative Colitis: An in Vitro Study

Abstract: The results suggest a derangement of the colonic barrier, as evidenced by an increased mucosal permeability in both chronic and acute colitis.

Cited by 35 publications

References 22 publications

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

Effects of carprofen on the integrity and barrier function of canine colonic mucosa

Anti-inflammatory effects of nicotine in obesity and ulcerative colitis

Contact Info

Product

Resources

About