Increased concentration of serum periostin is associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage

Luo, Weijian; Wang, Hao; Hu, Jiliang

doi:10.1002/jcla.22389

Cited by 16 publications

(16 citation statements)

References 26 publications

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“…Previous studies found that increased periostin levels were associated with clinical severity and poor outcome in patients with traumatic brain injury 17 , aneurysmal subarachnoid haemorrhage 18 , and ICH 16 . In the present study, the increased periostin levels observed in the first 6 days or within 4 weeks after IS were correlated with the NIHSS scores, indicating that the new accumulation of periostin in the circulation might reflect the degree of IS severity.…”

Section: Discussionmentioning

confidence: 95%

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Bao

Shen

et al. 2018

Sci Rep

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Increasing evidence supports the involvement of periostin in the pathophysiological processes of stroke and atherosclerosis. The aim of this study was to assess circulating periostin levels at different times after large-artery atherosclerotic (LAA) stroke and their association with stroke. Serum periostin levels were measured using enzyme-linked immunosorbent assay on day 1 in 162 patients with LAA stroke and in 108 age- and sex-matched controls, on day 6 after stroke in 134 patients, and during the 4th week after stroke in 46 of the 162 patients. Stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS), and the stroke volume was measured. Outcome at 3 months was measured using the modified Rankin Scale (mRS). Our results indicated that periostin levels increased significantly on day 6 after stroke, and this increasing trend persisted for at least 4 weeks after the event. In addition, the increase in periostin levels was positively correlated with the NIHSS scores and stroke volume, but not with the mRS scores after adjusting for the NIHSS scores. In conclusion, these findings suggest that the increase in serum periostin levels observed after stroke may be associated with the stroke severity in patients with LAA stroke.

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Section: Discussionmentioning

confidence: 95%

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Bao

Shen

et al. 2018

Sci Rep

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“…Thus, post-SAH increases in POSTN may cause EBI, which in turn may lead to DCI with no vasospasm [13]. In fact, a previous clinical study reported positive correlation between admission WFNS grade, which may reflect the severity of EBI, and pretreatment peripheral blood POSTN levels [14]. In the present study, admission WFNS grade and plasma POSTN levels at days 1-3 were negatively correlated, but this may be because poor-grade patients more frequently underwent CSF drainage, resulting in lower plasma POSTN levels.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we reported that POSTN was upregulated in cerebral cortex after SAH in mice and was responsible for early brain injury (EBI) in terms of blood-brain barrier (BBB) disruption [13]. There has been only one paper published in a clinical setting, in which admission and pretreatment peripheral blood levels of POSTN were related to clinical severity, DCI, and poor outcomes after aneurysmal SAH [14]. However, it remains unknown how peripheral blood POSTN levels change with time, and if various treatments that are performed for aneurysmal obliteration or prevention of DCI influence peripheral blood POSTN levels.…”

Section: Introductionmentioning

confidence: 99%

Plasma Periostin and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

et al. 2019

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Delayed cerebral ischemia (DCI) is a serious complication of aneurysmal subarachnoid hemorrhage (SAH). Matricellular protein periostin (POSTN) has been found to be upregulated and linked with early brain injury after experimental SAH. The aim of the present study was to investigate the relationship between plasma POSTN levels and various clinical factors including serum levels of C-reactive protein (CRP), an inflammatory marker, in 109 consecutive SAH patients whose POSTN levels were measured at days 1-12 after aneurysmal obliteration. DCI developed in 16 patients associated with higher incidence of angiographic vasospasm, cerebral infarction, and 90-day worse outcomes. POSTN levels peaked at days 4-6 before DCI development. Cerebrospinal fluid (CSF) drainage was associated with reduced POSTN levels, but did not influence CRP levels. There was no correlation between POSTN levels and other treatments or CRP levels. To predict DCI development, receiver-operating characteristic curves indicated that the most reasonable cutoff POSTN levels were obtained at days 1-3 in patients without CSF drainage (80.5 ng/ml; specificity, 77.6%; sensitivity, 85.7%). Multivariate analyses using variables obtained by day 3 revealed that POSTN level was an independent predictor of DCI. POSTN levels over the cutoff value were associated with higher incidence of DCI, but not angiographic vasospasm. This study shows for the first time that CSF drainage may reduce plasma POSTN levels, and that POSTN levels may increase prior to the development of DCI with and without vasospasm irrespective of systemic inflammatory reactions in clinical settings. These findings suggest POSTN as a new therapeutic molecular target against post-SAH DCI.

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“…The apparent discrepancy may be resolved by future studies to clarify how periostin relates with each integrin subtype in cerebrovascular diseases. In a clinical setting, a higher serum periostin level at admission was associated with worse initial neurological status, greater hemorrhage volume, more frequent development of DCI, and worse clinical outcomes in patients with aneurysmal SAH ( 116 ). In addition, plasma periostin levels increased before the development of DCI, irrespective of the presence or absence of CVS ( 108 , 117 ).…”

Section: Contribution Of Other Mcps To Regulating Tnc Expression In Smentioning

confidence: 99%

The Role of Tenascin-C in Tissue Injury and Repair After Stroke

Okada

Suzuki

2021

Front. Immunol.

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Stroke is still one of the most common causes for mortality and morbidity worldwide. Following acute stroke onset, biochemical and cellular changes induce further brain injury such as neuroinflammation, cell death, and blood-brain barrier disruption. Matricellular proteins are non-structural proteins induced by many stimuli and tissue damage including stroke induction, while its levels are generally low in a normal physiological condition in adult tissues. Currently, a matricellular protein tenascin-C (TNC) is considered to be an important inducer to promote neuroinflammatory cascades and the resultant pathology in stroke. TNC is upregulated in cerebral arteries and brain tissues including astrocytes, neurons, and brain capillary endothelial cells following subarachnoid hemorrhage (SAH). TNC may be involved in blood-brain barrier disruption, neuronal apoptosis, and cerebral vasospasm via the activation of mitogen-activated protein kinases and nuclear factor-kappa B following SAH. In addition, post-SAH TNC levels in cerebrospinal fluid predicted the development of delayed cerebral ischemia and angiographic vasospasm in clinical settings. On the other hand, TNC is reported to promote fibrosis and exert repair effects for an experimental aneurysm via macrophages-induced migration and proliferation of smooth muscle cells. The authors review TNC-induced inflammatory signal cascades and the relationships with other matricellular proteins in stroke-related pathology.

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Increased concentration of serum periostin is associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage

Abstract: Elevated serum periostin concentrations are significantly associated with clinical severity and poor outcome of aSAH patients, which indicate serum periostin can be used as a prognostic biomarker in patients with aSAH.

Cited by 16 publications

References 26 publications

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Plasma Periostin and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

The Role of Tenascin-C in Tissue Injury and Repair After Stroke

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