Increased Corneal Hysteresis After Corneal Collagen Crosslinking

Rehnman, Jeannette Beckman; Behndig, Anders; Hallberg, Per; Lindén, Christina

doi:10.1001/jamaophthalmol.2014.3029

Cited by 21 publications

(19 citation statements)

References 38 publications

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“…8 Other technologies such as the applanation resonance tonometer demonstrate increased ocular hysteresis following cross-linking. 9 Repeatability and comparability studies may provide confirming data. Computer simulation modeling may provide insight into the biomechanical changes following cross-linking and provide better clinical metrics to follow.…”

Section: Measuring Treatment Success With Cross-linkingmentioning

confidence: 91%

Corneal cross-linking

Randleman

Khandelwal

Hafezi

2015

Survey of Ophthalmology

164

113

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Since its inception in the late 1990s, corneal cross-linking has grown from an interesting concept to a primary treatment for corneal ectatic disease worldwide. Using a combination of ultraviolet-A light and a chromophore (vitamin B2, riboflavin), the cornea can be stiffened, usually with a single application, and progressive thinning diseases such as keratoconus arrested. Despite being in clinical use for many years, some of the underlying processes, such as the role of oxygen and the optimal treatment times, are still being worked out. More than a treatment technique, corneal cross-links represent a physiological principle of connective tissue, which may explain the enormous versatility of the method. We highlight the history of corneal cross-linking, the scientific underpinnings of current techniques, evolving clinical treatment parameters, and the use of cross-linking in combination with refractive surgery and for the treatment of infectious keratitis.

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Section: Measuring Treatment Success With Cross-linkingmentioning

confidence: 91%

Corneal cross-linking

Randleman

Khandelwal

Hafezi

2015

Survey of Ophthalmology

164

113

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“…Patients were included in running numbers according to the list; an even number was treated with CXL and an odd number with PiXL 13. If both eyes of a patient were included (n=13), the second eye always received the other treatment.…”

Section: Methodsmentioning

confidence: 99%

“…Inclusion required a diagnosis of progressive keratoconus with a minimum corneal thickness of 400 µm at the thinnest point after epithelial removal. The keratoconus diagnosis was based on the Amsler-Krumeich grading14 and the ‘Total Deviation’ keratoconus quantification value from the ‘Belin-Ambrosio enhanced ectasia’ measurements of the Pentacam HR, plus an altered red reflex and/or distortion of the keratometric mires 13 15. Disease progression was verified by increasing corneal steepness (increase in K max of ≥1 D in 1 year) and/or thinning of the cornea on repeated Scheimpflug tomography measurements in 41 eyes; in 9 eyes, the progression was verified by increasing keratometric astigmatism and corneal steepness and decreasing best-spectacle-corrected visual acuity.…”

Section: Methodsmentioning

confidence: 99%

Refractive improvements and safety with topography-guided corneal crosslinking for keratoconus: 1-year results

et al. 2016

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“…23,24 The ORA is most commonly used in the clinic for evaluating corneal biomechanics, and there are many studies based on ORA results after various ocular pathologies and eye surgeries. 9,13,14,15,25,26,27,28 ORA studies performed in keratoconus have reported lower CH and CRF parameters compared with normal eyes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Corneal Biomechanical Changes After Collagen Crosslinking in Patients with Progressive Keratoconus by Ocular Response Analyzer

Küçümen¹,

Şahan²,

Yildirim³

et al. 2018

tjo

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Objectives:To evaluate corneal biomechanics before and after collagen crosslinking (CXL) in patients with progressive keratoconus.Materials and Methods:In this prospective study, CXL was performed under topical anesthesia after removal of the epithelium (epi-off technique) by applying ultraviolet A (UVA) light at a wavelength of 365 nm and power of 3 mW/cm2 or 5.4 joule/cm2. Isoosmolar 0.1% riboflavin solution was administered before and during UVA irradiation. In addition to ophthalmologic examination, ocular response analyzer measurements were performed pre- and postoperatively. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated intraocular pressure (IOPcc), Goldmann-correlated intraocular pressure (IOPg), and central corneal thickness (CCT) were recorded.Results:The study included 35 eyes of 30 patients with progressive keratoconus. The mean age was 28.2±6.5 years and postoperative follow-up time was 20.2±14.7 months (range: 6-74 months). The mean CH was 8.60±1.23 mmHg preoperatively, 8.96±2.05 mmHg in the early postoperative period (1-6 months), (p=0.28) and 8.96±1.28 mmHg in the late postoperative period (10-29 months) (p=0.48). Mean CRF was 7.13±1.50 mmHg preoperatively, 8.48±2.16 mmHg in the early postoperative period (p=0.009), and 7.71±1.29 mmHg in the late postoperative period (p=0.40). Mean IOPcc was 12.78±2.34 mmHg preoperatively, 15.38±4.21 mmHg in the early postoperative period (p=0.12) and 13.68±3.61 mmHg in the late postoperative period (p=0.48). Mean IOPg was 9.56±2.73 mmHg preoperatively, 13.01±4.45 mmHg in the early postoperative period (p=0.046), and 10.86±3.47 mmHg in the late postoperative period (p=0.44). Mean CCT was 484.43±41.26 µm preoperatively, 474.16±64.74 µm in the early postoperative period (p=0.70), and 470.38±33.64 µm in late postoperative period (p=0.71).Conclusion:CXL is a treatment modality believed to affect corneal biomechanics in keratoconus, but the results of larger patient series with longer follow-up periods may enable a better evaluation.

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Increased Corneal Hysteresis After Corneal Collagen Crosslinking

Abstract: IMPORTANCE A reliable tool for quantification of the biomechanical status of the cornea in conjunction with corneal collagen crosslinking (CXL) treatment is needed.OBJECTIVE To quantify the biomechanical effects of CXL in vivo.

Cited by 21 publications

References 38 publications

Corneal cross-linking

Corneal cross-linking

Refractive improvements and safety with topography-guided corneal crosslinking for keratoconus: 1-year results

Evaluation of Corneal Biomechanical Changes After Collagen Crosslinking in Patients with Progressive Keratoconus by Ocular Response Analyzer

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