Increased Cytosol Aminopeptidase and Lactate Dehydrogenase in Serum Originating From Lymphocytes in Measles and Rubella Infection

Sugaya, Norio; Nirasawa, Mari; Mitamura, Keiko; Takeuchi, Yoshinao; Osano, Mitsuru; Kanno, Takashi

doi:10.1001/archpedi.1988.02150120106051

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…18 An earlier report showed that increases in serum cytosol LAP activity were found in patients with measles and rubella. 19 We have treated several cases of hemophagocytic syndrome showing remarkable increases in serum cytosol LAP activity and ferritin concentration (unpublished data). Cytosol LAP is induced by some cytokines.…”

Section: Discussionmentioning

confidence: 99%

A New Glucose-6-phosphate Dehydrogenase Deficiency Variant, G6PD Mizushima, Showing Increases in Serum Ferritin and Cytosol Leucine Aminopeptidase Levels

Suga

Nagita²,

Takesako³

et al. 2011

Journal of Pediatric Hematology/Oncology

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We made a diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency with a new mutation of 848A→G (exon 8) in a 16-year-old male patient presenting with severe hemolysis. He was administered a diclofenac sodium suppository (50 mg) at the time of first visit to our hospital because of pyrexia. In the acute phase, pyrexia, severe general fatigue, lumbar back pain, hemoglobinuria, and jaundice developed. Laboratory blood examinations showed hemolysis, and remarkable increases in serum ferritin and cytosol leucine aminopeptidase levels. Serum interleukin-6 and interferon-γ levels were also increased. No liver injury was found. He had neonatal jaundice persisting over 3 weeks. He did not have a history of chronic hemolysis or hyperbilirubinemia. Increases in serum ferritin or cytosol leucine aminopeptidase levels in G6PD-deficient patients were not reported earlier. In this case, it is presumed that infection and administration of anti-inflammatory agents induce the hemolytic episode and that hypercytokinemia deteriorates the disease condition.

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Section: Discussionmentioning

confidence: 99%

A New Glucose-6-phosphate Dehydrogenase Deficiency Variant, G6PD Mizushima, Showing Increases in Serum Ferritin and Cytosol Leucine Aminopeptidase Levels

Suga

Nagita²,

Takesako³

et al. 2011

Journal of Pediatric Hematology/Oncology

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show abstract

“…HHV-6 viremia occurred in 40% of the former group and in 14% of the latter group mostly around 2-4 weeks after the transplantations. Measles virus infects human T and B lymphocytes in vivo [Whittle et al, 19781 and human T and B lymphocytes and monocytes in vitro [Sullivan et al, 1975;Joseph et al, 19751, which might result in destruction of the infected cells [Osunkoya et al, 1973;Sugaya et al, 1988;Suga et al, 1990bl and profound immune dysfunction in infected individuals. Measles virus-induced immunosuppression may be qualitatively and quantitatively similar with immunosuppression induced by the conditioning regimen for bone marrow and kidney transplantation.…”

Section: Discussionmentioning

confidence: 99%

Activation of human herpesvirus‐6 in children with acute measles

Suga

Yoshikawa

Asano

et al. 1992

Journal of Medical Virology

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Virological and serological studies were carried out prospectively to evaluate the possible activation of human herpesvirus-6 (HHV-6) in 50 infants and children with acute measles by isolation of HHV-6 from peripheral blood and by determining neutralizing antibodies to the virus. All but 5 patients (90%) were seropositive to HHV-6 in the acute stage of measles and 18 (40%) had a significant increase in HHV-6 antibody titers thereafter, whereas only 2 of 27 patients who were initially seropositive to Epstein-Barr virus (EBV) viral capsid antigen (VCA) had a significant rise in antibody titers to EBV VCA. Among 18 patients with a significant increase in HHV-6 titers, the virus was isolated from the peripheral blood mononuclear cells of three patients in the early convalescent stage of measles. These results indicate that activation of HHV-6 may occur frequently a few weeks after primary infection with the measles virus.

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Increased Cytosol Aminopeptidase and Lactate Dehydrogenase in Serum Originating From Lymphocytes in Measles and Rubella Infection

Cited by 2 publications

References 19 publications

A New Glucose-6-phosphate Dehydrogenase Deficiency Variant, G6PD Mizushima, Showing Increases in Serum Ferritin and Cytosol Leucine Aminopeptidase Levels

A New Glucose-6-phosphate Dehydrogenase Deficiency Variant, G6PD Mizushima, Showing Increases in Serum Ferritin and Cytosol Leucine Aminopeptidase Levels

Activation of human herpesvirus‐6 in children with acute measles

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