Increased depression-like behaviors with dysfunctions in the stress axis and the reward center by free access to highly palatable food

Park, E.; Kim, J.Y.; Lee, J.-H.; Jahng, Jeong Won

doi:10.1016/j.neuroscience.2013.12.054

Cited by 10 publications

(3 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, following exposure to a stressor, studies show that intake of palatable foods reduce signs of stress and anxiety (Pecoraro et al, 2004; La Fleur et al, 2005; Maniam and Morris, 2010, 2012; Ulrich-Lai et al, 2010; Finger et al, 2011, 2012). Interestingly, stress-induced preference for palatable food is often seen in humans (Souquet and Rowland, 1989; Epel et al, 2004; Pecoraro et al, 2004; Christiansen et al, 2011; Gibson, 2012; Merali et al, 2013; Sharma et al, 2013; Sharma and Fulton, 2013; Meye and Adan, 2014; Park et al, 2014; Rho et al, 2014). Notably, this behavior is extended to animals (Dallman et al, 2003, 2005; Cottone et al, 2009).…”

Section: Central Nervous System In Regulation Of Mood Food and Obesitymentioning

confidence: 99%

Mood, food, and obesity

2014

View full text Add to dashboard Cite

Food is a potent natural reward and food intake is a complex process. Reward and gratification associated with food consumption leads to dopamine (DA) production, which in turn activates reward and pleasure centers in the brain. An individual will repeatedly eat a particular food to experience this positive feeling of gratification. This type of repetitive behavior of food intake leads to the activation of brain reward pathways that eventually overrides other signals of satiety and hunger. Thus, a gratification habit through a favorable food leads to overeating and morbid obesity. Overeating and obesity stems from many biological factors engaging both central and peripheral systems in a bi-directional manner involving mood and emotions. Emotional eating and altered mood can also lead to altered food choice and intake leading to overeating and obesity. Research findings from human and animal studies support a two-way link between three concepts, mood, food, and obesity. The focus of this article is to provide an overview of complex nature of food intake where various biological factors link mood, food intake, and brain signaling that engages both peripheral and central nervous system signaling pathways in a bi-directional manner in obesity.

show abstract

Section: Central Nervous System In Regulation Of Mood Food and Obesitymentioning

confidence: 99%

Mood, food, and obesity

2014

View full text Add to dashboard Cite

show abstract

“…[1][2][3] Highly palatable and hypercaloric diets may drive specific alterations to the reward pathways of the brain, impact monoamine signaling in offspring, and reduce serotonergic tone. 4,5 The outcome of these alterations is a positive feedback loop, which drives increased consumption of palatable food, obesity, and further alterations to the reward pathway. 6,7 Similarly, adiposity may have implications for risk and reward pathways in the brain linked to anxiety and depression.…”

Section: Introductionmentioning

confidence: 99%

Obesogenic diets induce anxiety in rodents: A systematic review and meta‐analysis

2021

View full text Add to dashboard Cite

Obesity and mood disorders have been linked in a positive feedback loop. However, due to the bidirectional relationship between obesity and mental health, it is not clear whether anxiety is correlated with or caused by consumption of obesogenic diets.Here, we present a meta-analysis on the effects of dietary manipulation on rodent behavior in the elevated plus maze and open field test, the most common tests of anxiety-like behavior in animal models. The main dataset examined effects of obesogenic diets on time spent in the open and movement around the mazes. Auxiliary datasets examined effects of caloric restriction and protein restriction.Obesogenic diets had a negative effect on the time spent in the open overall. Effects were stronger in males than females. No effect of diet on locomotion was found, indicating that increases in anxiety-like behavior are not due to altered activity levels.No consistent effect of caloric restriction was observed, whereas protein restriction was associated with an increase in the time spent in the open. We show that obesogenic diets have a causative effect on anxiety-like behaviors in rodents, and not via a change in activity. Further studies are required to determine why obesogenic diets induce these behavioral changes.

show abstract

“…Preferring palatable foods seems to alleviate stress and anxiety symptoms (70)(71)(72). Such dietary patterns are observed in both humans and animals (73)(74)(75)(76), suggesting the involvement of a common neurobiological pathway in the decision-making process regarding food choices and eating habits under stress.…”

Section: Emotional Eatingmentioning

confidence: 98%

Dietary habits, depression and obesity: an intricate relationship to explore in pediatric preventive strategies

Calcaterra,

Rossi,

Magenes

et al. 2024

Front. Pediatr.

View full text Add to dashboard Cite

Obesity and depression represent major health problems due to their high prevalence and morbidity rates. Numerous evidences elucidated the connections between dietary habits and the incidence or severity of depression. This overview aims to investigate the intricate relationship between dietary patterns and depression with the objective of elaborating preventive strategies for childhood obesity. Literature data recognized that there is a link between mood and food choices, with certain foods selected for their impact on the brain's reward centers. This behavior parallels the one observed in substance addiction, suggesting a specific neural mechanism for food addiction that contributes to overeating and obesity. It is important to note the significant correlation between obesity and depression, indicating a shared biological pathway influencing these conditions. Stress substantially affects also eating behaviors, often leading to increased consumption of pleasurable and rewarding foods. This can trigger a cycle of overeating, weight gain, and psychological distress, exacerbating mood disorders and obesity. In addition, consumption of certain types of foods, especially “comfort foods” high in fat and calories, may provide temporary relief from symptoms of depression, but can lead to long-term obesity and further mental health problems. Understanding these complex interactions is critical to developing preventive strategies focusing on dietary, emotional, and environmental factors, thereby reducing the risk of obesity and mood disorders.

show abstract

Increased depression-like behaviors with dysfunctions in the stress axis and the reward center by free access to highly palatable food

Cited by 10 publications

References 62 publications

Mood, food, and obesity

Mood, food, and obesity

Obesogenic diets induce anxiety in rodents: A systematic review and meta‐analysis

Dietary habits, depression and obesity: an intricate relationship to explore in pediatric preventive strategies

Contact Info

Product

Resources

About