Increased dopaminergic activity in socially isolated rats: An electrophysiological study

Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: Mood-congruent memory in male mice?

“…This was particularly important in the present study because SI increased locomotion in the PM-DAT despite increasing immobility in the FST and in the TST. This increase in locomotor activity induced by SI is in line with the results of previous studies [47][48][49][50] that have linked it to both a decrease in the basal turnover of serotonin in the nucleus accumbens 48 and an increase in the activity of dopamine neurons in the mesoaccumbens system. 50 Avoidance of the aversive enclosed arm in the PM-DAT on testing has been validated as a measurement of retention because amnestic manipulations decrease it.…”

“…This increase in locomotor activity induced by SI is in line with the results of previous studies [47][48][49][50] that have linked it to both a decrease in the basal turnover of serotonin in the nucleus accumbens 48 and an increase in the activity of dopamine neurons in the mesoaccumbens system. 50 Avoidance of the aversive enclosed arm in the PM-DAT on testing has been validated as a measurement of retention because amnestic manipulations decrease it. 17,19,43,45,46,51 We examined whether the SI-induced depressive-like behaviour would facilitate the retrieval, thereby characterizing an MCM in mice.…”

Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain

“…35 and (ii) an autocorrelogram showing either an initial trough that rose smoothly to a steady state or an initial peak followed by decay to a steady state (Fig. 2E) (Fabricius et al, 2010).…”

“…As a consequence, cell firing was defined regular if it satisfied two conditions: (i) a CV <35% and (ii) an autocorrelogram showing three or more regularly occurring peaks (Fig. 2E) (Fabricius et al, 2010); whereas irregular firing patterns were those with (i) a CV ! 35 and (ii) an autocorrelogram showing either an initial trough that rose smoothly to a steady state or an initial peak followed by decay to a steady state (Fig.…”

Pharmacological characterization of social isolation-induced hyperactivity

“…Indeed, rearing rats in social isolation induces pronounced effects on behavior (for review see Fone and Porkess 2008) and brain development (Fabricius et al 2010b). In short, it has been reported that socially isolated rats display neurochemical alterations such as a hyper-responsive dopamine system, including increased responsiveness to psychomotor stimulants (Douglas et al 2003;Fabricius et al 2010a;Hall et al 1998;Jones et al 1992), and behavioral alterations such as disrupted sensory-motor gaiting shown as deficits in prepulse inhibition (PPI) (Cilia et al 2001;Cilia et al 2005;Geyer et al 1993;Powell et al 2003;Swerdlow et al 2000), impaired memory and learning (Abdul-Monim et al 2003;Bianchi et al 2006;Douglas et al 2003), as well as a consistent spontaneous hyperlocomotion to novelty . PPI deficits, especially, in SI animals have been extensively investigated for predictive validity.…”