Increased ethanol consumption after interruption of fat bingeing

Abstract

There is a marked comorbidity between alcohol abuse and eating disorders, especially in the young population. We have previously reported that bingeing on fat during adolescence increases the rewarding effects of ethanol (EtOH). The aim of the present work was to study if vulnerability to EtOH persists after cessation of binge eating. OF1 mice binged on fat (HFB: high-fat binge) during adolescence (PND 25–43) and were tested for 15 days after the last access to HFB (on PND 59) using the self-administration paradigm, the conditioned place preference (CPP) and locomotor sensitization to ethanol. Our results showed that after 15 days of cessation of fat ingestion, mice increased their consumption of ethanol and showed greater motivation to obtain ethanol. On the other hand, no effects were observed in the CPP, while an increased locomotor response to ethanol was detected. The present results confirm and extend our previous study demonstrating that the compulsive intake of fat induces long-lasting effects on the reward system that lead to an increased consumption of EtOH.

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

“…The HFDb-S group exhibited an increased alcohol consumption compared to the SD-S group. Previous experiments in our laboratory showed that ethanol consumption is increased by HFD bingeing during adolescence [ 58 , 81 ]. The repeated stimulation of the reward system during episodes of HFD bingeing influences the dopaminergic signaling [ 82 , 83 , 84 , 85 ].…”

Ketogenic Diet Decreases Alcohol Intake in Adult Male Mice

“…Motivation to seek drugs of abuse and highly palatable foods is regulated by the reward system [ 1 ]. Previous studies have shown psychological and biological commonalities between palatable food intake and drug addiction [ 2 , 3 ] and recent studies have indicated that nutritional habits are an important modulating factor in the development of cocaine [ 4 , 5 ] and alcohol addiction [ 6 , 7 ]. Palatable diets change metabolism and the reward system by increasing vulnerability to the rewarding effects of psychostimulants and depressants, such as cocaine and alcohol [ 4 , 6 , 8 ], but little is known about the protective effects that nutrition could have in the development of drug addiction.…”

Título: Dieta, drogas y cerebro. Subtítulo:¿Podría ser la comida ultraprocesada una puerta de entrada a la adicción?

“…Similarly, when we made the task required to obtain the drug more difficult (by increasing the number of required nose pokes), these animals showed more motivation to receive the drug (Blanco-Gandía et al, 2018). Not only did they consume more, but they also worked harder to get it.…”