2022
DOI: 10.1111/jre.13067
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Increased expression of angiopoietin‐like protein 4 regulates matrix metalloproteinase‐13 expression in Porphyromonas gingivalis lipopolysaccharides‐stimulated gingival fibroblasts and ligature‐induced experimental periodontitis

Abstract: Background Angiopoietin‐like protein 4 (ANGPTL4) is produced in chronic or acute inflammation. Although ANGPTL4 increases in the periodontal ligament fibroblasts during hypoxia, the involvement and role of ANGPTL4 in periodontitis have not been elucidated. Objective In this study, we investigated whether ligature‐induced experimental periodontitis and/or Porphyromonas gingivalis lipopolysaccharides (Pg‐LPS) would upregulate ANGPTL4 expression and whether ANGPTL4 would somehow involve in the expression of matri… Show more

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