Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis

CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis

“…We first compared CD40L expression on resting and activated CD4 T cells between patients with RA and healthy controls, and we confirmed previously reported significant increases in CD40L expression in RA patients (Fig. 7A, 7B) (27). Furthermore, we found a significant correlation between CD4 T cell expression of CD40L and the size of the CD32B low/neg subpopulation in CD27 + IgD 2 B cells in RA (Fig.…”

Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?

“…The latter finding may be relevant to RA, since overexpression of CD40 and CD40 ligand (CD40L) in the rheumatoid synovium (synovial fibroblasts and lymphocytes, respectively) may play a role in RA pathogenesis (111). Indeed, interruption of CD40-CD40L interaction has been identified as a potential therapeutic target in RA (112,113).…”

Clinical implications of the tumor necrosis factor family in benign and malignant hematologic disorders

“…In humans, constitutive expression of CD40L has been observed in T cells of patients having autoimmune disorders and in malignant B and T lymphocytes of patients with lymphoma or leukemia. 39,[41][42][43][44] The function of CD40 in B-cell malignancies has been examined by several groups, with conflicting results, mainly because of the use of different methods for activating CD40. Similarly, the outcome of CD40 activation has been shown to be dependent on the cell type that is examined: cell lines (mouse or human) versus primary malignant human B-cell lymphoma and leukemia.…”