Increased Expression of VEGF, COX-2, and Ki-67 in Barrett’s Esophagus: Does the Length Matter?

Zampeli, Evanthia; Karamanolis, George; Morfopoulos, George; Xirouchakis, Elias; Kalampoki, Vasiliki; Michopoulos, Spyros; Savva, Sotiria; Tzias, V.; Zouboulis-Vafiadis, Irene; Kamberoglou, Dimitrios; Ladas, Spiros D.

doi:10.1007/s10620-011-1990-6

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…COX‐2 overexpression can inhibit apoptosis and increase the proliferation and the invasiveness of cancer cells resulting in angiogenesis . Second, previous studies also found that an increased COX‐2 expression was positively associated with the development and malignant progression of Barrett's esophagus, the precursor lesion for EAC . Third, but not last, aspirin use may decrease the inflammatory complications of gastroesophageal reflux disease, the strongest risk factor for EAC .…”

Section: Discussionmentioning

confidence: 98%

“…35,36 Second, previous studies also found that an increased COX-2 expression was positively associated with the development and malignant progression of Barrett's esophagus, the precursor lesion for EAC. [37][38][39][40] Third, but not last, aspirin use may decrease the inflammatory complications of gastroesophageal reflux disease, the strongest risk factor for EAC. 41 Thus, aspirin could protect against EAC by a direct and indirect multi-step process.…”

Section: Discussionmentioning

confidence: 99%

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The non‐linear threshold association between aspirin use and esophageal adenocarcinoma: results of a dose–response meta‐analysis

Yao

Liu

et al. 2014

Pharmacoepidemiology and Drug

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

The non‐linear threshold association between aspirin use and esophageal adenocarcinoma: results of a dose–response meta‐analysis

Yao

Liu

et al. 2014

Pharmacoepidemiology and Drug

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“…[1][2][3][4][5][6]14,15 Although previous studies established a trend in the metaplasia-dysplasia-carcinoma sequence, none have clearly demonstrated whether high-grade dysplasia is significantly different from metaplasia or lowgrade dysplasia. Our study specifically demonstrates a significant and stepwise increase in microvascular density between Barrett' esophagus, low-grade dysplasia and high-grade dysplasia, which has not been previously shown.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of microvascular density in Barrett's associated neoplasia

et al. 2013

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Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. The aim of this study is to assess the correlation between microvascular density and disease progression of non-dysplastic Barrett's esophagus, low-grade dysplasia, high-grade dysplasia and invasive carcinoma in the superficial aspects of the tissue. Archival histological specimens from two referral centers for Barrett's esophagus and esophageal cancer were selected for review. A total of 160 regions marked according to histological grade were assessed with digitally interactive software to measure microvascular density. This was quantified in three levels: 0-50, 50-100 and 100-150 lm. In the areas of gastric cardia, Barrett's esophagus, low-grade dysplasia, high-grade dysplasia and cancer, microvascular density was significantly different (Po0.0001) among the five groups in the most superficial 150 lm of the mucosa. Furthermore, when examining the pairwise difference between the groups, there was a significant difference between cancer and each of the lower grades of histology (Po0.05) and between high-grade dysplasia and each of the lower grades of histology (Po0.05). These statistically significant differences were preserved in examining the depth at the most superficial 50 lm. We have used digital pathology to demonstrate a significant and stepwise increase in microvascular density, which supports the hypothesis that angiogenesis has a key role in Barrett's carcinogenesis. Furthermore, the differences in the most superficial mucosal layers are consistent with findings of increased vascularity by depth-restricted imaging modalities. Modern Pathology (2013) 26, 125-130; doi:10.1038/modpathol.2012 published online 24 August 2012 Keywords: angiogenesis; Barrett's esophagus; esophageal cancer; microvascular density Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. 1,2 Esophageal adenocarcinoma arises from Barrett's esophagus in a metaplasia-dysplasia-carcinoma sequence. Intestinal metaplasia and dysplasia have been studied in terms of microvascular density, and neoangiogenesis is thought to begin in these precursor lesions. [3][4][5][6][7]

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“…In particular, its levels have been found elevated in patients with intestinal type gastric cancer, lesion which is associated with IM. An increase in its levels has also been reported in patients with esophagitis and in patients with Barrett’s esophagus ( 35 , 36 ). Regarding the correlation of MetS with the VEGF, studies have shown that VEGF levels are related to MetS components.…”

Section: Discussionmentioning

confidence: 84%

Plasma VEGF and Leptin Values in Patients With Gastric Intestinal Metaplasia and Metabolic Syndrome

et al. 2022

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Intestinal metaplasia of the stomach (IM) is considered a pre-cancerous lesion and is a potential precursor to adenocarcinoma. Metabolic syndrome (MetS) has been associated with lesions to the gastrointestinal tract such as the risk of developing Barett esophagus. Vascular endothelial growth factor and leptin have been associated with either gastrointestinal tract carcinogenesis or MetS. In this context, this study was designed to analyze plasma levels of VEGF and leptin in patients with IM and MetS. Four groups of 137 participants (a control group and three patient groups, IM, MetS and IM- MetS) were created. Inclusion criteria for the presence of IM were endoscopic findings and histological confirmation, while for MetS the ATP III and IDF guidelines. Levels of plasma vascular endothelial growth factor (VEGF) and leptin (Leptin) were determined. VEGF levels were increased in IM (IM vs Control, p=0,011) and IM-MetS groups (IM-MetS vs Control, p <0.001 and IM-MetS vs MetS, p=0.001). Leptin levels were found to be increased in the MetS group (MetS vs. Control, p <0.001 and MetS vs IM, p <0.001) and in IM-MetS (IM-MetS vs Control, p = 0.002, IM-MetS vs IM, p=0.033). Patients with intestinal metaplasia and metabolic syndrome (I M - Me t S g r o u p) have elevated levels of VEGF, while leptin levels were associated predominantly with MetS and not with IM.

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Increased Expression of VEGF, COX-2, and Ki-67 in Barrett’s Esophagus: Does the Length Matter?

Abstract: VEGF, COX-2, and Ki-67 were overexpressed in the majority of Barrett's samples. The length was inversely associated with VEGF expression and directly associated with Ki-67 expression.

Cited by 6 publications

References 46 publications

The non‐linear threshold association between aspirin use and esophageal adenocarcinoma: results of a dose–response meta‐analysis

The non‐linear threshold association between aspirin use and esophageal adenocarcinoma: results of a dose–response meta‐analysis

Evaluation of microvascular density in Barrett's associated neoplasia

Plasma VEGF and Leptin Values in Patients With Gastric Intestinal Metaplasia and Metabolic Syndrome

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