Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma

Czifra, Gabriella; Varga, Attila; Nyeste, Katalin; Marincsák, Rita; Tóth, Balázs István; Kovács, Ilona; Kovács, László; Bı́ró, Tamás

doi:10.1007/s00432-008-0482-3

Cited by 95 publications

(70 citation statements)

References 26 publications

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“…Clinical investigation found a remarkably elevated TRPV1 expression in the epithelial cells of prostate cancer samples when compared to either the healthy or the BPH sections (Czifra et al 2009). The expression of TRPV1 increased in parallel and gradually with the Gleason grade (Czifra et al 2009).…”

Section: Trpv1 Receptormentioning

confidence: 95%

The Potential Antitumor Effects of Capsaicin

Díaz‐Laviada

Rodríguez-Henche

2014

Capsaicin as a Therapeutic Molecule

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Capsaicin, one of the major pungent ingredients found in red peppers, has been recently demonstrated to induce apoptosis in many types of malignant cell lines including colon adenocarcinoma, pancreatic cancer, hepatocellular carcinoma, prostate cancer, breast cancer, and many others. The mechanism whereby capsaicin induces apoptosis in cancer cells is not completely elucidated but involves intracellular calcium increase, reactive oxygen species generation, disruption of mitochondrial membrane transition potential, and activation of transcription factors such as NFκB and STATS. Recently, a role for the AMP-dependent kinase (AMPK) and autophagy pathways in capsaicin-triggered cell death has been proposed. In addition, capsaicin shows antitumor activity in vivo by reducing the growth of many tumors induced in mice. In this chapter, we report the last advances performed in the antitumor activity of capsaicin and review the main signaling pathways involved. CapsaicinCapsaicin (8-methyl-N-vanillyl-6-noneamide) is the major constituent of the peppers belonging to the genus Capsicum and responsible for their spicy flavor and burning sensation, also known as pungency. Besides capsaicin, a family of related compounds are present in Capsicum sp. plants, all referred as capsaicinoids. These compounds are capsaicin, dihydrocapsaicin, nordihydrocapsaicin, and homocapsaicin. Capsaicin

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Section: Trpv1 Receptormentioning

confidence: 95%

The Potential Antitumor Effects of Capsaicin

Díaz‐Laviada

Rodríguez-Henche

2014

Capsaicin as a Therapeutic Molecule

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“…In spermatozoa, anandamide activation of CB1 or TRPV1 exerts different functions, possibly in different time windows [138,139]. In several cancer cell types, both CB1/CB2 and TRPV1 expression can be increased compared to that of the corresponding non-transformed cells (see, [140] for an example], and activation of these receptors, via different molecular and cellular mechanisms, can counteract cancer growth [141] and/or reduce cancer cell invasiveness [142].…”

Section: Discussionmentioning

confidence: 99%

Why do cannabinoid receptors have more than one endogenous ligand?

Marzo

Petrocellis

2012

Phil. Trans. R. Soc. B

252

176

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The endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle, D 9-tetrahydrocannabinol, and includes two G-proteincoupled receptors (GPCRs; the cannabinoid CB1 and CB2 receptors), their endogenous ligands (the endocannabinoids, the best studied of which are anandamide and 2-arachidonoylglycerol (2-AG)), and the proteins that regulate the levels and activity of these receptors and ligands. However, other minor lipid metabolites different from, but chemically similar to, anandamide and 2-AG have also been suggested to act as endocannabinoids. Thus, unlike most other GPCRs, cannabinoid receptors appear to have more than one endogenous agonist, and it has been often wondered what could be the physiological meaning of this peculiarity. In 1999, it was proposed that anandamide might also activate other targets, and in particular the transient receptor potential of vanilloid type-1 (TRPV1) channels. Over the last decade, this interaction has been shown to occur both in peripheral tissues and brain, during both physiological and pathological conditions. TRPV1 channels can be activated also by another less abundant endocannabinoid, N-arachidonoyldopamine, but not by 2-AG, and have been proposed by some authors to act as ionotropic endocannabinoid receptors. This article will discuss the latest discoveries on this subject, and discuss, among others, how anandamide and 2-AG differential actions at TRPV1 and cannabinoid receptors contribute to making this signalling system a versatile tool available to organisms to fine-tune homeostasis.

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“…TRPV1 is activated by selective potent natural agonists such as capsaicin (CAPS) and resiniferatoxin (RTX), pungent compounds found in chili pepper and in a tropical plant called Euphorbia resinifera, respectively [13]. Upregulation of TRPV1 channels in neoplastic breast and prostate tissue compared to normal tissue has been reported before [14,15], but little is known about the channel's physiological function and the likely pathological consequences in these neoplasms. Virtually all pharmacological and molecular methods used to examine the function of these channels resulted in a decrease of cell viability.…”

Section: Introductionmentioning

confidence: 99%