Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes

Mito-TEMPO, a Mitochondria-Targeted Antioxidant, Improves Cognitive Dysfunction due to Hypoglycemia: an Association with Reduced Pericyte Loss and Blood-Brain Barrier Leakage

“…Male C57BL/6J mice (20-25 g) were purchased from Shanghai Slacker Laboratory Animal Co., Ltd (Shanghai, China) and randomly divided into normal (NC), diabetic (DM), severely (DH), and severely + Mito-TEMPO-treated (DHT) groups. DHT mice were treated with 0.7 mg/kg/d Mito-TEMPO (SML0737; Sigma-Aldrich) [10,13]. T1D was induced with a single intraperitoneal (i.p.)…”

“…On the 3rd day post-injection, mice had blood glucose levels of > 16.7 mmol/L and presented with polyuria, polydipsia, polyphagia, and wasting, suggesting successful induction of T1D. After fasting overnight, DH and DHT mice were intravenously injected with regular insulin (15 mU/g; Wanbang, Jiangsu, China) to maintain tail vein glucose levels of < 2.0 mmol/L for 90 min [10]. To terminate episodes, mice were allowed to inject glucose (1 mg/kg i.p.…”

“…Mito-TEMPO is a mitochondria-targeted antioxidant that acts in ischemic tissues [9]. Previous studies by our team have con rmed that Mito-TEMPO can attenuate severe hypoglycemia-induced cardiac damage [10]. In terms of brain damage, animal experiments have shown that Mito-TEMPO not only inhibited mitochondrial ROS production and rescued mitochondrial respiratory function but also effectively reduced the accumulation of tau oligomers in mouse cortical neurons and improved cognitive function [11].…”

A Microelectrode Array Modified by PtNPs/PB Nanocomposites Used for the Detection and Analysis of Glucose-Sensitive Neurons under Different Blood Glucose States

“…Fasting effectively induces low metabolism, with significance in long-term manned flight. , However, long-term fasting causes hypoglycemia and cardiovascular disease, damaging to the organism and leading to repeated hypoglycemia, which represents an inability to maintain blood glucose homeostasis. , Therefore, focusing on glucose homeostasis can facilitate the understanding and improvement of glucose balance control during fasting. Since an injury to the ventral medial hypothalamus (VMH) leads to hyperplasia, it is called a “satiety center”. − The VMH has a critical function in blood glucose control, which can obtain blood glucose data from the body and deliver blood glucose data to various brain regions. − Glucose-sensitive neurons affected by blood glucose were discovered in the VMH. − …”

“…1,2 However, long-term fasting causes hypoglycemia and cardiovascular disease, damaging to the organism and leading to repeated hypoglycemia, which represents an inability to maintain blood glucose homeostasis. 3,4 Therefore, focusing on glucose homeostasis can facilitate the understanding and improvement of glucose balance control during fasting. Since an injury to the ventral medial hypothalamus (VMH) leads to hyperplasia, it is called a "satiety center".…”