Increased Fibroblast Metabolic Activity of Collagen Scaffolds via the Addition of Propolis Nanoparticles

González-Masís, Jeimmy; Cubero-Sesín, Jorge M.; Corrales-Ureña, Yendry Regina; González-Camacho, Sara; Mora-Ugalde, Nohelia; Baizán-Rojas, Mónica; Loaiza, Randall; Vega-Baudrit, José; González-Paz, Rodolfo J.

doi:10.3390/ma13143118

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…They reported that despite the capillary increase in the healing tissue, they did not observe a significant difference compared to the control group. González-Masís et al[ 22 ] adsorbed propolis into scaffolds consisting of collagen extracted as nanoparticles from rat tails. They showed that propolis increased the denaturation temperature and tensile strength of collagen.…”

Section: Discussionmentioning

confidence: 99%

The effect of caffeic acid on tendon healing in rats with an Achilles tendon injury model

Yurteri,

Mercan,

Çelik

et al. 2023

Jt Dis Relat Surg

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Objectives This study aims to examine the effect of caffeic acid on tendon healing histopathologically and biomechanically in rats with an Achilles tendon injury model. Materials and methods Twenty male Wistar-albino rats were used in this study. The rats were divided into two groups as the experimental group and control group. All rats underwent a bilateral achillotomy injury model and then surgical repair. Postoperatively, for four weeks, the experimental group was given intraperitoneal caffeic acid (100 mg/kg/day suspended in saline), while the control group was given only intraperitoneal saline. At the end of four weeks, after sacrificing each rat, right Achilles tendons were subjected to biomechanical analysis and the Achilles tendons were subjected to histopathological analysis. Bonar and Movin scores were used for histopathological analysis. In biomechanical analysis, tensile test was applied to Achilles tendons until rupture. For each tendon, failure load, displacement, cross-sectional area, maximum energy, total energy, length, stiffness, ultimate stress and strain parameters were recorded. Results According to Bonar and Movin scoring, the experimental group had lower scoring values than the control group (p=0.002 and p=0.002, respectively). Bonar scoring parameters were analyzed separately. Vascularity, collagen, and ground substance scores were lower in the experimental group compared to the control group (p=0.001, p=0.003, and p=0.047, respectively). No significant difference was found for tenocyte (p=0.064). In biomechanical analysis, failure load, displacement, ultimate stress, strain, and stiffness values were found to be higher in the experimental group compared to the control group (p=0.049, p=0.005, p=0.028, p=0.021, and p=0.049, respectively). Conclusion The caffeic acid contributed positively to tendon healing histopathologically and biomechanically in rats with an Achilles tendon injury model.

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Section: Discussionmentioning

confidence: 99%

The effect of caffeic acid on tendon healing in rats with an Achilles tendon injury model

Yurteri,

Mercan,

Çelik

et al. 2023

Jt Dis Relat Surg

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“…Within its self-assembly, the properties of a collagen scaffold, in particular collagen denaturation and tensile strength, can be reduced by impregnation and following deposition on fibrils of propolis nanoparticles [ 68 ]. At 100 μg/mL, the propolis obtained from Apis mellifera maintained the fibril structure of collagen extracted from rat tail and enabled the culture of fibroblast cell line, by providing cells a metabolic stimulus, likely activating their proliferation.…”

Section: Scaffold Design and Experimental Studiesmentioning

confidence: 99%

The Potential of Honeybee Products for Biomaterial Applications

Rossi

Marrazzo

2021

Biomimetics

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The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target tissues can suffer injuring inflammation. The inclusion of nature-derived bioactive compounds usually offers a suitable strategy to expand or increase the functional properties of biomaterial scaffolds and can even promote tissue healing. Honey is traditionally known for its healing property and is a mixture of phytochemicals that have a proven reputation as antimicrobial, anti-inflammatory, and antioxidant agents. This review discusses on the potential of honey and other honeybee products for biomaterial improvements. Our study illustrates the available and most recent literature reporting the use of these natural products combined with different polymeric scaffolds, to provide original insights in wound healing and other tissue regenerative approaches.

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“…Natural polymers such as chitosan, gelatin, collagen, and cellulose have been widely used for biomedical applications as ECM due to their great biocompatibility and bioactivity. However, their main limitations are related to batch variability and unsuitable physicochemical properties for certain manufacturing processes [49][50][51][52].…”

Section: Thermo-responsive Smart Polymersmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

Self Cite

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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Increased Fibroblast Metabolic Activity of Collagen Scaffolds via the Addition of Propolis Nanoparticles

Cited by 12 publications

References 36 publications

The effect of caffeic acid on tendon healing in rats with an Achilles tendon injury model

The effect of caffeic acid on tendon healing in rats with an Achilles tendon injury model

The Potential of Honeybee Products for Biomaterial Applications

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

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