Increased Glycation of Hemoglobin in Chronic Renal Failure Patients and Its Potential Role of Oxidative Stress

Selvaraj, N.; Bobby, Zachariah; Sridhar, Magadi Gopalakrishna

doi:10.1016/j.arcmed.2008.01.001

Cited by 36 publications

(23 citation statements)

References 89 publications

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“…There are essentially three different means by which they can do this: altering [28] Glycation rate Genetics [26,70] Regular aspirin ingestion [11] a High doses of vitamins C and E [71,72] a Oxidative stress [73] Erythrocyte lifespan…”

Section: Biological Variability Of Hba 1cmentioning

confidence: 99%

“…1 Prevalence of diabetesspecific retinopathy (moderate or more severe retinopathy) by vigintiles of the distribution of FPG, 2hPG and HbA 1c from the DETECT-2 analysis (adapted with permission from [57]). Indicative of chronic glycaemia [12] Results can be misleading in certain physiological and disease states [73] More convenient, as patient not required to fast and only one blood sample taken Not a direct measure of glycaemia Validated as a risk marker for complications and mortality [15][16][17][18]98] May vary with age and between different ethnic groups [65] Less intra-individual variability [99,100] More expensive, being unaffordable in many low and middle-income country settings [4] Greater pre-analytical stability [34,101] comes more widely used the epidemiological landscape of type 2 diabetes will be altered. It remains to be determined whether or not these supposed ethnic differences in HbA 1c are clinically consequential.…”

Section: Hba 1c For Diagnosismentioning

confidence: 99%

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Current controversies in the use of haemoglobin A_1c

Hare

Shaw

Zimmet

2012

Journal of Internal Medicine

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Abstract. Hare MJL, Shaw JE, Zimmet PZ (Baker IDI Heart and Diabetes Institute, Melbourne, Vic.; and Monash University, Melbourne, Vic.; Australia). Current controversies in the use of haemoglobin A 1c (Review). J Intern Med 2012;271: 227-236.Haemoglobin A 1c (HbA 1c ) has recently been adopted by the World Health Organization into its recommended criteria for diabetes diagnosis. Much debate continues regarding the relative benefits and potential disadvantages surrounding the use of HbA 1c for this purpose. There is a lack of consensus as to whether this alteration to the definition of diabetes is a step forward or whether it could add further confusion and ambiguity to the debate on the method and criteria for the diagnosis of this globally important disease. This review provides a comprehensive overview of the current issues surrounding how HbA 1c is measured and reported; and of the evidence for and against its use in diagnosis.

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Section: Biological Variability Of Hba 1cmentioning

confidence: 99%

Section: Hba 1c For Diagnosismentioning

confidence: 99%

Current controversies in the use of haemoglobin A_1c

Hare

Shaw

Zimmet

2012

Journal of Internal Medicine

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“…8 These observations translate to patients on RRT, with alterations in glycated hemoglobin affected by erythropoietin therapy and arterial pH. 9 Other factors that artificially decrease the A 1c assay in hemodialysis patients include blood loss (during treatment or frequent blood sampling), shortened red blood cell survival, red blood cell transfusions, and erythropoietin treatment. 10 In the context of peritoneal dialysis, initiation of continuous peritoneal ambulatory dialysis coincides with an increase in levels of glycated hemoglobin perhaps as a result of confounding by dialysate absorption.…”

mentioning

confidence: 99%

Diagnostic Application of the A1c Assay in Renal Disease

Sharif¹,

Baboolal²

2010

Journal of the American Society of Nephrology

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“…HbA 1c is not an acceptable alternative to detect diabetes in ESRD. There are many confounding factors that affect the accuracy of HbA 1c measurements in ESRD [42], including shortened red blood cell survival, frequent blood loss, erythropoietin treatment, acidosis [43], and increased oxidative stress [44]. In all participants, we corroborated a medical history and medical records with fasting blood glucose measurements prior to transplantation.…”

Section: Discussionmentioning

confidence: 55%

Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus

et al. 2016

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Background/Objective: Post-transplant diabetes mellitus (PTDM) is both common and associated with poor outcomes after kidney transplantation. Our objective was to examine relationships of uremia-associated inflammation and adiponectin with PTDM. Methods: Nondiabetic kidney transplant patients were enrolled with donor controls. Inflammatory cytokines and adiponectin were measured before and after transplantation. Adipose tissue was obtained for gene expression analysis. Glucose transport was quantified in vitro in C2C12 cells following cytokine exposure. The patients were monitored up to 12 months for PTDM. Results: We studied 36 controls and 32 transplant patients, of whom 11 (35%) developed PTDM. Compared to controls, plasma TNFα, IL-6, MCP-1, and CRP levels were higher in transplant patients (p < 0.01). In multivariable analysis, TNFα plasma levels before transplantation were associated with development of PTDM (OR = 2.03, p = 0.04). Visceral adipose tissue TNFα mRNA expression was higher in transplant patients than controls (fold change 1.33; p < 0.05). TNFα mRNA expression was also higher in patients who developed PTDM than in those who did not (fold change 1.42; p = 0.05), and adiponectin mRNA expression was lower (fold change 0.48; p < 0.05). The studies on the C2C12 cells demonstrated an increase in glucose uptake following exposure to adiponectin and no significant change after exposure to TNFα alone. Concomitant TNFα and adiponectin exposure blunted adiponectin-induced glucose uptake (11% reduction; p < 0.001). Conclusion: Our in vitro and clinical observations suggest that TNFα could contribute to PTDM through an effect on adiponectin. Our study proposes that inflammation is involved in glucose regulation after kidney transplantation.

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Increased Glycation of Hemoglobin in Chronic Renal Failure Patients and Its Potential Role of Oxidative Stress

Cited by 36 publications

References 89 publications

Current controversies in the use of haemoglobin A_1c

Current controversies in the use of haemoglobin A_1c

Diagnostic Application of the A1c Assay in Renal Disease

Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus

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Increased Glycation of Hemoglobin in Chronic Renal Failure Patients and Its Potential Role of Oxidative Stress

Cited by 36 publications

References 89 publications

Current controversies in the use of haemoglobin A1c

Current controversies in the use of haemoglobin A1c

Diagnostic Application of the A1c Assay in Renal Disease

Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus

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Product

Resources

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Current controversies in the use of haemoglobin A_1c

Current controversies in the use of haemoglobin A_1c