1989
DOI: 10.3109/00365528909093108
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Increased Gut Permeability to Fluorescein Isothiocyanate-Dextran after Total Parenteral Nutrition in the Rat

Abstract: Sepsis with subsequent multiple organ failure is the commonest complication seen in the surgical intensive care unit today. A gut mucosal barrier dysfunction is assuming an increasingly important role as one possible explanation for the initiation of the septic process. It is known that the gut bacteria and endotoxins can, in the presence of a seemingly intact epithelium, translocate to extraintestinal sites, but the exact mechanism behind this process is not understood. In the present study we have approached… Show more

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Cited by 41 publications
(11 citation statements)
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“…Several investigators have documented a loss of epithelial integrity in experimental models of TPN, as well as in humans [16,17]. This increased permeability was initially demonstrated by Purandare et al by showing increased permeability with a fluorinated material [18]. More recently, this increased permeability was confirmed by Kahn et al, using tagged polystyrene latex beads [19].…”
Section: Discussionsupporting
confidence: 51%
“…Several investigators have documented a loss of epithelial integrity in experimental models of TPN, as well as in humans [16,17]. This increased permeability was initially demonstrated by Purandare et al by showing increased permeability with a fluorinated material [18]. More recently, this increased permeability was confirmed by Kahn et al, using tagged polystyrene latex beads [19].…”
Section: Discussionsupporting
confidence: 51%
“…One of the major complications in TPN-infused patients is the loss of intestinal epithelial barrier function which may cause the penetration of luminal endotoxins or bacteria into the liver, leading to parenteral nutrition-associated liver disease (PNALD) [15-18]. This study aimed to investigate the roles of p38 MAPK in intestinal barrier loss and hepatic injury based on the model of TPN.…”
Section: Introductionmentioning
confidence: 99%
“…TPN may keep gut little stress, conversely cause mucosal atrophy. Furthermore, these morphological changes induced by TPN were demonstrated to associate with reduced lymphocytes, increased gut permeability and enhanced bacterial translocation [22-26], which can increase risk of postoperative sepsis and postoperative morbidity/mortality [13, 27]. Small intestinal atrophy was shown to affect nitrogen metabolism to a greater extent than liver by-pass [28], which was also reconfirmed in our study that weight of small bowel showed positive linear relationship with levels of nitrate anabolism.…”
Section: Discussionmentioning
confidence: 99%