Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease

Sajadieh, Ahmad; Nielsen, Olav Wendelboe; Rasmussen, Verner; Hein, Hans Ole; Abedini, Sadollah; Hansen, Jørgen Fischer

doi:10.1016/j.ehj.2003.12.003

Cited by 345 publications

(299 citation statements)

References 39 publications

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“…A relation between impaired cardiac parasympathetic function and a subclinical inflammatory state has recently been reported in several clinical studies [18][19][20][21]. Such a relation implies that impairment of the autonomic modulation of inflammation, because of significant autonomic dysfunction, may favour an increase in subclinical inflammation.…”

Section: Inflammation and Cardiac Autonomic Functionmentioning

confidence: 84%

“…Similarly, a relation between ANS activity and inflammation has recently been reported in experimental studies [16][17][18] as well as in several diseases [19][20][21][22], but the exact relation between ANS activity and inflammation in the clinical setting remains unclear. In particular, how inflammatory stimuli affect sympathovagal balance in humans has not been explored.…”

Section: Introductionmentioning

confidence: 96%

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Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

Lanza

Barone

Scalone

et al. 2010

Journal of Internal Medicine

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Section: Inflammation and Cardiac Autonomic Functionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 96%

Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

Lanza

Barone

Scalone

et al. 2010

Journal of Internal Medicine

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“…27 Tachycardia or autonomic imbalance is also associated with subclinical inflammation represented by an elevated CRP and leukocyte count. 28,29 Inflammation is believed to have a central role in the pathogenesis and progression of atherosclerosis and is an important risk factor for future cardiovascular events. 30 In the experimental setting, inflammatory reaction was reduced by sympathectomy.…”

Section: Mechanismsmentioning

confidence: 99%

Effect of heart rate on the risk of developing metabolic syndrome

Inoue

Iseki

et al. 2009

Hypertens Res

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High heart rate and metabolic syndrome are risk factors for cardiovascular morbidity and mortality. The relationship between heart rate and risk of developing metabolic syndrome has not been studied in a large cohort. We examined the relationship between heart rate and the risk of developing metabolic syndrome in individuals who participated in a health evaluation program from 1997 to 2002. Among the 7958 individuals who participated in the program, 1677 were excluded from our study because they were being treated for heart disease or had been diagnosed with metabolic syndrome at baseline examination. A total of 6281 individuals (3789 men and 2492 women, 20-89 years of age) were evaluated. They were categorized according to their baseline heart rate and were followed up for a mean of 47 ± 16 months (range: 7-71 months). Over the 5-year period, 619 individuals (9.9%) developed metabolic syndrome. Men with elevated baseline heart rates were more likely to experience metabolic syndrome than were those with normal heart rates. This was not true for female patients. The odds ratio (95% confidence interval) of developing metabolic syndrome among men in the highest quartile for heart rate was 1.725 (1.282-2.320) compared with those in the lowest quartile. Each increase in the heart rate category led to an approximately 1.2-fold increase in the risk of developing metabolic syndrome for men only, even after adjusting for age and lifestyle. Elevated heart rate is a risk factor for developing metabolic syndrome in men.

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“…31,32 C-reactive protein has been associated with increased heart rate and reduced heart rate variability, two putative markers of sympatho-vagal imbalance. 33 The relationship between inflammation and case-fatality rate was significant only in subjects with normal BP. Although speculatively, this could suggest that hypertension and inflammation are related to case-fatality through the same mechanisms, and that one of them is sufficient to increase the risk.…”

Section: Discussionmentioning

confidence: 98%

Fatality of acute coronary events in relation to hypertension and low-grade inflammation: a population-based cohort study

et al. 2006

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Hypertension has been associated with increased casefatality rates among individuals who subsequently suffer from acute coronary events. It is unknown whether inflammation modifies this relationship. This population-based study explored the effects of inflammation and hypertension on incidence of coronary event, and on the fatality of the future events. Blood pressure (BP) and five inflammation-sensitive plasma proteins (ISPs, fibrinogen, orosomucoid, a1-antitrypsin, haptoglobin and ceruloplasmin) were determined in 6071 healthy men. During the mean follow-up of 19 years, 679 men had a first coronary event (non-fatal myocardial infarction or death from coronary heart disease). Of them, 197 (29%) were fatal cases (death during the first day). As expected, hypertension was associated with increased incidence of coronary events and increased proportion of fatal cases. At all levels of BP, high ISPs (X2 ISPs in top quartile) significantly added to the incidence of events. Men with high ISPs had the highest case-fatality rates. The difference in case-fatality rate between men with and without high ISPs was, however, significant only in men with normal BP (o130/85 mm Hg) (33 vs 19%, Po0.05), and not in men with moderate or severe hypertension (X160/100 mm Hg) (40 vs 35%, P ¼ 0.32). High ISPs add to the incidence of coronary events at all levels of BP. Hypertension and inflammation are both independently associated with increased case-fatality in subjects who later have an acute coronary event. The influence of ISPs on the case-fatality rate seems to be most important in men with normal BP.

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Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease

Cited by 345 publications

References 39 publications

Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

Effect of heart rate on the risk of developing metabolic syndrome

Fatality of acute coronary events in relation to hypertension and low-grade inflammation: a population-based cohort study

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