Increased hydraulic conductance of human articular cartilage and subchondral bone plate with progression of osteoarthritis

Hwang, Jennifer; Bae, Won C.; Shieu, Wendy; Lewis, Chad W.; Bugbee, William D.; Sah, Robert L.

doi:10.1002/art.24069

Cited by 110 publications

(101 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This phenomenon has also been observed in other animal models of OA [17,28]. The reduction in the thickness of the calcified cartilage layer could be attributable to a systematic process of demineralization in the activated joint [31], vascular invasion of the subchondral bone [18], or both phenomena. Changes in the mineral content and thickness of the calcified cartilage layer conceivably play a more prominent role in the pathogenesis of OA than has been hitherto supposed [6,30].…”

Section: Discussionsupporting

confidence: 63%

“…The increased stress thereby imposed on the other components of the joint complex usually triggers a process of tissue remodeling, which, by altering the loading dynamics of the joint, exacerbates rather than alleviates the disease symptoms [18,21]. Furthermore, the pain and restricted ROM associated with OA necessitate changes in the pattern of loading by the affected individual, which further complicate the development of the disease.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stereologic Analysis of Tibial-Plateau Cartilage and Femoral Cancellous Bone in Guinea Pigs With Spontaneous Osteoarthritis

Wang

Arsenault

Hunziker

2011

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background Two strains of guinea pig develop spontaneous osteoarthritis of the knee. Although the disease evolves at different rates in the two strains, it is not known whether these differences are reflected in the structure of the cartilage and cancellous bone. Questions/purposes We determined whether the threedimensional structure of the tibial-plateau cartilage and femoral cancellous bone differed between the two strains. Methods Six Dunkin-Hartley and six GOHI/SPF guinea pigs were evaluated. The animals were sacrificed at 11 months of age. The 24 proximal tibias were used for a stereologic histomorphometric analysis of the tibial-plateau cartilage. The 24 femurs were used for a site-specific, three-dimensional quantitative analysis of the cancellous bone by micro-CT. Results Compared to the GOHI/SPF guinea pigs, the tibial-plateau cartilage of the Dunkin-Hartley strain had a larger lesion volume (3.8% versus 1.5%) and a thicker uncalcified cartilage layer (0.042 versus 0.035 mm), but a thinner calcified cartilage zone (0.008 versus 0.01 mm) and a thinner subchondral cortical bone plate (0.035 versus 0.039 mm). The femoral cancellous bone in the DunkinHartley strain had a lower bone mineral density (477 versus 509 mg/cm 3 ). However, the trabeculae were thicker (3.91 versus 3.53 pixels) and farther apart (7.8 versus 5.6 pixels). The osteoarthritic changes in the cartilage were topographically mirrored in the subchondral bone. They were most severe on the medial side of the joint, particularly in the anterior region. Conclusions Spontaneous osteoarthritis in the guinea pig is associated with site-specific changes in the articular cartilage layer, which are topographically mirrored in the underlying subchondral bone. Clinical Relevance Three-dimensional structural information not revealed by two-dimensional radiography may help characterize the stages of osteoarthritis.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Stereologic Analysis of Tibial-Plateau Cartilage and Femoral Cancellous Bone in Guinea Pigs With Spontaneous Osteoarthritis

Wang

Arsenault

Hunziker

2011

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…Indeed, the ability of cartilage to support load through interstitial fluid pressurization is dependent on its low hydraulic permeability, which is nothing else that the ease of fluid flow through a material. For articular cartilage it is governed by the extracellular matrix and increases in the middle and deep zone with osteoarthritis (Hwang et al, 2008;Setton et al, 1994). Therefore, low heat transfer is expected via fluid-movement for normal healthy cartilage, while it may increase with tissue degeneration, sustaining our hypothesis that temperature increases in healthy cartilage but not in degenerated one.…”

Section: Discussionmentioning

confidence: 54%

“…However, only little fluid exudation occurs in the middle and deep layers of articular cartilage (Hwang et al, 2008;Maroudas and Bullough, 1968;Stockwell and Barnett, 1964). Indeed, the ability of cartilage to support load through interstitial fluid pressurization is dependent on its low hydraulic permeability, which is nothing else that the ease of fluid flow through a material.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Abdel-Sayed

Moghadam

Salomir

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Temperature Magnetic resonance imagingDifferential scanning calorimetry a b s t r a c t Metabolism of proteoglycans and hyaluronic acid has been shown to be temperaturedependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in this study that viscoelastic properties of healthy human cartilage allow its temperature to reach those optimal temperatures during physiological mechanical loadings. We developed a model allowing to determine the temperature increase in cartilage due to viscous dissipation. The model had three parameters, which were determined experimentally. The first parameter was the energy dissipated by cartilage samples submitted to cyclic stimulation. It was obtained with standard in vitro mechanical testing. The second parameter was the cartilage heat capacity and was measured in vitro with differential scanning calorimetry. Finally, the third parameter was the time constant of cartilage heat transfer and was obtained with in vivo magnetic resonance thermometry performed on four volunteers. With these experimentally determined parameters, the model predicted that cartilage dissipation is sufficient to raise the temperature in healthy knee cartilage from 33 1C to 36.7 1C after a 1 h walking. These results showed that intrinsic viscoelastic properties of the cartilage could induce a temperature increase optimal for the production of proteoglycans and hyaluronic acid. Interestingly, degenerated cartilage did not present high enough viscoelastic properties to significantly induce a temperature increase. Taken together, these data suggest an association between cartilage dissipation and its homeostasis.

show abstract

“…CC was removed by using surgical methods ( 9,25,26 ). In addition, both UCC and CC are lost in osteoarthritis in regions of eburnation ( 6 ).…”

Section: Ute Mr Imagingmentioning

confidence: 99%

Ultrashort Echo Time MR Imaging of Osteochondral Junction of the Knee at 3 T: Identification of Anatomic Structures Contributing to Signal Intensity

Bae¹,

Dwek²,

Znamirowski³

et al. 2010

Radiology

Self Cite

102

View full text Add to dashboard Cite

Purpose:To image cartilage-bone interfaces in naturally occurring and experimentally prepared human cartilage-bone specimens at 3 T by using ultrashort echo time (TE) (UTE) and conventional pulse sequences to (a) determine the appearance of the signal intensity patterns and (b) identify the structures contributing to signal intensity on the UTE MR images. Materials and Methods:This study was exempted by the institutional review board, and informed consent was not required. Five cadaveric (mean age, 86 years 6 4) patellae were imaged by using proton density-weighted fat-suppressed (repetition time msec/TE msec, 2300/34), T1-weighted (700/10), and UTE (300/0.008, 6.6, with or without dual-inversion preparations at inversion time 1 = 135 msec and inversion time 2 = 95 msec) sequences. The UTE images were compared with proton density-weighted fat-suppressed and T1-weighted images and were evaluated by two radiologists. Results:On the UTE MR images, all patellar sections exhibited a high-intensity linear signal near the osteochondral junction, which was not visible on protein density-weighted fat-suppressed or T1-weighted images. In some sections, focal regions of thickened or diminished signal intensity were also found. In the prepared samples, UCC only, CC/bone, and UCC/CC/bone samples exhibited high signal intensity on the UTE images, whereas bone-only samples did not. Conclusion:These results show that the high signal intensity on UTE images of human articular joints originates from the CC and the deepest layer of the UCC, without a defi nite contribution from subchondral bone. UTE sequences may provide a way of evaluating abnormalities at or near the osteochondral junction.q RSNA, 2010

show abstract

Increased hydraulic conductance of human articular cartilage and subchondral bone plate with progression of osteoarthritis

Cited by 110 publications

References 39 publications

Stereologic Analysis of Tibial-Plateau Cartilage and Femoral Cancellous Bone in Guinea Pigs With Spontaneous Osteoarthritis

Stereologic Analysis of Tibial-Plateau Cartilage and Femoral Cancellous Bone in Guinea Pigs With Spontaneous Osteoarthritis

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Ultrashort Echo Time MR Imaging of Osteochondral Junction of the Knee at 3 T: Identification of Anatomic Structures Contributing to Signal Intensity

Contact Info

Product

Resources

About