Increased Incidence of Invasive Fusariosis with Cutaneous Portal of Entry, Brazil

Nucci, Márcio; Varon, Andréa G.; Garnica, Márcia; Akiti, Tiyomi; Barreiros, Glória; Trope, Beatriz Moritz; Nouér, Simone Aranha

doi:10.3201/eid1910.120847

Cited by 94 publications

(63 citation statements)

References 22 publications

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“…Unlike infections in the normal host, fusariosis in the immunocompromised population is typically invasive and disseminated. Disseminated infections occur mainly in patients with hematological malignancies and have also occasionally been reported in the immunocompromised patients due to transplantation, solid tumors, and autoimmune disorders [13,[27][28][29][30]. In line with this, 80 % of the patients with disseminated fusariosis in the present study had hematological malignancy.…”

Section: Discussionsupporting

confidence: 76%

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Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Cilo

Al‐Hatmi

Seyedmousavi

et al. 2015

Eur J Clin Microbiol Infect Dis

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Fusarium species have started appearing increasingly as the main cause of infections, particularly in immunocompromised patients. In this study, we aimed to present the first epidemiological data from Turkey, analyze fusariosis cases that have been monitored in a university hospital during the past 20 years, identify the responsible Fusarium species, and determine antifungal susceptibilities. A total of 47 cases of fusariosis was included in the study. Fusarium isolates were identified by multilocus sequence typing (MLST). Antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology. Of the Fusarium infections, 23.4 % were superficial, 44.7 % were locally invasive, and 31.9 % were disseminated. A significant increase was observed over the years. The Fusarium fujikuroi species complex (FFSC) proved to be the most frequent agent group (17 cases; 51.5 %), followed by the Fusarium solani species complex (FSSC) (14 cases; 42.4 %), the Fusarium dimerum species complex (FDSC), and the Fusarium oxysporum species complexes (FOSC) (one case each). Amphotericin B had the highest in vitro activity against all species. Voriconazole and posaconazole showed interspecies variability across and within Fusarium species complexes. In conclusion, our data support the fact that regional differences exist in the distribution of the Fusarium species and that species-specific differences are observed in antifungal susceptibility patterns. The monitoring of local epidemiological data by determining fungal identity and susceptibility are of importance in guiding the clinical followup of patients.Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 76%

“…These are the first epidemiological data on fusarioses from Turkey. Similar to recent surveys elsewhere, a statistically significant increase in the incidence of fusarioses over the years was also determined in this study [26,27].…”

Section: Discussionsupporting

confidence: 73%

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Cilo

Al‐Hatmi

Seyedmousavi

et al. 2015

Eur J Clin Microbiol Infect Dis

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“…Infection occurs mainly through inhalation of airborne conidia or via breaks in the skin due to trauma and/or burns (Muhammed et al, 2011). Twelve species were associated with infection; Fusarium solani was the most frequent (∼50% of cases), followed by Fusarium oxysporum (∼20%) and Fusarium verticillioidis and Fusarium moniliforme (∼10% each) (Nucci et al, 2013).…”

Section: Life-threatening Fungal Infectionsmentioning

confidence: 99%

Mycoses and Antifungals: reviewing the basis of a current problem that still is a biotechnological target for marine products

et al. 2014

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Currently, the limited number of antifungals available for treating fungal infections, the increased multiresistance, and the adverse effects are the major obstacles for fungal infection therapy. Additionally, the recent emergence of opportunistic fungus infections reinforced the requirement for discovering novel antifungal agents. Herein we reviewed the main topics about fungi and its related infections, the antifungals available, their mechanism of action and resistance profile. In this work, we pointed fungi as a biotechnological target for finding new options in alternative sources such as marine products with new mechanisms of action to allow treating these dangerous infections.

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“…These localized or locally invasive forms may herald disseminated disease. 6 Fusarium is a plant pathogen and opportunistic human pathogenic mould. It has been commonly described in patients with hematological malignancies and hematopoietic stem cell transplant recipients, especially with neutropenia.…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous hyalohyphomycosis caused byFusariumin a kidney transplant recipient

et al. 2014

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Fusarium is a filamentous opportunistic pathogenic fungus responsible for superficial as well as invasive infection in immunocompromized hosts. Net state of immunosuppression and cytomegalovirus (CMV) infection appear to predispose to this disease which is life-threatening when disseminated. Though infections with Fusarium have been widely described in hematological malignancies and hematopoietic stem cell transplant cases, they have been reported to be rare in solid organ transplant recipients, are often localized and carry a favorable prognosis. We here describe a rare case of subcutaneous non-invasive infection with Fusarium in a renal allograft recipient two and half years after transplantation. Patient had a previous history of CMV infection along with multiple other recurrent co-infections. Diagnosis was based on culture of tissue specimens yielding Fusarium species. The infection had a protracted course with persistence of lesions after treatment with voriconazole alone, requiring a combination of complete surgical excision and therapy with the anti-fungal drug.

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Increased Incidence of Invasive Fusariosis with Cutaneous Portal of Entry, Brazil

Abstract: Most cases of infection with Fusarium spp. fungi involved primary skin lesions.

Cited by 94 publications

References 22 publications

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Mycoses and Antifungals: reviewing the basis of a current problem that still is a biotechnological target for marine products

Subcutaneous hyalohyphomycosis caused byFusariumin a kidney transplant recipient

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