Increased Incidence of Type I Diabetes in Children of Older Mothers

Flood, Thomas M.; Brink, Stuart; Gleason, Ray E.

doi:10.2337/diacare.5.6.571

Cited by 30 publications

(24 citation statements)

References 4 publications

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“…The finding of increased risk with maternal age confirms observations from other studies [13][14][15][16][17][18] and is therefore likely to represent a real association. Social class groupings according to mothers' occupations at the time of interview, therefore post-diagnosis, were not dissimilar for cases and control subjects but there was a notable excess of case mothers unclassified because they were not in paid employment.…”

Section: Discussionsupporting

confidence: 81%

“…[Diabetologia (1997) 40: 933-939] childhood IDDM [12]. Other maternal factors such as maternal-child blood group incompatibility [13], older age of mothers [13][14][15][16][17], toxaemia [13], maternal diabetes [13,15] and mother's educational attainment [14,15,18] appear to influence risk. Caesarean delivery [13,15], birthweight [19,20] and birth order [15,16] have also been implicated, although the mechanisms are unclear.…”

mentioning

confidence: 99%

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Antenatal risk factors for childhood diabetes mellitus; a case-control study of medical record data in Yorkshire, UK

et al. 1997

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

Antenatal risk factors for childhood diabetes mellitus; a case-control study of medical record data in Yorkshire, UK

et al. 1997

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“…Several studies reported that older maternal age is a risk factor for T1D in the offspring [Flood et al, 1982;Wagener et al, 1983;Warram et al, 1991]. Since birth order correlates highly with maternal age, it is possible that increasing birth order is also a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Preferential transmission of type 1 diabetes from parents to offspring: fact or artifact?

Guo

Tuomilehto

2002

Genetic Epidemiology

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It has been widely reported that men with type 1 diabetes (T1D) tend to be more likely to transmit the disease to their offspring than their female counterparts in Caucasoid populations. Several theories to explain this preferential transmission have been proposed, but so far none of them has been unequivocally proven. Whatever the mechanism, confirmation or refutation of this observation is nonetheless important and practical to the design of future genetic studies of T1D. We carried out some statistical modeling of the preferential transmission. The well-established fact that males have higher a prevalence of T1D than females, an apparent sex difference in fecundity, and a possible misclassification of gestational diabetes mellitus (GDM) as T1D in women have been considered. We demonstrated, first, that the ascertainment of study families through the affected offspring with T1D would generate a higher proportion of fathers than mothers having T1D, even though there was no preferential transmission at all. This can be explained by the male preponderance in T1D prevalence as compared with females, coupled with a greater likelihood of being selected and/or recruited for study in families with T1D fathers due to the fecundity difference. Second, when the study population is ascertained through affected parents, misclassification of mothers with GDM as T1D, and the existence of male/female difference in

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“…Maternal age at delivery and birth order Studies of varying design relating maternal age and birth order to type 1 diabetes were carried out between the 1960s and 1990s [64][65][66][67]. The pooled analysis of newer studies showed heterogeneity in the strength of the association, but most suggested increased risk among the offspring of mothers who were older when they gave birth [57].…”

Section: Parturitionmentioning

confidence: 99%