Increased interleukin‐18 in gingival crevicular fluid from periodontitis patients

Figueredo, Carlos Marcelo; Rescala, Bruno; Teles, Ricardo; Teles, Flavia; Fischer, Ricardo Guimarães; Haffajee, A. D.; Socransky, S. S.; Gustafsson, Anders

doi:10.1111/j.1399-302x.2007.00408.x

Cited by 45 publications

(46 citation statements)

References 16 publications

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“…Recently, our research group demonstrated that IL-18 in the gingival crevicular fluid (GCF) is higher in periodontitis patients and is associated with periodontopathogens from the red complex (11). Therefore, it is reasonable to believe that IL-18 might be involved in periodontal destruction and progression, making it interesting the analysis of the local effect of periodontal treatment.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

Campos

Fischer

Gustafsson³

et al. 2012

Braz. Dent. J.

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The aim of this study was to evaluate the effectiveness of the non-surgical periodontal treatment in reducing the gingival crevicular fluid (GCF) levels of IL-18 from inflamed periodontal sites. Fourteen patients with periodontal disease were included, being 9 patients with chronic periodontitis (mean age: 48.8 SD ± 7.4 years) and 5 patients with gingivitis (mean age: 43.6 SD ± 11.8). The patients were divided in the following groups: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). Probing pocket depth (PPD), probing attachment level (AL), plaque index (PI) and gingival index (GI) were recorded, and gingival fluid samples were collected. The subjects received non-surgical treatment and were re-evaluated 30 days after treatment (day 30 AT). There was a significant reduction in PI in GG (1.0 ± 0.4 to 0.5 ± 0.2), GP (1.2 ± 0.3 to 0.5 ± 0.3), and in PP (1.3 ± 0.4 to 0.7 ± 0.3) 30 AT. There was also a significant reduction in the GI in GG (1.3 ± 0.3 to 0.7 ± 0.4). PPD reduced significantly in GG (2.4 ± 0.6 to 1.9 ± 0.1), and PP (6.7 ± 1.1 to 5.2 ± 0.9) 30 AT. When all the samples were analyzed together, there was a significant reduction in IL-18 (12.9 ± 7.2 to 10.0 ± 3.1). This study showed that non-surgical treatment was effective in reducing GCF levels of IL-18 from inflamed periodontal sites.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

Campos

Fischer

Gustafsson³

et al. 2012

Braz. Dent. J.

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“…Unstimulated saliva and GCF samples were collected as previously described (Figueredo et al, 2008;Gursoy et al, 2010). Saliva samples were centrifuged at 20,000 x g for 10 min, and the resulting supernatants were kept frozen at -80°C.…”

Section: Saliva and Gcf Samplesmentioning

confidence: 99%

Expression and Possible Immune-regulatory Function of Ghrelin in Oral Epithelium

et al. 2011

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Originally found in stomach mucosa, ghrelin is a peptide appetite hormone that has been implicated as an immuno-modulatory factor. Ghrelin has also been found in salivary glands and saliva; however, its expression patterns and biological properties in the oral cavity remain unclear. Therefore, we investigated the expression patterns of ghrelin in saliva, gingival crevicular fluid (GCF), and gingival tissue, as well as its in vitro effects on IL-8 production by TNF-α or LPS-stimulated oral epithelial cells. In the clinical samples obtained from 12 healthy volunteers, the concentration of ghrelin in GCF remarkably exceeded that detected in saliva. The expression of ghrelin mRNAs and growth hormone secretagogue (GHS) receptors could be detected in human oral epithelial cells. Immunohistochemical analysis revealed the expression of ghrelin in gingival epithelium, as well as in fibroblasts in the lamina propria. Ghrelin increased intracellular calcium mobilization and cAMP levels in oral epithelial cells, suggesting that ghrelin acts on epithelial cells to induce cell signaling. Furthermore, synthetic ghrelin inhibited the production of IL-8 from TNF-α or LPS-stimulated oral epithelial cells. These results indicate that ghrelin produced in the oral cavity appears to play a regulatory role in innate immune responses to inflammatory infection.

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“…In the presence of IL-12, IL-18 mainly persuades the manufacture of interferon-gamma-producing Th1 cells, and in absenteeism of IL-12, it shifts the response to IL-4 manufacturing Th2 cells. [8][9][10] Hence, IL-18 appears to be a latent factor that can play a key role in amendable the immune responses intricate in the initiation and advancement of periodontal disease. In a study conducted by Figueredo et al, it has been evidenced that IL-1b might play a role as a factor between gingivitis in periodontitis patients and gingivitis in otherwise healthy patients.…”

Section: Discussionmentioning

confidence: 99%

“…Interleukin-18 is primarily formed by oral epithelial cells, osteoblasts, adrenal cortex cells, and antigen-presenting cells. 7,8 Interleukin-18 is found to be upregulated in various chronic inflammatory diseases, including periodontal disease 9,10 and has a significant role in advancement of periodontal disease because of its chemotactic, proinflammatory action. This cytokine also surges the rates of neutrophil stimulation.…”

Section: 5005/jp-journals-10024-2180mentioning

confidence: 99%

Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population

Mahajani¹,

Jadhao

Wankhade³

et al. 2017

The Journal of Contemporary Dental Practice

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Aim:The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health. Materials and methods:Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis.Results: Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in

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Increased interleukin‐18 in gingival crevicular fluid from periodontitis patients

Cited by 45 publications

References 16 publications

Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

Expression and Possible Immune-regulatory Function of Ghrelin in Oral Epithelium

Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population

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