Increased iron levels and lipid peroxidation in a Mediterranean population of Spain

Aranda, Núria; Fernández‐Cao, José C.; Tous, Mònica; Arija, Victoria

doi:10.1111/eci.12625

Cited by 15 publications

(14 citation statements)

References 42 publications

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“…4a and b ). Elevated serum levels of iron not only may trigger free radical-mediated processes, but also activate immune system and induce inflammation as a form of an early protective response [ 35 ]. Available evidence suggests that some constituents of cranberry fruits may act as immunostimulants, mitigating the inflammation [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers

Skarpańska-Stejnborn¹,

Basta

Trzeciak³

et al. 2017

Journal of the International Society of Sports Nutrition

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BackgroundThe aim of this study was to analyze the effect of supplementation with cranberry (Vaccinum macrocarpon) on the levels of pro-inflammatory cytokines, hepcidin and selected markers of iron metabolism in rowers subjected to exhaustive exercise.MethodsThis double-blind study included 16 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group (n = 9), receiving 1200 mg of cranberry extract for 6 weeks, or to the placebo group (n = 7). The participants performed a 2000-m test on a rowing ergometer at the beginning and at the end of the preparatory camp. Blood samples were obtained from the antecubital vein prior to each exercise test, one minute after completing the test, and after a 24-h recovery period. The levels of hepcidin, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), ferritin, iron, soluble transferrin receptor (sTfR) and myoglobin were determined, along with total iron-binding capacity (TIBC), unbound iron-binding capacity (UIBC) and total antioxidant capacity (TAC).ResultsBoth prior and after the supplementation, a significant post-exercise increase in the concentration of IL-6 was observed in both groups. At the end of the study period, cranberry-supplemented athletes presented with significantly higher resting, post-exercise and post-recovery levels of TAC than the controls. However, a significant exercise-induced increase in the concentrations of TNF-alpha, myoglobin and hepcidin was observed solely in the control group.ConclusionSupplementation with cranberry extract contributed to a significant strengthening of antioxidant potential in individuals exposed to strenuous physical exercise. However, supplementation did not exert direct effects on other analyzed parameters: inflammatory markers and indices of iron metabolism (TNF-alpha, hepcidin and myoglobin).

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Section: Discussionmentioning

confidence: 99%

Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers

Skarpańska-Stejnborn¹,

Basta

Trzeciak³

et al. 2017

Journal of the International Society of Sports Nutrition

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“…Serum ferritin is also recognized as an acute phase marker of inflammation. Some studies have explored whether elevated serum ferritin levels are associated with low-grade inflammation [32, 33], such as in chronic kidney disease [34], rheumatoid arthritis [35] and other autoimmune disorders [36]. These diseases exhibit low-grade inflammation and are mediated by oxidative stress, which is characterized by an imbalance between the generation of reactive oxygen species (ROS) and responses from the antioxidant defense system[37].…”

Section: Discussionmentioning

confidence: 99%

Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Jiang

Bao²,

Zhang

et al. 2017

PLoS ONE

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ObjectiveSeveral studies have indicated that elevated levels of circulating ferritin are associated with disturbances in energy metabolism. But none of this gave a clearly pathologic mechanism. We aimed to explore the independent relationship between serum ferritin levels and dyslipidemia.MethodsWe performed multivariable logistic regression analyses to estimate the odds ratios (ORs) for dyslipidemia, lipid parameters, the homeostasis model assessment of insulin resistance (HOMA-IR) and the risk of diabetes, according to sex-specific quartiles of serum ferritin by using the data of China Health and Nutrition Survey (2009 CHNS). We used three models to estimate the strength of the correlation. The basic model (Model 1) is without adjustment and the Model 2 and Model 3 are adjusted for demographic, anthropometric, and lifestyle confounding factors.ResultsIn both genders, the ORs for high TG level, TC level and LDL-C level increased progressively and for HDL-C decreased across the ferritin quartiles (P<0.001 for trend). After adjustment for confounding factors in different logistic regression models, the results remained unchanged. The ORs for the risk of diabetes and high HOMA-IR level in the highest quartile group of serum ferritin levels were significantly increased in Model 1, but after adjustment for lipid parameters, the ORs for the risk of diabetes was decreased from 1.91 (95% CI: 1.37–2.67; P<0.001 for trend) to 1.48 (95% CI: 1.03–2.12; P = 0.036 for trend) in men, and from 5.40 (95% CI: 3.38–8.63; P<0.001 for trend) to 1.43 (95% CI: 0.83–2.43; P = 0.498 for trend) in women, and the ORs for IR was decreased from 1.86 (95% CI: 1.57–2.20; P<0.001 for trend) to 1.25 (95% CI: 1.05–1.50; P = 0.114 for trend) in men, and from 1.93 (95% CI: 1.63–2.28; P<0.001 for trend) to 1.24 (95% CI: 1.01–1.51; P = 0.012 for trend) in women.ConclusionOur results provide evidence that serum ferritin levels are significantly associated with lipid parameters, independent of glucose metabolism disorders and components of metabolic syndrome (MetS). Thus, serum ferritin plays a key role in energy metabolism disorders and may affect glucose metabolism through lipid metabolism.

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“…In this regard, it has been observed that blood donors [32] and subjects undergoing phlebotomy [33] are more likely to prevent T2DM because of the corresponding decrease in B-IronS. It is speculated that oxidative stress [34,35] is the mechanism by which excess iron is associated with a higher incidence of T2DM. On the contrary, reduced B-IronS may entail a lower degree of oxidative stress, which in turn may decrease risk of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Soluble transferrin receptor and risk of type 2 diabetes in the obese and nonobese

Fernández‐Cao

Arija

Aranda

et al. 2017

Eur J Clin Investigation

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Increased iron levels and lipid peroxidation in a Mediterranean population of Spain

Abstract: In our general population, we have observed that higher circulating levels of iron, measured by serum ferritin and/or TS, increased lipid peroxidation (measured by oxLDL/LDL ratio).

Cited by 15 publications

References 42 publications

Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers

Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers

Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Soluble transferrin receptor and risk of type 2 diabetes in the obese and nonobese

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