Soluble transferrin receptor and risk of type 2 diabetes in the obese and nonobese

Fernández‐Cao, José C.; Arija, Victoria; Aranda, Núria; Basora, Josep; Díez‐Espino, Javier; Estruch, Ramón; Fitó, Montse; Corella, Dolores; Salas‐Salvadó, Jordi

doi:10.1111/eci.12725

Cited by 18 publications

(18 citation statements)

References 38 publications

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“…However, our finding of the positive association between sTfR and CKD is consistent with Alam et al, who observed high sTRF levels in patients with CKD than those without CKD (27). This association can also be comparable with previous observations that increased level of sTfR had adverse effects on different health outcomes, including diabetes or insulin resistance (15,32), iron-deficiency anemia (33), and obesity (34). In this study, we also found a U-shaped relationship of Hb and CKD, which is comparable with findings from other health outcomes, such as mortality (35), birth outcome (36), and stroke severity (14).…”

Section: Discussionsupporting

confidence: 92%

“…Serum ferritin (SF), soluble transferrin receptor (sTfR), hemoglobin (Hb), and transferrin are the most widely used clinical biomarkers of iron. Previous publications have reported the relationships between these markers with hypertension (12), hyperuricemia (13), stroke (14), and diabetes (15). However, there are limited studies evaluating whether iron levels are associated with estimated glomerular filtration rate (eGFR)/CKD in general population.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Zhu

Liu

et al. 2020

Front. Med.

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Background: Even though it is well-known that iron deficiency is the result of chronic kidney disease (CKD), whether iron will affect kidney function and disease in the general population is not clear. We thus conducted a nationwide cross-sectional study using data from the China Health and Nutrition Survey (CHNS) to assess the relationship of iron status with estimated glomerular filtration rate (eGFR) and CKD among general adults. Methods: A total of 8,339 adults from the China Health and Nutrition Survey in the wave of 2009 were included to assess the association between iron status and eGFR/CKD. Serum ferritin (SF), transferrin, soluble transferrin receptor (sTfR), and hemoglobin (Hb) were measured. The relationship of iron status and eGFR was evaluated by using multi-variable linear regression model. The effect of iron status on the odds of CKD was calculated by logistic regression model. Results: For the association between iron status and eGFR, every 100 µg/L increase in SF was correlated with 0.26 ml/min per 1.73 m² (95% CI: 0.08-0.44) decrease in eGFR, and every 5 mg/L increase in sTfR was associated with a decrease of 6.00 ml/min per 1.73 m² (95% CI: 3.79-8.21) in eGFR. There were no significant associations between Hb or transferrin with eGFR. For the association between iron status and CKD, every 5 g/L increase in sTfR was associated with an odds ratio of 3.72 (95% CI: 2.16-6.13) for CKD. The concentrations of Hb were associated with the odds of CKD in a U-shaped manner, with the lowest risk in the Hb range of 136-141 g/L. There was a positive correlation between SF concentration and CKD prevalence but not in a dose-response manner. The odds of CKD for participants in the highest tertile increased by 28% (98% CI: 1-63%) compared with those in the lowest tertile. Conclusion: The concentration of SF and sTfR was positively correlated with the odds of CKD, and Hb was associated with the odds of CKD in a U-shaped manner. Further large prospective researches are warranted to confirm these findings.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Zhu

Liu

et al. 2020

Front. Med.

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“…Of these studies, 145 were from PubMed and 23 from Embase; 23 repeated studies were excluded. After skimming the titles and abstracts, followed by an intensive reading of the full text, 12 case–control studies and cohort studies were obtained, which included 6,516 patients with type 2 diabetes and 43,120 control individuals without type 2 diabetes. The details of the screening process are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

Liu

Yang

et al. 2020

J of Diabetes Invest

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Aims/Introduction: Iron metabolism can directly or indirectly affect the occurrence and development of type 2 diabetes. This meta-analysis and systematic review aimed to analyze the association between serum iron metabolism indicators and type 2 diabetes. Materials and Methods: The databases PubMed and Embase were searched for studies on the correlations between serum iron metabolism indicators (iron, ferritin, transferrin, hepcidin and soluble transferrin receptor) and type 2 diabetes since January 2006. Relevant data were extracted from the included studies, and meta-analysis was carried out. Results: A total of 12 case-control and cohort studies were analyzed. Of the 12 studies, 11 described the correlation between serum ferritin levels and type 2 diabetes. The median and high serum ferritin concentrations were significantly associated with the risks of type 2 diabetes (odds ratio [OR] 1.20, 95% confidence interval [CI] 1.08-1.33 and OR 1.43, 95% CI 1.29-1.59, respectively). However, the low concentration was not correlated with the risk of type 2 diabetes (OR 0.99, 95% CI 0.89-1.11). No significant association was observed between serum soluble transferrin receptor and type 2 diabetes, whereas the soluble transferrin receptor-to-ferritin ratio was significantly inversely related to the risk of type 2 diabetes in the median and high ratio subgroups (OR 0.71, 95% CI 0.51, 0.99 and OR 0.65, 95% CI 0.45-0.95). Conclusions: The elevated serum ferritin was one of the risk factors for type 2 diabetes, and soluble transferrin receptor-to-ferritin ratio was inversely related to the risk of type 2 diabetes. A systematic review showed that serum transferrin and hepcidin might be directly or indirectly related to the development of diabetes.

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“…Thus, more than 80% to 90% of T2DM patients are obese. [ 22 ] The excess body weight influences almost every aspect of life and it is difficult to treat the overweight in T2DM patients. Therefore, weight management is of great significance to patients with obese T2DM.…”

Section: Discussionmentioning

confidence: 99%

The effect of care intervention for obese patients with type II diabetes

Jiang

Fan²,

Wu³

et al. 2017

Medicine

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The incidence of type II diabetes mellitus (T2DM) is increasing worldwide and affecting the quality of people's life. This study was designed to evaluate the effect of care intervention on body weight and glycemic parameters in obese T2DM patients.One hundred twenty-six obese T2DM cases were randomly divided into 2 groups. Patients in control group received conventional care, while patients in the intervention group received dietary, exercise, and psychology interventions on the basis of conventional care. Twelve months follow-up was performed to compare the changes of body weight and glycemic parameters in the 2 groups.There were 119 patients completing the research, 60 in the intervention group and 59 in control group. The levels of fasting plasma glucose (FPG), 2 hours postprandial blood glucose (PBG2 h), hemoglobin A1c (HbA1c), and aldose reductase (AR) were all significantly decreased (all, P < .05) in intervention group compared with the control group after 12 months follow-up. Moreover, the body weight and BMI (body mass index) were also significantly reduced in intervention group, and the weight loss was significantly higher in intervention group than that in control group during the follow-up.To implement care intervention for obese T2DM patients could strengthen the management of blood glucose, reduce body weight and complications.

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Soluble transferrin receptor and risk of type 2 diabetes in the obese and nonobese

Cited by 18 publications

References 38 publications

Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

The effect of care intervention for obese patients with type II diabetes

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