Increased level of serum Homocysteine in vitiligo

Abstract

An increased serum Hcy may be a precipitating factor for vitiligo in the predisposed individuals. Serum Hcy is related to the gender of patients, activity of disease, and dietary habits of vitiligo patients.

A Case Control Study: Evaluation of Serum Vitamin D Levels and Vitamin B12 Levels in Vitiligo

“…This finding coincided with the findings of Singh S et al 20 There was no statistically significant association between the duration of disease and Vitamin D3 deficiency (p value 0.532). [Table 4] Measurement of serum levels of vitamin D3 and B12 at the time of diagnosis of vitiligo is recommended and their supplementation is suggested to those suffering from the deficiencies of the same.…”

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

“…In clinical studies, recent evidence demonstrated that the level of total Hcy (tHcy) was significantly elevated in patients with vitiligo, and was more obvious in those patients in the active stage of vitiligo. 2,[17][18][19] The abnormal Hcy level was found to be significantly associated with distribution and bilaterality of lesions in vitiligo. [17][18][19] Additionally, depigmentation of the skin and hair was observed in patients with homocystinuria, which was described as 'pigmentary dilution'.…”

“…It has been reported that Hcy with abnormal metabolism and quantity or function is associated with many diseases, including vitiligo. In clinical studies, recent evidence demonstrated that the level of total Hcy (tHcy) was significantly elevated in patients with vitiligo, and was more obvious in those patients in the active stage of vitiligo . The abnormal Hcy level was found to be significantly associated with distribution and bilaterality of lesions in vitiligo .…”

“…1 Although various hypotheses have been proposed, the aetiology of vitiligo is not clear. [2][3][4][5][6] Recently, accumulating studies have suggested that oxidative stress caused by reactive oxygen species (ROS) may be the triggering event in the melanocyte impairment seen in vitiligo. [7][8][9][10][11][12][13] An increase in ROS has been found in the epidermis of patients with vitiligo, and it plays a key role in the onset and progression of melanocyte damage.…”

Stability in vitiligo: Is there a perfect way to predict it?

“…Singh et al .,[23] studied homocysteine (Hcy) levels in serum of active and stable vitiligo patients and controls. They found that there was a significant relationship between Hcy level and activity of vitiligo.…”