Increased levels of albumin in bronchial washing fluid of patients with bronchial carcinoma. Could albumin be considered as a tumor marker?

Charokopos, Nikolaos; Leotsinidis, Michalis; Tsiamita, Maria; Kalofonos, H. P.; Vasillakos, P.; Christofidou, Myrto; Spiropoulos, Kostas

doi:10.5301/jbm.2008.5643

Cited by 1 publication

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“…Therefore, we propose that the interstitial entry of large plasma proteins, such as factor H, reflects an increase in microvascular permeability of the tumor circulation. In agreement with these results, Charokopos et al (20) showed that bronchial washings from patients with lung carcinoma present an increased concentration of albumin. The authors found that the determination of albumin in bronchial washings had a high sensitivity and specificity for the diagnosis of lung cancer and suggested that the presence of albumin in the bronchial fluid was caused by its exudation to the bronchial lumen.…”

Section: Discussionsupporting

confidence: 75%

Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer

Pı́o

Blas

Corrales

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use of molecular biomarkers may enhance the sensitivity of cytologic examination in the detection of lung cancer.Methods: Complement factor H, a protein secreted by lung cancer cells, was quantified in a series of bronchoalveolar lavage supernatants from lung cancer patients and patients with nonmalignant respiratory diseases. Albumin, total protein content, and hemoglobin were also analyzed. Results were validated in independent sets of bronchoalveolar lavage and sputum supernatants.Results: There was a significantly higher concentration of factor H in bronchoalveolar lavage samples from lung cancer patients. The sensitivity and specificity of the factor H test was 82% and 77%, respectively. These results were validated in an independent set of patients with nearly identical results. Furthermore, 70% and 45% of bronchoalveolar lavage fluids from central and peripheral tumors, respectively, reported as cytologically negative, were classified as positive using this marker. Finally, the test was evaluated in a series of sputum supernatants from lung cancer patients and controls. The sensitivity and specificity of the factor H test in this series was 80% and 88%, respectively.Conclusion: Factor H is elevated in bronchoalveolar lavage and sputum from lung cancer patients. Impact: Measurement of molecular biomarkers, such as complement factor H, may be used in the future as an adjunct to cytology in the diagnosis of malignant pulmonary diseases. Cancer Epidemiol Biomarkers Prev;

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Section: Discussionsupporting

confidence: 75%

Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer

Pı́o

Blas

Corrales

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

Increased levels of albumin in bronchial washing fluid of patients with bronchial carcinoma. Could albumin be considered as a tumor marker?

Abstract: Measurement of albumin levels in BWF could be a useful additional diagnostic tool to differentiate malignant from non-malignant lung diseases. Moreover, the combined measurement of CEA in serum and albumin in BWF could be of aid in the follow-up of lung cancer patients.

Cited by 1 publication

References 16 publications

Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer

Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer

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