Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD)

Shim, Se-Hoon; Hwangbo, Young; Kwon, Young Joon; Jeong, Hee Yeon; Lee, Bun Hee; Lee, Heon Jeong; Kim, Yong Ku

doi:10.1016/j.pnpbp.2008.08.005

Cited by 113 publications

(97 citation statements)

References 41 publications

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“…In addition to this classic function as a neurotrophin during development, numerous studies have shown that low serum and/or plasma BDNF levels are associated with major depressive disorders [2,3], antidepressant drug treatment [2,3], schizophrenia [4], Alzheimer's disease [5], and attention deficit-hyperactivity disorder [6]. In addition, recent studies have reported that BDNF may be found not only in patients with psychiatric disorders but also in normal patients, as measured by physical activity [7], mental stress [8], and obesity [9].…”

Section: Introductionmentioning

confidence: 99%

Preanalysis Storage Conditions Influence the Measurement of Brain-Derived Neurotrophic Factor Levels in Peripheral Blood

et al. 2014

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Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a pivotal role in regulating neuronal function throughout life, and this factor is regarded as a potential biomarker of mental disorders. However, previous studies have suggested that plasma BDNF levels are more variable than serum BDNF levels. Methods: We determined the influence of time and temperature on the measurement of peripheral blood BDNF levels. Blood samples were aliquoted into four types of tubes, including tubes containing heparin, ethylenediaminetetraacetic acid (EDTA), and citrate for plasma, and anticoagulant-free tubes for serum. The samples were stored at 4 or 25°C for 0, 1, 2, 4, 6, 24 or 48 h, and the plasma and serum BDNF levels were measured using enzyme-linked immunosorbent assay. Results: There were interindividual and interanticoagulant compound variability in the plasma BDNF levels. The measured plasma BDNF levels increased over time, whereas the serum BDNF levels remained unchanged. Furthermore, the BDNF levels detected in plasma stored in heparin tubes at 4°C and those for samples stored in EDTA tubes at 25°C were much higher than those of the other samples. Conclusion: This study indicates that measurements of plasma BDNF levels are dependent not only on the anticoagulant compounds but also on the storage time and temperature conditions used after blood sampling.

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Section: Introductionmentioning

confidence: 99%

Preanalysis Storage Conditions Influence the Measurement of Brain-Derived Neurotrophic Factor Levels in Peripheral Blood

et al. 2014

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“…Concerning peripheral levels, higher plasma concentrations were observed in ADHD patients as compared with controls [58], whereas no alterations were observed in serum levels [60].…”

Section: Genomics/metabolomicsmentioning

confidence: 78%

Biomarkers in the Diagnosis of ADHD – Promising Directions

Faraone

Bonvicini

Scassellati

2014

Curr Psychiatry Rep

112

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The etiology and pathogenesis of attention-deficit/hyperactivity disorder (ADHD) are unclear and a more valid diagnosis would certainly be welcomed. Starting from the literature, we built an hypothetical pyramid representing a putative set of biomarkers where, at the top, variants in DAT1 and DRD4 genes are the best candidates for their associations to neuropsychological tasks, activation in specific brain areas, methylphenidate response and gene expression levels. Interesting data come from the noradrenergic system (norepinephrine transporter, norepinephrine, 3-methoxy-4-hydroxyphenylglycol, monoamine oxidase, neuropeptide Y) for their altered peripheral levels, their association with neuropsychological tasks, symptomatology, drugs effect and brain function. Other minor putative genetic biomarkers could be dopamine beta hydroxylase and catechol-O-methyltransferase. In the bottom, we placed endophenotype biomarkers. A more deep integration of "omics" sciences along with more accurate clinical profiles and new high-throughput computational methods will allow us to identify a better list of biomarkers useful for diagnosis and therapies.

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“…It has been hypothesized that BDNF is involved in the pathogenesis of ADHD, although the study results are controversial. An increase in plasma BDNF levels was found in untreated ADHD patients, and the plasma BDNF levels had a significant positive correlation with the severity of inattention symptoms [29]. However, BDNF serum levels were significantly lower in adults with ADHD compared to healthy controls (p<0.0001) [30], whereas there was no alteration of serum BDNF levels in untreated patients with ADHD [31].…”

Section: Differential Expression Of Lncrnas and Targeted Mrnas Of Bdnmentioning

confidence: 87%

Differential Expression of Long Noncoding RNAs And Targeted MRNAs in Peripheral Blood Lymphocytes of Neurodevelopmental Disorders

Xu¹,

Zhao²,

Wang³

et al. 2017

J Neuroinfect Dis

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Deregulation of long noncoding RNAs (lncRNAs) is becoming recognized as a major feature of many neurological disorders. In the current study, we aimed to measure the expression of seven lncRNAs and lncRNA-targeted mRNAs in the peripheral lymphocytes of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID) patients via quantitative real-time reverse transcriptase PCR (qRT-PCR). We found that in ADHD, the expression of mRNAs of the BDNF, SHANK2, HOXB5, and HOXA6 genes was downregulated significantly, but there was no difference in the expression of selected lncRNAs. As for ASD, the expression of the mRNAs of the HOXA6 and HOXA13 genes was significantly down-regulated, accompanied by a significant reduction of lncRNA that overlaps with the gene locus of HOXA13. A gender-dependent difference in expression of lncRNAs and targeted mRNAs was indicated in ID. In male ID, there was a significantly downregulated expression of mRNAs of HOXB5 and HOXA13, accompanied by differentially decreased expression of lncRNA-targeted mRNAs of SYT15, PKNOX2, SHANK2, HOXB5, HOXA6, and HOXA13. In female ID, the mRNAs of HOXB5 and HOXA6 were significantly down-regulated, with the significantly down-regulated expression of lncRNA-targeted mRNAs of BDNF, PKNOX2, HOXB5, and HOXA6, and the differentially increased expression of lncRNAs that overlap SYT15 and SHANK2. Our results indicated a differential expression pattern for lncRNAs and targeted mRNAs in the peripheral lymphocytes in different neurological disorders.

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Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD)

Cited by 113 publications

References 41 publications

Preanalysis Storage Conditions Influence the Measurement of Brain-Derived Neurotrophic Factor Levels in Peripheral Blood

Preanalysis Storage Conditions Influence the Measurement of Brain-Derived Neurotrophic Factor Levels in Peripheral Blood

Biomarkers in the Diagnosis of ADHD – Promising Directions

Differential Expression of Long Noncoding RNAs And Targeted MRNAs in Peripheral Blood Lymphocytes of Neurodevelopmental Disorders

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