Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis

Spiekermann, Christoph; Russo, Antonella; Stenner, Markus; Rudack, Claudia; Roth, Johannes; Vogl, Thomas

doi:10.1155/2017/9126560

Cited by 12 publications

(19 citation statements)

References 47 publications

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“…By addition of one point for each symptom like trismus, halitosis, uvula edema, unilateral swelling of the arched palate, and one point for S100A8/A9 levels over the cut-off value of 8180 ng/ml in saliva and over the cut-off value of 2550 ng/ml in serum, a PTA score value for the patients was calculated as described earlier [ 9 ]. The PTA score value ( S PTA ) ranges from a minimum of 0 to a maximum of 6.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we could identify the complex S100A8/A9 to be a helpful objective marker to identify patients with PTA and to differentiate between PTA and PC [ 9 ]. S100A8 and S100A9, which are also known as myeloid related proteins (MRP) 8 and MRP14 or calprotectin, are related to the danger-associated molecular patterns (DAMP) and show typically proinflammatory activities in many mouse models of inflammation [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…By addition of one point for each symptom like trismus, halitosis, uvula edema, unilateral swelling of the arched palate, and one point for S100A8/A9 levels in the sera or in saliva over the cut-off values (2550 ng/ml, 8180 ng/ml, resp. ), a PTA score with a range from a lowest value of 0 to a highest of 6 was developed to identify patients with PTA [ 9 ]. Hence, it was the aim of this retrospective study to analyze the new developed PTA score and its value to identify patients with peritonsillar inflammation profiting from medical treatment.…”

Section: Introductionmentioning

confidence: 99%

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Potential of the Novel PTA Score to Identify Patients with Peritonsillar Inflammation Profiting from Medical Treatment

et al. 2018

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Peritonsillar inflammation is a common characteristic of both peritonsillar abscess (PTA) and peritonsillitis (PC). The aim of the present study was to apply the PTA score as an objective criterion to identify patients with peritonsillar inflammation (PI) who might profit from medical treatment. Hence, the recently developed PTA score was applied retrospectively on patients suffering from acute tonsillitis, peritonsillitis, and peritonsillar abscess. Analysis of the clinical data, the follow-up, and the initial PTA score was performed. Patients with peritonsillar inflammation show significant higher PTA score values compared to patients with acute tonsillitis without peritonsillar inflammation and healthy controls. Patients with a PTA score ≤ 2 profited from medical treatment consisting of antibiotics in 92.3% of the cases. In 89.2% of the patients with a PTA score > 2, pus was detected during abscess relief. Patients with peritonsillar inflammation who profited from medical treatment had significantly reduced PTA score values and a reduced duration of hospitalization compared to the patients with abscess relief. Thus, the PTA score has the potential as an objective criterion to identify patients with peritonsillar inflammation profiting from medical treatment. Hence, application of the PTA score helps to determine an optimal, individualized treatment approach and might reduce utilization of medical resources.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential of the Novel PTA Score to Identify Patients with Peritonsillar Inflammation Profiting from Medical Treatment

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“…S100A8/A9 is a general indicator of inflammatory activity. Inflammation in the oral cavity, including a peritonsillar abscess, can directly affect the level of salivary S100A8/A9 (Spiekermann et al, ). Saliva reflects plasma proteins in concentration of ~3% (Edger, ).…”

Section: Discussionmentioning

confidence: 99%

Ability of S100 proteins and matrix metalloproteinase‐9 to identify periodontitis in a ligature‐induced periodontitis dog model

Liu

Lee

Jung

et al. 2019

J Clinic Periodontology

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Aims:The present study aimed to monitor the levels of selected salivary biomarkers during the development and treatment of periodontitis and to evaluate their ability to identify periodontitis in dogs. Materials and methods:A total of 15 beagle dogs were divided into a control group (no ligature), group 1 (ligature on six teeth), and group 2 (ligature on 12 teeth). The experimental periods consisted of 8 weeks of periodontitis induction and 4 weeks of treatment. Clinical measurements and the sampling of saliva were performed every 4 weeks. The levels of S100A8, S100A9, S100A8/A9, and matrix metalloproteinase (MMP)-9 were measured by enzyme-linked immunosorbent assay.Results: All experimental animals and two control animals developed periodontitis, which was successfully treated. All salivary biomarkers were significantly increased in periodontitis with high diagnostic power (c-index ≥ 0.944) and were able to identify animals with periodontitis on a single tooth. Whereas the levels of salivary S100A8/ A9 recovered to levels in health, those of S100A8, S100A9, and MMP-9 in periodontitis stability remained significantly higher than in health.Conclusion: Salivary S100A8, S100A9, S100A8/A9, and MMP-9 may be used for the screening of periodontitis in dogs, but with caution of other conditions that can affect their levels in saliva. K E Y W O R D Sbiomarkers, matrix metalloproteinase-9, periodontitis, saliva | 183 LIU et aL.

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“…Recently, we could observe increased calprotectin levels in saliva and serum of patients suffering from peritonsillar abscess (PTA) 14 . The PTA is a common but also grave infection as it can cause life-threatening complications 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the QUANTUM BLUE sCAL rapid test as a point of care tool to identify patients with peritonsillar abscess

Stahl

Roth

Rudack

et al. 2021

Sci Rep

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S100A8/A9 (Calprotectin) serves as a biomarker for various inflammatory diseases, such as for peritonsillar abscess (PTA). Recently, the PTA score was developed for reliable PTA identification. It uses a combination of characteristic clinical symptoms and elevated calprotectin levels in serum and saliva to determine this score. Although well-established point-of-care tests (POCT) to determine serum or faecal calprotectin levels exist, a reliable and rapid tool to analyse salivary calprotectin has not yet been described. In this study, we analysed the potential of the QUANTUM BLUE sCAL Test (QBT, BÜHLMANN Laboratories AG, Switzerland) to determine S100A8/A9 levels during outpatient management. These QBT measurements are combined with other clinical factors to determine the PTA score. Significantly higher calprotectin levels were determined by QBT in patients with PTA compared to healthy controls. The receiver operating characteristic (ROC) curves for the QBT revealed cut-off values of 2940 ng/ml (sensitivity = 0.88, specificity = 0.78) in serum and 5310 ng/ml (sensitivity = 0.80, specificity = 0.50) in saliva. By adding the QBT results to determine PTA values, a ROC analysis provided a statistical cut-off score of 2.5 points to identify the existence of a PTA with a sensitivity of 100% and a specificity of 89.3%. The QUANTUM BLUE sCAL Test (QBT) is an appropriate POCT to determine serum and salivary calprotectin levels. Thus, PTA scores can be determined within a short time frame by applying the QBT during outpatient management.

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Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis

Cited by 12 publications

References 47 publications

Potential of the Novel PTA Score to Identify Patients with Peritonsillar Inflammation Profiting from Medical Treatment

Potential of the Novel PTA Score to Identify Patients with Peritonsillar Inflammation Profiting from Medical Treatment

Ability of S100 proteins and matrix metalloproteinase‐9 to identify periodontitis in a ligature‐induced periodontitis dog model

Evaluation of the QUANTUM BLUE sCAL rapid test as a point of care tool to identify patients with peritonsillar abscess

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