Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes

Gonzales, Gustavo F.; Tapia, Vilma

doi:10.1515/jbcpp-2013-0162

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…GGT is a cell surface enzyme that hydrolyzes the γ-glutamyl bond of extracellular reduced and oxidized GSH into glutamate, cysteine (Cys), and glycine (Gly) ( 62 ). In line with the heightened GGT level at high altitudes ( 35 ), we found that GGT levels were much higher in Tibetans than in Hans. Moreover, higher GGT levels were reported in the group with impaired fasting glucose than in those with normal fasting glucose in the Chinese population ( 63 ), and GGT level was increased to a greater extent by high UA in Hans than in Tibetans ( Figure 3I ), indicating increased cleavage of GSH in Hans other than Tibetans.…”

Section: Discussionsupporting

confidence: 79%

“…When we compared the incidence of hyperuricemia between native Tibetans and immigrant Hans at the three altitudes in the Tibetan region, we found a similarly high prevalence of hyperuricemia between the two ethnicities but with distinct biochemical mechanisms. Hyperuricemia is closely associated with obesity and metabolic disturbances such as insulin resistance, dyslipidemia, hypertension, and kidney disease in lowlanders ( 34 ) and highlanders in Tibet ( 1 ) and Peru ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

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Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China

Ren,

Chen,

et al. 2023

Front. Endocrinol.

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PurposeWe sought to identify distinct risk factors for hyperuricemia in native Tibetan and immigrant Han populations in Tibet, China.MethodsThree cohorts of male participants aged between 20 and 40 years were enrolled in this study. Biochemical parameters including serum uric acid (UA), fasting plasma glucose, insulin, lactate dehydrogenase (LDH), thyroxin, blood cell count, aminotransferase, and lipid profiles were analyzed. The association of risk factors with UA levels was evaluated using a multivariable line regression model. The effect of UA level on the biochemical parameters between the Hans and Tibetans was evaluated by two-way ANOVA.ResultsThe prevalence of hyperuricemia (≥420 μmol/L) was 24.8% (62/250) in the Hans, similar to 23.8% (29/136) in the Tibetans. In the regression analysis, the risk factors that were significantly associated with UA in Hans did not apply to Tibetans. Tibetans had higher fasting insulin (P<0.05) and LDH (P<0.01) levels, in contrast with lower levels of triglycerides (P<0.05), total cholesterol (P<0.01), and low-density lipoprotein-cholesterol (P<0.01) than Hans in normal UA populations. Biochemistry analysis revealed lower albumin levels (P<0.001) and higher levels of all aminotransaminase and especially alkaline phosphatase (P<0.01) in Tibetans than in Hans in both populations. Compared with Hans, Tibetans had lower serum levels of urea, creatinine, and electrolytes in the normal UA population, which were further exacerbated in the high UA population. Tibetans had comparable white blood cell counts as Hans in both normal and high UA populations. In contrast, the red blood cell count and hemoglobin concentration were much lower in Tibetans than in Hans under high UA conditions.ConclusionsThe distinctive biochemistry between Tibetans and Hans may underlie the different etiologies of hyperuricemia in Tibet, China.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China

Ren,

Chen,

et al. 2023

Front. Endocrinol.

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“…The abnormal adaptation response to high altitude can cause physio-pathological changes of varying organs and tissues. Specifically, it was reported that high altitude could induce irreversible/reversible damage to high oxygen and energy demanding tissues, such as the brain, heart, liver, gastrointestinal tract, and ocular tissue, over a certain period of time (15)(16)(17)(18)(19)(20). The clinical characteristics commonly include blood pressure fluctuation, loss of memory function (declined cognitive function), absence of equilibrium function, headache, indigestion, decreased appetite, and so on (21)(22)(23)(24).…”

Section: High-altitude Heart Diseasesmentioning

confidence: 99%

The role of post-translational modifications in driving abnormal cardiovascular complications at high altitude

Hou

Wen²,

Long

et al. 2022

Front. Cardiovasc. Med.

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The high-altitude environment is characterized by hypobaric hypoxia, low temperatures, low humidity, and high radiation, which is a natural challenge for lowland residents entering. Previous studies have confirmed the acute and chronic effects of high altitude on the cardiovascular systems of lowlanders. Abnormal cardiovascular complications, including pulmonary edema, cardiac hypertrophy and pulmonary arterial hypertension were commonly explored. Effective evaluation of cardiovascular adaptive response in high altitude can provide a basis for early warning, prevention, diagnosis, and treatment of altitude diseases. At present, post-translational modifications (PTMs) of proteins are a key step to regulate their biological functions and dynamic interactions with other molecules. This process is regulated by countless enzymes called “writer, reader, and eraser,” and the performance is precisely controlled. Mutations and abnormal expression of these enzymes or their substrates have been implicated in the pathogenesis of cardiovascular diseases associated with high altitude. Although PTMs play an important regulatory role in key processes such as oxidative stress, apoptosis, proliferation, and hypoxia response, little attention has been paid to abnormal cardiovascular response at high altitude. Here, we reviewed the roles of PTMs in driving abnormal cardiovascular complications at high altitude.

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Association of serum uric acid levels with SYNTAX score II and long term mortality in the patients with stable angina pectoris who undergo percutaneous coronary interventions due to multivessel and/or unprotected left main disease

Karabağ

Rencüzoğulları

Çağdaş

et al. 2018

Int J Cardiovasc Imaging

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Serum uric acid (SUA) level was shown in various studies to be related to the presence of coronary artery disease and subsequent cardiovascular events. The aim of the present study was to evaluate the association of SUA with SYNTAX score II (SSII) and the long-term prognosis of patients with stable angina pectoris who underwent percutaneous revascularization due to multivessel disease (MVD) and/or unprotected left main disease (UPLMD). Two-hundred and ninety patients with MVD and/or UPLMD who were treated consecutively with percutaneous coronary intervention (PCI) were included in the present study. The study population was divided into high SSII (n: 145; SSII > 32.9) and low SSII (n: 145; SSII ≤ 32.9) according to the median SSII value. The SUA value was significantly higher in the high SSII group than in the low SSII group (5.53 ± 1.95 vs. 6.07 ± 1.88; p = 0.001) and was found to be an independent predictor of high SSII (OR 1.306; 95% CI 1.119-1.525; p = 0,001). Twenty-eight patients (9.7%) died during the long-term follow-up, and SUA and SSII were additionally found to be independent predictors of long-term mortality (HR 1.245, 95% CI 1.046-1.482, p = 0.014; HR 1.042, 95% CI 1.007-1.079, p = 0.018, respectively). In the present study, SUA level was demonstrated to be associated with high SSII and long-term mortality in patients with MVD and/or UPLMD who were treated with PCI.

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Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes

Abstract: At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease.

Cited by 5 publications

References 35 publications

Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China

Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China

The role of post-translational modifications in driving abnormal cardiovascular complications at high altitude

Association of serum uric acid levels with SYNTAX score II and long term mortality in the patients with stable angina pectoris who undergo percutaneous coronary interventions due to multivessel and/or unprotected left main disease

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