Increased liver stiffness and activated hepatic stellate cells in acute liver failure

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

“…An additional example of the HA importance in measuring fibrosis is the study of patients diagnosed with liver failure. The HA level correlates with liver stiffness in a sample of 29 patients with liver failure (p=0.002) (116). Therapies of HCC, using normal dose but not small dose transcatheter arterial chemoembolization led to increases in HA, PIIINP, collagen type-IV and TGF-β1 levels in a small sample of 36 HCC patients who underwent super-selective transcatheter arterial chemoembolization (117).…”