Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis

Abstract

The mean platelet volume (MPV) is a laboratory marker associated with platelet function and activity. Increased MPV in thromboembolic disease is considered an important risk factor. The aim of this study was to compare the MPV and MPV/platelet count (MPV/P) ratio between deep vein thrombosis (DVT) and control subjects. We retrospectively reviewed the medical records of patients (n = 91) admitted due to newly diagnosed DVT from December 2010 to March 2012. The control group (n = 311) underwent health screening at our Hospital. Median MPV was higher in DVT patients compared to controls (8.6 fl vs. 7.9 fl, p < 0.0001). The DVT patients also had a higher MPV/P ratio compared to the control group (0.0388 fl/(10(9)/l) vs. 0.0308 fl/(10(9)/l), p < 0.0001). MPV was inversely correlated with platelet count in DVT patients (correlation coefficient = -0.33, p = 0.001). Receiver operator characteristic analysis revealed that an MPV cutoff value of 8.2 fl provided 70.3% sensitivity and 72.7% specificity. An MPV/P cutoff value of 0.0363 fl/(10(9)/l) showed 60% sensitivity and 73% specificity. MPV and MPV/P ratio could be considered meaningful laboratory markers for the risk of DVT.

Mean platelet volume in acute appendicitis: A gender difference

“…To the editor, Mean platelet volume (MPV) is an index of platelet production and activation which reflects the changes in platelet size in various conditions [1][2][3][4][5][6][7][8]. Although, MPV is an easily obtainable index from automated hematology analyzers, it has rather been overlooked until its associations with various diseases are continuously being reported recently.…”

Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome

“…Mean platelet volume/PC ratio has been shown to be higher in thromboembolic diseases such as deep vein thrombosis and infective endocarditis. [14,15] Azab et al [13] has shown that long-term infarctioncaused mortality rate is significantly higher in patient groups with very high (40 and more) and very low (30 and less) MPV/PC ratios compared to moderately higher patient group (MPV/PC ratios of 30-40). The authors mentioned that very high MPV/PC rates resulted from extremely high MPV levels (along with elevated platelet aggregation and activation) as well as from significant decreases in platelet number.…”

“…Higher MPV/PC ratio is associated with myocardial infarction, anemia, deep vein thrombosis, infective endocarditis and hepatocellular carcinoma. [13][14][15][16] There are limited studies pointing to the association between adenoid hypertrophy and MPV in pediatric OSAS. [10,17] However, to our knowledge, there is no study in the literature dealing with the association between pediatric OSAS and MPV/PC.…”

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

“…15 An increased level of MPV was found to be related to various pathological conditions, including cardiovascular and cerebrovascular disorders, and deep venous thrombosis. [46][47][48] MPV was also investigated in some studies related to otolaryngological pathologies. Poorey et al reported an increased level of MPV due to chronic nasal obstruction in patients with deviated nasal septum.…”