Increased Mean Platelet Volume in Familial Hypercholesterolemia

Icli, Atilla; Aksoy, Fatih; Nar, Gökay; Kaymaz, Hacı; Alpay, Mehmet Fatih; Nar, Rukiye; Güçlü, Aydın; Arslan, Akif; Doğan, Abdullah

doi:10.1177/0003319715579781

Cited by 30 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous study showed that MPV is increased in patients with FH and that is independently associated with total cholesterol level [25]. platelet cholesterol (PC) can be correlated with serum LDL-C Here we could not find any differences between MPV in FH and control, the different control groups can explain our different results as in the previous study the control was the norm lipid population, however in both studies the platelet count was significantly difference between groups.…”

Section: Discussioncontrasting

confidence: 69%

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Vaseghi

Heshmat-Ghahdarijani

Shafiee

et al. 2020

Preprint

View full text Add to dashboard Cite

Background and aims:Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder of lipid metabolism which leads to premature cardiovascular diseases. In patients with FH, blood inflammatory markers may be disrupted; however, its extent is unclear. In this study we aimed to evaluate, the NLR: Neutrophil to lymphocyte ratio, PLR: Platelet count to lymphocyte count ratio, MPV: Mean platelet volume, RPR: Red blood cell distribution width to platelet count ratio, WBC: White blood cell, PDW: Platelet distribution width and platelets count. Methods:The study group consisted of 331 patients with FH and 260 control patients. Controls had a history of hyperlipidemia and both groups could be on pharmacotherapy or not. Results:None of the CBC inflammatory markers were not significantly difference in patients with FH than non-FH. Platelet count was significantly higher among patients with FH when compared to control patients (240.43±54.15 vs 228.52±47.37 p= 0.049*). When we used linear regression analysis, only RLR was independently associated with total cholesterol (b=0.000, p=0.13). Here we showed that CBC markers are nor different between FH and non-FH patients, however PLR is associated with cholesterol level not FH. Conclusions:Our results may show the important of high cholesterol on platelets activity and highlight the use of lipid lowering drugs in patients with hyperlipidemia.

show abstract

Section: Discussioncontrasting

confidence: 69%

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Vaseghi

Heshmat-Ghahdarijani

Shafiee

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The MPV is an important platelet indicator and as a marker of platelet size and activation. High MPV value is explained by a biologic explanation that larger platelets are more active in metabolic and enzymatic manner and tend to aggregate, resulting in thrombus or endothelial dysfunction than smaller platelets, as more and more research has been found that MPV is associated with prehypertension and hypertension (Varol et al ., ), type 2 diabetes (Chen et al ., ), familial hypercholesterolemia (Icli et al ., ), cancers (Kemal et al ., ; Kumagai et al ., ; Li et al ., ; Yu et al ., ), and many vascular diseases. Briefly, many studies have found that MPV associate with many vascular complications by means of endothelial damage and thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Zhang¹,

Liang

et al. 2019

Andrology

View full text Add to dashboard Cite

Background: The correlation between the increased mean platelet volume and varicocele is controversial. Objectives: We designed this research to demonstrate the correlation relationship between varicocele and mean platelet volume by studying the changes of mean platelet volume in patients with varicocele before and after operation. Materials and methods: A total of 317 patients with left unilateral varicocele underwent operation, and 293 healthy adult males were enrolled in the study. We collected diagnostic data for preoperative patients through physical examination, color Doppler ultrasonography, and blood routine, and recorded the follow-up data at 6 months after operation for varicocele. Platelet indices and the degree of varicocele or the diameter of spermatic vein correlation analysis were performed. Mean platelet volume values of preoperative and 6-month postoperative were statistically evaluated. Results: We found that the degree of varicocele and the diameter of spermatic vein were positively correlated with mean platelet volume (p = 0.001 or p < 0.001). When the left unilateral varicocele patients and healthy subjects were compared, there was a significant increase in mean platelet volume (p = 0.003). Mean platelet volume values of 96 varicocele patients who were cured by operation for varicocele after 6 months were decreased significantly more than preoperative (p = 0.039), but 32 varicocele patients of 6month postoperative recurrence could not prove this change (p = 0.930). Discussion and conclusion: Our research proves that mean platelet volume was positively correlated with the degree of varicocele and the diameter of spermatic vein and varicocele patients showed significantly higher mean platelet volume than healthy subjects. The mean platelet volume of varicocele patients cured by operation for varicocele after 6 months was lower than before, but there was no difference in mean platelet volume between 6-month postoperative recurrent patients with preoperative.

show abstract

“…We have shown that MPV was independently associated with total cholesterol level. In their study, Icli et al have shown that MPV was increased in patients with familial hypercholesterolemia and that it was independently associated with total cholesterol level [28]. As is known, increased total cholesterol levels increase the risk of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 92%

Mean Platelet Volume in Hyperthyroid Toxic Adenoma Patients after Radioactive ¹³¹I Treatment

Şimşek

Timur

Çarlıoğlu

et al. 2015

Advances in Endocrinology

View full text Add to dashboard Cite

This study demonstrates that mean platelet volume (MPV) levels decrease after radioiodine (RAI) ablation therapy in hyperthyroid patients. Regarding the fact that large platelets are hemostatically more active, we suggest that hyperthyroid patients are at risk of cardiovascular disease despite all other cardiovascular risk factors. After RAI ablation therapy as MPV levels return to normal, cardiovascular risk for hyperthyroid patients reduces.

show abstract

Increased Mean Platelet Volume in Familial Hypercholesterolemia

Cited by 30 publications

References 34 publications

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Mean Platelet Volume in Hyperthyroid Toxic Adenoma Patients after Radioactive ¹³¹I Treatment

Contact Info

Product

Resources

About

Increased Mean Platelet Volume in Familial Hypercholesterolemia

Cited by 30 publications

References 34 publications

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Mean Platelet Volume in Hyperthyroid Toxic Adenoma Patients after Radioactive 131I Treatment

Contact Info

Product

Resources

About

Mean Platelet Volume in Hyperthyroid Toxic Adenoma Patients after Radioactive ¹³¹I Treatment