“…In many psychological disorders, including depression and schizophrenia, a large cohort of patients, but not all ( 46 , 47 ), display consistent biological findings ( 48 , 49 ), namely an increase in inflammation and hyperactivity of the HPA, which drives hypercortisolemia, with consequences for the GRα pool in peripheral tissues ( 50 ). Whilst it must be noted that vast heterogeneity in GRα expression exists in patients with psychological conditions ( 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ), the current review focuses on conditions/disorders which have been explicitly linked to reductions in the GRα pool ( Table 1 ). Specifically, a number of studies have demonstrated a reduction in the GRα mRNA pool in patients suffering from major depression (MD) ( 52 , 53 , 58 ), schizophrenia ( 58 ), bipolar disorder ( 58 ) and post-traumatic stress disorder ( 54 , 56 , 57 , 59 ) in various tissues of the brain (e.g.…”