2017
DOI: 10.1016/j.jpsychires.2017.01.019
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Increased methylation of glucocorticoid receptor gene promoter 1 F in peripheral blood of patients with generalized anxiety disorder

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Cited by 40 publications
(36 citation statements)
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“…In this review, we describe a new hypothesized factor in this intergenerational transmission process: epigenetics – molecular processes that change the expression of genes independent of changing DNA sequence. Epigenetic marks have been observed in genes thought to impact stress response (Edelman et al., ; de Rooij et al., ), emotion regulation (Puglia, Lillard, Morris, & Connelly, ), disease susceptibility (Dong, Huang, Gutin, Dong, & Zhu, ), and mental disorders (Dammann et al., ; Melas et al., ; Na et al., ; Wang, Feng, et al., ); all factors that can lead to compromised life courses. While more research is needed to clarify the role of epigenetics in phenotypic expression in these areas, epigenetic intergenerational transmission could potentially be a biological component of the reproduction of poverty across generations…”
Section: Introductionmentioning
confidence: 99%
“…In this review, we describe a new hypothesized factor in this intergenerational transmission process: epigenetics – molecular processes that change the expression of genes independent of changing DNA sequence. Epigenetic marks have been observed in genes thought to impact stress response (Edelman et al., ; de Rooij et al., ), emotion regulation (Puglia, Lillard, Morris, & Connelly, ), disease susceptibility (Dong, Huang, Gutin, Dong, & Zhu, ), and mental disorders (Dammann et al., ; Melas et al., ; Na et al., ; Wang, Feng, et al., ); all factors that can lead to compromised life courses. While more research is needed to clarify the role of epigenetics in phenotypic expression in these areas, epigenetic intergenerational transmission could potentially be a biological component of the reproduction of poverty across generations…”
Section: Introductionmentioning
confidence: 99%
“…In many psychological disorders, including depression and schizophrenia, a large cohort of patients, but not all ( 46 , 47 ), display consistent biological findings ( 48 , 49 ), namely an increase in inflammation and hyperactivity of the HPA, which drives hypercortisolemia, with consequences for the GRα pool in peripheral tissues ( 50 ). Whilst it must be noted that vast heterogeneity in GRα expression exists in patients with psychological conditions ( 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ), the current review focuses on conditions/disorders which have been explicitly linked to reductions in the GRα pool ( Table 1 ). Specifically, a number of studies have demonstrated a reduction in the GRα mRNA pool in patients suffering from major depression (MD) ( 52 , 53 , 58 ), schizophrenia ( 58 ), bipolar disorder ( 58 ) and post-traumatic stress disorder ( 54 , 56 , 57 , 59 ) in various tissues of the brain (e.g.…”
Section: Reductions In the Grα Pool And Implications For Acquired Gc mentioning
confidence: 99%
“…the hippocampus and prefrontal cortex) as well as in peripheral blood mononuclear cells ( 52 , 53 , 58 ). Furthermore, in patients suffering from generalized anxiety disorder, a negative correlation was made between circulating GC concentrations and the GRα mRNA pool, which was subsequently shown to result in diminished GC sensitivity ( 55 ).…”
Section: Reductions In the Grα Pool And Implications For Acquired Gc mentioning
confidence: 99%
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