Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure

Scorza, Pamela; Duarte, Cristiane S.; Hipwell, Alison E.; Posner, Jonathan; Ortin, Ana; Canino, Glorisa; Monk, Catherine

doi:10.1111/jcpp.12877

Cited by 94 publications

(67 citation statements)

References 115 publications

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“…The risks for certain psychopathologies may commence in the previous generation. The mechanisms underlying this intergenerational transmission are thought to be epigenetic in nature, potentially affecting the germ line, with far-reaching research, clinical, and societal implications, yet more remains to be understood (Scorza et al 2018).…”

Section: Summary Pointsmentioning

confidence: 99%

Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways

Monk

Lugo‐Candelas

Trumpff

2019

Annu. Rev. Clin. Psychol.

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259

188

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The developmental origins of health and disease hypothesis applied to neurodevelopmental outcomes asserts that the fetal origins of future development are relevant to mental health. There is a third pathway for the familial inheritance of risk for psychiatric illness beyond shared genes and the quality of parental care: the impact of pregnant women's distress—defined broadly to include perceived stress, life events, depression, and anxiety—on fetal and infant brain–behavior development. We discuss epidemiological and observational clinical data demonstrating that maternal distress is associated with children's increased risk for psychopathology: For example, high maternal anxiety is associated with a twofold increase in the risk of probable mental disorder in children. We review several biological systems hypothesized to be mechanisms by which maternal distress affects fetal and child brain and behavior development, as well as the clinical implications of studies of the developmental origins of health and disease that focus on maternal distress. Development and parenting begin before birth.

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Section: Summary Pointsmentioning

confidence: 99%

Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways

Monk

Lugo‐Candelas

Trumpff

2019

Annu. Rev. Clin. Psychol.

Self Cite

259

188

View full text Add to dashboard Cite

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“…In addition, individual differences in methylation levels may also be partially explained by genetic differences ( van Dongen et al, 2016 , 2018 ). Animal studies, and to a much more limited extent human studies, have shown that early adversity, including socioeconomic disadvantage and maternal care, affects gene expression and neural function, thereby contributing to intergenerational transmission (for reviews see Meaney, 2010 ; Scorza et al, 2019 ). These studies show how environmental factors, including parent–offspring interactions and social-economic disadvantage, affect epigenetic mechanisms as well as own (parenting) behavior For example, mothers’ experience of early interpersonal violence and maltreatment was found to be related to methylation of the promoter region of the glucocorticoid receptor gene NR3C1, which in turn related to neural response to interactions with their children ( Schechter et al, 2015 ).…”

Section: Epigenetic Processesmentioning

confidence: 99%

Intergenerational transmission: Theoretical and methodological issues and an introduction to four Dutch cohorts

Branje

Geeraerts

Zeeuw

et al. 2020

Developmental Cognitive Neuroscience

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Behaviors, traits and characteristics are transmitted from parents to offspring because of complex genetic and non-genetic processes. We review genetic and non-genetic mechanisms of intergenerational transmission of psychopathology and parenting and focus on recent methodological advances in disentangling genetic and non-genetic factors. In light of this review, we propose that future studies on intergenerational transmission should aim to disentangle genetic and non-genetic transmission, take a long-term longitudinal perspective, and focus on paternal and maternal intergenerational transmission. We present four large longitudinal cohort studies within the Consortium on Individual Development, which together address many of these methodological challenges. These four cohort studies aim to examine the extent to which genetic and non-genetic transmission from the parental generation shapes parenting behavior and psychopathology in the next generation, as well as the extent to which self-regulation and social competence mediate this transmission. Conjointly, these four cohorts provide a comprehensive approach to the study of intergenerational transmission.

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“…A wealth of animal research has demonstrated that stress-induced increases in corticosterone, a glucocorticoid, is tied to the dysregulation of offspring neurobiological systems governing stress responsivity (e.g., the hypothalamic–pituitary–adrenal axis; Glover, O’Connor, & O’Donnell, 2010) and reward-sensitivity (e.g., the mesolimbic dopamine system function; Gatzke-Kopp, 2011), both of which have been implicated as vulnerability factors for psychopathology. Several additional mechanisms (e.g., effects on women’s immune functioning, women’s health behaviors, epigenetics, and the quality of the postnatal environment) have been proposed and are discussed in greater detail elsewhere (e.g., Beijers et al, 2014; Gatzke-Kopp, 2011; Schlotz & Phillips, 2009; Scorza et al, 2018; Van den Bergh, Mulder, Mennes, & Glover, 2005). …”

Section: Emotion Dysregulation and Developmental Psychopathologymentioning

confidence: 99%

Intergenerational transmission of emotion dysregulation: Part I. Psychopathology, self-injury, and parasympathetic responsivity among pregnant women

et al. 2019

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The World Health Organization recently reported that maternal mental health is a major public health concern. As many as one in four women suffer from psychiatric disorders at some point during pregnancy or the first postpartum year. Furthermore, self-injurious thoughts and behaviors (SITBs) represent one of the leading causes of death among women during this time. Thus, efforts to identify women at risk for serious forms of psychopathology and especially for SITBs are of utmost importance. Despite this urgency, current single-diagnostic approaches fail to recognize a significant subset of women who are vulnerable to perinatal stress and distress. The current study was among the first to investigate emotion dysregulation—a multilevel, transdiagnostic risk factor for psychopathology—and its associations with stress, distress, and SITBs in a sample of pregnant women (26–40 weeks gestation) recruited to reflect a range of emotion dysregulation. Both self-reported emotion dysregulation and respiratory sinus arrhythmia, a biomarker of emotion dysregulation, demonstrated expected associations with measures of mental health, including depression, anxiety, borderline personality pathology, and SITBs. In addition, self-reported emotion dysregulation was associated with blunted respiratory sinus arrhythmia responsivity to an ecologically valid infant cry task. Findings add to the literature considering transdiagnostic risk during pregnancy using a multiple-levels-of-analysis approach.

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Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure

Cited by 94 publications

References 115 publications

Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways

Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways

Intergenerational transmission: Theoretical and methodological issues and an introduction to four Dutch cohorts

Intergenerational transmission of emotion dysregulation: Part I. Psychopathology, self-injury, and parasympathetic responsivity among pregnant women

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