Increased morbidity in acute viral hepatitis with glucose-6-phosphate dehydrogenase deficiency

Jain, Ajay; Sircar, Shohini; Jain, Mayank; Adkar, Sagar; Waghmare, Chandrashekhar; Chahwala, Fatema

doi:10.1007/s12664-012-0226-9

Cited by 12 publications

(11 citation statements)

References 5 publications

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“…There are various case reports and case series from Southern Asia, where HEV GT1 is circulating, describing hemolytic anemia in patients with acute hepatitis E and G6PD-deficiency. Patients presented with fever, chills, leucocytosis, hyperbilirubinemia and impaired renal function [64][65][66][67][68]. Sometimes the decreased renal function requires dialysis, and rarely this disease took a fatal course due to cerebral bleeding, sepsis or liver failure [69,70].…”

Section: Hemolytic Anemiamentioning

confidence: 99%

Hepatitis E virus: Infection beyond the liver?

Pischke

Hartl

Pas

et al. 2017

Journal of Hepatology

202

182

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Section: Hemolytic Anemiamentioning

confidence: 99%

Hepatitis E virus: Infection beyond the liver?

Pischke

Hartl

Pas

et al. 2017

Journal of Hepatology

202

182

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“…Nevertheless, the number of published cases is rather small, and the causative relationship between HEV infection and anaemia is difficult to establish. Several cases of haemolytic anaemia, caused by glucose‐6‐phosphate dehydrogenase deficiency during HEV1 infection, have been published . A few cases of autoimmune haemolytic anaemia have been also reported in HEV‐infected patients .…”

Section: Hepatitis E Virus and Haematological Disordersmentioning

confidence: 99%

Extrahepatic manifestations of hepatitis E virus

Kamar

Marion

Abravanel

et al. 2016

Liver International

108

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Hepatitis E virus can cause acute, fulminant and chronic hepatitis and has been associated with a range of extrahepatic manifestations. Guillain-Barré syndrome, neuralgic amyotrophy and encephalitis are the main neurological manifestations associated with acute and chronic hepatitis E virus infection. Renal injuries have been also reported, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranous glomerulonephritis. Acute pancreatitis, haematological disorders and other autoimmune extrahepatic manifestations of hepatitis E virus, such as myocarditis and thyroiditis, have been also reported. In this comprehensive article, we review all published reports describing hepatitis E virus-associated extrahepatic manifestations.

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“…For example, Au et al and Gotsman et al both reported more severe clinical presentations of patients with Hepatitis E virus (HEV) and Hepatitis A virus (HAV), respectively [17, 18]. Similarly, Jain et al reported significantly higher levels of indirect bilirubin and longer hospital stay in patients with G6PD deficiency with acute viral hepatitis (HAV or HEV) compared to those that did not have G6PD deficiency [22]. While these cases represent increased severity of disease presentation, a mechanism of increased infection risk is not known.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors

et al. 2019

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Objective Deficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. To understand the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in West African blood donors. Results We evaluated the G6PD status and infectious disease screening tests of 1001 adult male Cameroonian blood donors (mean age 31.7 ± 9.8 years). The prevalence of G6PD deficiency was 7.9%. There was no difference in levels of hemoglobin or ABO subtype between those who were G6PD-normal compared to those that were deficient. Interestingly, G6PD-normal vs. deficient blood donors were less likely to have screened positive for hepatitis C virus (p = 0.02) and rapid plasma reagin (indicative of syphilis, p = 0.03). There was no significant difference in hepatitis B sAg, HIV-1, or HIV-2 reactivity between those with vs. without G6PD sufficiency. These data suggest that G6PD deficiency is common among West African male blood donors and may be associated with specific infectious disease exposure.

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Increased morbidity in acute viral hepatitis with glucose-6-phosphate dehydrogenase deficiency

Cited by 12 publications

References 5 publications

Hepatitis E virus: Infection beyond the liver?

Hepatitis E virus: Infection beyond the liver?

Extrahepatic manifestations of hepatitis E virus

Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors

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