Increased Nitrosative Stress and Oxidative DNA Damage in Patients with Carbon Monoxide Poisoning

Ertosun, Fatma Midik; Zengin, Suat; Can, Basri; Ulusal, Hasan; Yucel, Arzu; Taysı, Seyithan

doi:10.20455/ros.2020.823

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“…ONOOˉ is a powerful initiator of DNA single strand breakage, a mandatory stimulus for activation of PARS. PARS activation triggered by DNA singlestrand breakage occurs after exposure to various environmental stimuli and oxidants, especially hydroxyl radical and ONOOˉ (Szabo, 1998;Crocker et al, 2005;Ertosun et al, 2020).…”

Section: Araştırma Makalesimentioning

confidence: 99%

Civa Klorür Uygulanan Gökkuşağı Alabalıkları (Oncorhynchus Mykiss)’ nın Solungaç Dokusunda Nitrozatif ve Oksidatif Stresin Rolü

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et al. 2021

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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The aim of the study was to determine the toxic effect and the dynamics of oxidative stress caused by mercury chloride (HgCl2) in rainbow trout (Oncorhynchus mykiss) weighing 59.43±7.21 g.For this purpose, a total of 40 fish in 4 groups, 10 fish in each group (n=10), were exposed to 25% and 50% (137.75 μg L and 275 μg L) of the LD50 for 2 and 7 days. To determine the oxidative/nitrosative stress, Peroxynitrite (ONOOˉ mmol L), Total Oxidant Level (TOS mmol H2O2 Eq L), Total Antioxidant Level (TAS mmol Trolox Eq L), OSI (TOS/TASx10) and Malondialdehyde (MDA) level were determined. While the difference between the groups in terms of TAS, OSI and MDA levels in gill tissues was statistically significant (P<0.05), this difference was statistically insignificant (P>0.05) in terms of ONOOˉ and TOS values. As a result, HgCl2 was found to cause stress and toxic to fish as it increases the levels of ONOOˉ, OSI and MDA, which are indicators of stress in gill tissue.

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Section: Araştırma Makalesimentioning

confidence: 99%