Increased Number of BrdU-Labeled Neurons in the Rostral Migratory Stream of the Estrous Prairie Vole

Smith, Matthew; Pencea, Viorica; Wang, Zouxin; Luskin, Marla B.; Insel, Thomas R.

doi:10.1006/hbeh.2000.1630

Cited by 115 publications

(110 citation statements)

References 51 publications

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“…In line with prior research indicating that social factors, such as mating experience and opposite-sex chemosensory cues affect olfactory neurogenesis in adulthood (Smith et al, 2001;Baudoin et al, 2005;Mak et al, 2007;Larsen et al, 2008;Oboti et al, 2009;Corona et al, 2011), DCX expression in layer II of the PCx was highest in subordinates that were removed from their natal colonies and paired with an unfamiliar, opposite-sex conspecific. This is the first study to date to examine the relative contributions of mating experience and opposite-sex social/chemosensory stimulation to neurogenesis in the PCx; our results suggest that neurogenesis in this region is predominantly regulated by chemosensory exposure.…”

supporting

confidence: 86%

“…This possibility is supported by reports of adrenal estradiol synthesis in female naked mole-rats, and comparable concentrations of plasma estradiol among intact breeders, GDX breeders, and subordinates (Zhou et al, 2013). While it may be that estrogen mediates socially induced changes in SVZ-derived neurogenesis (Smith et al, 2001), it is also possible that extra-gonadal hormones such as prolactin regulate neurogenesis in the PCx and BLA (Mak et al, 2007). Future work will clarify whether our failure to detect an influence of gonadal factors on adult neurogenesis reflects extra-gonadal sources of regulatory hormones or hormonal insensitivity.…”

Section: Adult Neurogenesis and Gonadal Factorsmentioning

confidence: 69%

“…Estradiol also affects olfactory neurogenesis, though its influence may be modulated by social factors or other gonadal hormones, such as progesterone. Smith et al (2001) observed an increase in SVZ and OB proliferation in oestrus prairie voles exposed to a male behind a mesh fence. In line with the presence of estrogen receptors in the SVZ (Fowler et al, 2005), this socially-induced surge in proliferation was not observed in ovariectomized females, and was rescued by estradiol treatment.…”

Section: Gonadal Control Of Adult Neurogenesismentioning

confidence: 85%

“…One line of research highlights how distinct aspects of social life (E.g., sexual encounters, gestation, parenthood, and chemosensory cues conveying the sex, status and health of conspecifics) regulate the birth, fate, and integration of adult-born neurons. For example, mating encounters or exposure to opposite-sex chemosensory cues up-regulate cell proliferation in the rodent DG and SVZ (Smith et al, 2001;Larsen et al, 2008;, as well as the survival and differentiation of newborn neurons in the DG and olfactory bulb (OB) (Baudoin et al, 2005;Mak et al, 2007;Larsen et al, 2008;Oboti et al, 2009;Corona et al, 2011).…”

Section: Social Control Of Adult Neurogenesismentioning

confidence: 99%

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Social regulation of adult neurogenesis in a eusocial mammal

et al. 2014

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The present study examined social status and adult neurogenesis in the naked mole rat. These animals live in large colonies with a strict reproductive dominance hierarchy; one female and 1-3 males breed, while other members are subordinate and reproductively suppressed. We examined whether social status affects doublecortin (DCX; a marker for immature neurons) immunoreactivity in the dentate gyrus, piriform cortex (PCx), and basolateral amygdala (BLA) by comparing breeders to subordinates. We also examined subordinates removed from their colony and paired with opposite-or same-sex conspecifics for 6 months. Breeders had reduced DCX immunoreactivity in all areas, with BLA effects confined to females. Effects of housing condition were region-specific, with higher PCx DCX immunoreactivity observed in oppositethan same-sex paired subordinates regardless of gonadal status. The opposite pattern was observed in the BLA. Future work will clarify whether findings are attributable to status differences in stress, behavioural plasticity, or life stage.iii

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supporting

confidence: 86%

Section: Adult Neurogenesis and Gonadal Factorsmentioning

confidence: 69%

Section: Gonadal Control Of Adult Neurogenesismentioning

confidence: 85%

Section: Social Control Of Adult Neurogenesismentioning

confidence: 99%

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Social regulation of adult neurogenesis in a eusocial mammal

et al. 2014

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“…Gonadal hormones have been indicated as important intrinsic regulative factors of adult neurogenesis (Galea, 2008. The vast majority of the studies which have investigated the role of these hormones on adult neurogenesis has been performed in the DG of hippocampus (Galea, 2008, whereas only a few of them have addressed this issue in the SVZ neurogenic niche (Smith et al, 2001, Hoyk et al, 2006, Brock et al, 2010, Veyrac and Bakker, 2011, Tatar et al, 2013.…”

Section: Introductionmentioning

confidence: 99%

Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats

et al. 2015

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Steroid hormones are important players to regulate adult neurogenesis in the dentate gyrus of hippocampus, but their involvement in the regulation of the same phenomenon in the subventricular zone (SVZ) of the lateral ventricles is not completely understood. Here, in male rats, we tested the existence of activational effects of Testosterone (T) on cell proliferation in the adult SVZ. To this aim, three groups of male rats: castrated, castrated and treated with T, and controls were treated with BrdU and killed after 24 hours. The density of BrdU labeled cells was significantly lower in castrated animals in comparison to the other two groups, thus supporting a direct correlation between SVZ proliferation and levels of circulating T. To clarify whether this effect is purely androgen-dependent, or mediated by the T metabolites, estradiol (E 2 ) and dihydrotestosterone (DHT), we evaluated SVZ proliferation in castrated males treated with E 2 , DHT and E 2 +DHT, in comparison to T-and vehicle-treated animals, and sham-operated controls. The stereological analysis demonstrated that E 2 and T, but not DHT, increase proliferation in the SVZ of adult male rats. Quantitative evaluation of cells expressing the endogenous marker of cell proliferation PHH3, or the marker of highly dividing SVZ progenitors Mash1, indicated the effect of T/E 2 is mostly restricted to SVZ proliferating progenitors. The same experimental protocol was repeated on ovariectomized female rats treated with E 2 or T. In this case, no statistically significant difference was found among groups. Overall, our results clearly show that the gonadal hormones T and E 2 represent important mediators of cell proliferation in the adult SVZ. Moreover, we show that such effect is restricted to males, supporting adult neurogenesis in rats is a process differentially modulated in the two sexes.

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Stem Cells in the Adult Brain: Their Identification and Role in Neurogenesis

Álvarez-Buylla

Jackson

2006

Encyclopedia of Molecular Cell Biology and Molecular Medicine

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Increased Number of BrdU-Labeled Neurons in the Rostral Migratory Stream of the Estrous Prairie Vole

Cited by 115 publications

References 51 publications

Social regulation of adult neurogenesis in a eusocial mammal

Social regulation of adult neurogenesis in a eusocial mammal

Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats

Stem Cells in the Adult Brain: Their Identification and Role in Neurogenesis

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