Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease

Chen, Chiung‐Mei; Liu, Junliang; Wu, Yih‐Ru; Chen, Yi‐Chun; Cheng, Huey‐Shinn; Cheng, Mei‐Ling; Chiu, Daniel T.

doi:10.1016/j.nbd.2008.11.011

Cited by 116 publications

(80 citation statements)

References 53 publications

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“…Moreover, mitochondrial dysfunctions in aging and neurodegenerative disorders such as PD can be detected also in peripheral somatic cells [64][65][66]. Whether the pre-existing perturbation of mitochondrial functionality can be corrected upon iPSC generation is, thus, an essential question that needs to be addressed.…”

Section: Implications For the Use Of Human Ips Cells For In Vitro Modmentioning

confidence: 99%

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

et al. 2010

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The ability of stem cells to propagate indefinitely is believed to occur via the fine modulation of pathways commonly involved in cellular senescence, including the telomerase, the p53, and the mitochondrial/oxidative stress pathways. Induced pluripotent stem cells (iPSCs) are a novel stem cell population obtained from somatic cells through forced expression of a set of genes normally expressed in embryonic stem cells (ESCs). These reprogrammed cells acquire self-renewal properties and appear almost undistinguishable from ESCs in terms of morphology, gene expression, and differentiation potential. Accordingly, iPSCs exhibit alterations of the senescence-related telomerase and p53 signaling pathways. However, although treatments with antioxidants have been recently shown to enhance cellular reprogramming, detailed information regarding the state of the mitochondrial/oxidative stress pathway in iPSCs is still lacking. Mitochondria undergo specific changes during organismal development and aging. Thus, addressing whether somatic mitochondria within iPSCs acquire ESC-like features or retain the phenotype of the parental cell is an unanswered but relevant question. Herein, we demonstrate that somatic mitochondria within human iPSCs revert to an immature ESC-like state with respect to organelle morphology and distribution, expression of nuclear factors involved in mitochondrial biogenesis, content of mitochondrial DNA, intracellular ATP level, oxidative damage, and lactate generation. Upon differentiation, mitochondria within iPSCs and ESCs exhibited analogous maturation and anaerobic-to-aerobic metabolic modifications. Overall, the data highlight that human iPSCs and ESCs, although not identical, share similar mitochondrial properties and suggest that cellular reprogramming can modulate the mitochondrial/oxidative stress pathway, thus inducing a rejuvenated state capable of escaping cellular senescence.

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Section: Implications For the Use Of Human Ips Cells For In Vitro Modmentioning

confidence: 99%

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

et al. 2010

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“…Their results indicated that in plasma samples, only the 8-OHdG/2-dG ratio but not the 8-OHdG level was significantly higher in PD compared to healthy controls, suggesting that the ratio of 8-OHdG/2-dG might be a reliable diagnostic tool [15]. Another study in blood demonstrated the leucocyte 8-OHdG levels were continuously increased with advanced PD Hoehn and Yahr stages [16]. Hallucinations was reportedly occur in 50% of patients with PD [39] and have a persistent and progressive nature, and Hirayamaa and colleagues observed that the significant correlation between urinary 8-OHdG levels and hallucinations suggests that hallucinations are likely to have unique but unidentified mechanisms that lead to excessive production of 8-OHdG [17].…”

Section: ↑[14]mentioning

confidence: 99%

Recent advances in biomarkers for Parkinson’s disease focusing on biochemicals, omics and neuroimaging

Ren¹,

Sun²,

Zhao³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:Parkinson's disease (PD) is one of the most common neurodegenerative disorders, involving progressive loss of the nigro-striatal dopaminergic neurons. Cardinal symptoms including tremors, muscle rigidity, drooping posture, drooping, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic neurons have already been destroyed. Hence, reliable biomarkers are needed for early and accurate diagnosis to measure disease progression and response to therapy. We review the current status of protein and small molecule biomarkers involved in oxidative stress, protein aggregation and inflammation etc. which are present in cerebrospinal fluid, human blood, urine or saliva. In recent years, advances in genomics, proteomics, metabolomics, and functional brain imaging techniques have led to new insights into the pathoetiology of PD. Further studies in the novel discovery of PD biomarkers will provide avenues to treat PD patients more effectively with few or no side effects.

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“…Thus the findings showed that PD patients had lower levels of plasma GSH compared to healthy people at rest and peak exercise. 35 A study was conducted by Chen et al, 36 to establish whether increased oxidative damage in peripheral blood correlates with severity of PD. Basing their research on the findings that show neuronal dysfunction due to increased oxidative stress in PD patents, the researchers sought to investigate whether the pathological changes that occur in the brain of PD patients are also present in peripheral tissues.…”

Section: Glutathione Deficit and Parkinson's Diseasementioning

confidence: 99%

Nutritional Supplementation, Diet, and Genetics and Their Impact on Parkinson’s Disease (PD), a Review of Studies

Petrosino

Matende

2014

JNHFE

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Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease

Cited by 116 publications

References 53 publications

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

Recent advances in biomarkers for Parkinson’s disease focusing on biochemicals, omics and neuroimaging

Nutritional Supplementation, Diet, and Genetics and Their Impact on Parkinson’s Disease (PD), a Review of Studies

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